Reference on EC 2.7.1.227 - inositol phosphorylceramide synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Zhong, W.; Jeffries, M.W.; Georgopapadakou, N.H.
Inhibition of inositol phosphorylceramide synthase by aureobasidin A in Candida and Aspergillus species
Antimicrob. Agents Chemother.
44
651-653
2000
Aspergillus flavus, Candida albicans, [Candida] glabrata, Candida tropicalis, [Candida] glabrata ATCC 90030, Candida tropicalis ATCC 750, Aspergillus flavus ATCC 9643, Candida albicans ATCC 90028
Aeed, P.A.; Young, C.L.; Nagiec, M.M.; Elhammer, A.P.
Inhibition of inositol phosphorylceramide synthase by the cyclic peptide aureobasidin A
Antimicrob. Agents Chemother.
53
496-504
2009
Candida albicans (O13332), Candida albicans, Saccharomyces cerevisiae (P36107), Saccharomyces cerevisiae, Candida albicans ATCC MYA-2876 (O13332)
Bromley, P.; Li, Y.; Murphy, S.; Sumner, C.; Lynch, D.
Complex sphingolipid synthesis in plants Characterization of inositolphosphorylceramide synthase activity in bean microsomes
Arch. Biochem. Biophys.
417
219-226
2003
Phaseolus vulgaris
Aeed, P.A.; Sperry, A.E.; Young, C.L.; Nagiec, M.M.; Elhammer, A.P.
Effect of membrane perturbants on the activity and phase distribution of inositol phosphorylceramide synthase; development of a novel assay
Biochemistry
43
8483-8493
2004
Candida albicans (O13332), Candida albicans, Candida albicans ATCC MYA-2876 (O13332)
Voynova, N.; Roubaty, C.; Vazquez, H.; Mallela, S.; Ejsing, C.; Conzelmann, A.
Saccharomyces cerevisiae is dependent on vesicular traffic between the Golgi apparatus and the vacuole when inositolphosphorylceramide synthase aur1 is inactivated
Eukaryot. Cell
14
1203-1216
2015
Saccharomyces cerevisiae
Mandlik, V.; Singh, S.
Molecular docking and molecular dynamics simulation study of inositol phosphorylceramide synthase - inhibitor complex in leishmaniasis Insight into the structure based drug design
F1000Res.
5
1610
2016
Leishmania major
Ohnuki, T.; Yano, T.; Ono, Y.; Kozuma, S.; Suzuki, T.; Ogawa, Y.; Takatsu, T.
Haplofungins, novel inositol phosphorylceramide synthase inhibitors, from Lauriomyces bellulus SANK 26899 I. Taxonomy, fermentation, isolation and biological activities
J. Antibiot.
62
545-549
2009
Aspergillus fumigatus, Saccharomyces cerevisiae
Nagiec, M.M.; Nagiec, E.E.; Baltisberger, J.A.; Wells, G.B.; Lester, R.L.; Dickson, R.C.
Sphingolipid synthesis as a target for antifungal drugs. Complementation of the inositol phosphorylceramide synthase defect in a mutant strain of Saccharomyces cerevisiae by the AUR1 gene
J. Biol. Chem.
272
9809-9817
1997
Saccharomyces cerevisiae (P36107), Saccharomyces cerevisiae
Denny, P.W.; Shams-Eldin, H.; Price, H.P.; Smith, D.F.; Schwarz, R.T.
The protozoan inositol phosphorylceramide synthase a novel drug target that defines a new class of sphingolipid synthase
J. Biol. Chem.
281
28200-28209
2006
Leishmania major (E9AFX2)
Wang, X.H.; Guo, X.J.; Li, H.Y.; Gou, P.
Characteristics of inositol phosphorylceramide synthase and effects of aureobasidin A on growth and pathogenicity of Botrytis cinerea
J. Gen. Appl. Microbiol.
61
108-116
2015
Botrytis cinerea
Yoo, B.; Kim, M.
Isolation of the inositol phosphoceramide synthase gene (AUR1) from stress-tolerant yeast Pichia kudriavzevii
J. Microbiol. Biotechnol.
25
1902-1907
2015
Pichia kudriavzevii (A0A099NZ49)
Levine, T.P.; Wiggins, C.A.; Munro, S.
Inositol phosphorylceramide synthase is located in the Golgi apparatus of Saccharomyces cerevisiae
Mol. Biol. Cell
11
2267-2281
2000
Saccharomyces cerevisiae (P36107), Saccharomyces cerevisiae
Sato, K.; Noda, Y.; Yoda, K.
Kei1 a novel subunit of inositolphosphorylceramide synthase, essential for its enzyme activity and Golgi localization
Mol. Biol. Cell
20
4444-4457
2009
Saccharomyces cerevisiae (Q06346 and P36107), Saccharomyces cerevisiae
Mina, J.G.; Mosely, J.A.; Ali, H.Z.; Denny, P.W.; Steel, P.G.
Exploring Leishmania major inositol phosphorylceramide synthase (LmjIPCS) insights into the ceramide binding domain
Org. Biomol. Chem.
9
1823-1830
2011
Leishmania major (E9AFX2), Leishmania major
Mina, J.G.; Okada, Y.; Wansadhipathi-Kannangara, N.K.; Pratt, S.; Shams-Eldin, H.; Schwarz, R.T.; Steel, P.G.; Fawcett, T.; Denny, P.W.
Functional analyses of differentially expressed isoforms of the Arabidopsis inositol phosphorylceramide synthase
Plant Mol. Biol.
73
399-407
2010
Arabidopsis thaliana (Q56Y01), Arabidopsis thaliana (Q9M325), Arabidopsis thaliana (Q9SH93)
Pinneh, E.; Stoppel, R.; Knight, H.; Knight, M.; Steel, P.; DennyI, P.
Expression levels of inositol phosphorylceramide synthase modulate plant responses to biotic and abiotic stress in Arabidopsis thaliana
PLoS ONE
14
e0217087
2019
Arabidopsis thaliana (Q56Y01), Arabidopsis thaliana (Q9M325), Arabidopsis thaliana (Q9SH93), Arabidopsis thaliana
Norcliffe, J.; Mina, J.; Alvarez, E.; Cantizani, J.; De Dios-Anton, F.; Colmenarejo, G.; Valle, S.; Marco, M.; Fiandor, J.; Martin, J.; Steel, P.; Denny, P.
Identifying inhibitors of the Leishmania inositol phosphorylceramide synthase with antiprotozoal activity using a yeast-based assay and ultra-high throughput screening platform
Sci. Rep.
8
8938
2018
Leishmania major (E9AFX2)
Pinneh, E.C.; Mina, J.G.; Stark, M.J.R.; Lindell, S.D.; Luemmen, P.; Knight, M.R.; Steel, P.G.; Denny, P.W.
The identification of small molecule inhibitors of the plant inositol phosphorylceramide synthase which demonstrate herbicidal activity
Sci. Rep.
9
8083
2019
Arabidopsis thaliana (Q9SH93)
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