Application | Comment | Organism |
---|---|---|
medicine | heart failure: therapeutic strategy by manipulating beta-AR signaling, specifically through the inhibition of beta-ARK 1, elevated levels of beta-ARK 1 are an early ubiquitous consequence of myocardial injury | Mus musculus |
medicine | heart failure: therapeutic strategy by manipulating beta-AR signaling, specifically through the inhibition of beta-ARK 1, elevated levels of beta-ARK 1 are an early ubiquitous consequence of myocardial injury | Homo sapiens |
medicine | effectiveness of in vivo applications of beta-ARK 1-targeted gene therapy at ameliorating heart failure, beta-ARK 1 upregulation often precedes the development of measurable heart failure and may represent an indicator for cardiac injury and potential therapeutic intervention prior to clinical dysfunction | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
studies with beta-ARK 1 knockout mice | Mus musculus |
studies with transgenic mice overexpressing beta-ARK 1 | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + beta-adrenergic receptor | Mus musculus | role of beta-ARK 1 in heart failure, myocardial development and function | ADP + phospho-beta-adrenergic receptor | - |
? | |
ATP + beta-adrenergic receptor | Mus musculus | involved in homologous desensitization of beta-adrenergic receptor | ADP + phospho-beta-adrenergic receptor | - |
? | |
ATP + beta-adrenergic receptor | Homo sapiens | involved in homologous desensitization of beta-adrenergic receptor | ADP + phospho-beta-adrenergic receptor | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
major isoform beta-ARK 1 | - |
Mus musculus | - |
beta-ARK 1 | - |
Mus musculus | - |
transgenic mouse | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Homo sapiens | - |
heart | beta-ARK 1 is the predominant myocardial GRK | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + beta-adrenergic receptor | specifically phosphorylates the agonist-occupied form of the receptor | Mus musculus | ADP + phospho-beta-adrenergic receptor | - |
? | |
ATP + beta-adrenergic receptor | specifically phosphorylates the agonist-occupied form of the receptor | Homo sapiens | ADP + phospho-beta-adrenergic receptor | - |
? | |
ATP + beta-adrenergic receptor | role of beta-ARK 1 in heart failure, myocardial development and function | Mus musculus | ADP + phospho-beta-adrenergic receptor | - |
? | |
ATP + beta-adrenergic receptor | involved in homologous desensitization of beta-adrenergic receptor | Mus musculus | ADP + phospho-beta-adrenergic receptor | - |
? | |
ATP + beta-adrenergic receptor | involved in homologous desensitization of beta-adrenergic receptor | Homo sapiens | ADP + phospho-beta-adrenergic receptor | - |
? | |
additional information | domain structure | Mus musculus | ? | - |
? | |
additional information | domain structure | Homo sapiens | ? | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus | |
ATP | - |
Homo sapiens |