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Literature summary for 2.7.11.15 extracted from

  • Petrofski, J.A.; Koch, W.J.
    The beta-adrenergic receptor kinase in heart failure (2003), J. Mol. Cell. Cardiol., 35, 1167-1174.
    View publication on PubMed

Application

Application Comment Organism
medicine heart failure: therapeutic strategy by manipulating beta-AR signaling, specifically through the inhibition of beta-ARK 1, elevated levels of beta-ARK 1 are an early ubiquitous consequence of myocardial injury Mus musculus
medicine heart failure: therapeutic strategy by manipulating beta-AR signaling, specifically through the inhibition of beta-ARK 1, elevated levels of beta-ARK 1 are an early ubiquitous consequence of myocardial injury Homo sapiens
medicine effectiveness of in vivo applications of beta-ARK 1-targeted gene therapy at ameliorating heart failure, beta-ARK 1 upregulation often precedes the development of measurable heart failure and may represent an indicator for cardiac injury and potential therapeutic intervention prior to clinical dysfunction Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
studies with beta-ARK 1 knockout mice Mus musculus
studies with transgenic mice overexpressing beta-ARK 1 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + beta-adrenergic receptor Mus musculus role of beta-ARK 1 in heart failure, myocardial development and function ADP + phospho-beta-adrenergic receptor
-
?
ATP + beta-adrenergic receptor Mus musculus involved in homologous desensitization of beta-adrenergic receptor ADP + phospho-beta-adrenergic receptor
-
?
ATP + beta-adrenergic receptor Homo sapiens involved in homologous desensitization of beta-adrenergic receptor ADP + phospho-beta-adrenergic receptor
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
major isoform beta-ARK 1
-
Mus musculus
-
beta-ARK 1
-
Mus musculus
-
transgenic mouse
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Homo sapiens
-
heart beta-ARK 1 is the predominant myocardial GRK Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + beta-adrenergic receptor specifically phosphorylates the agonist-occupied form of the receptor Mus musculus ADP + phospho-beta-adrenergic receptor
-
?
ATP + beta-adrenergic receptor specifically phosphorylates the agonist-occupied form of the receptor Homo sapiens ADP + phospho-beta-adrenergic receptor
-
?
ATP + beta-adrenergic receptor role of beta-ARK 1 in heart failure, myocardial development and function Mus musculus ADP + phospho-beta-adrenergic receptor
-
?
ATP + beta-adrenergic receptor involved in homologous desensitization of beta-adrenergic receptor Mus musculus ADP + phospho-beta-adrenergic receptor
-
?
ATP + beta-adrenergic receptor involved in homologous desensitization of beta-adrenergic receptor Homo sapiens ADP + phospho-beta-adrenergic receptor
-
?
additional information domain structure Mus musculus ?
-
?
additional information domain structure Homo sapiens ?
-
?

Cofactor

Cofactor Comment Organism Structure
ATP
-
Mus musculus
ATP
-
Homo sapiens