Literature summary for 2.7.1.227 extracted from

Voynova, N.; Roubaty, C.; Vazquez, H.; Mallela, S.; Ejsing, C.; Conzelmann, A.
Saccharomyces cerevisiae is dependent on vesicular traffic between the Golgi apparatus and the vacuole when inositolphosphorylceramide synthase aur1 is inactivated (2015), Eukaryot. Cell, 14, 1203-1216 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
aureobasidin A	inhibits Aur1, activates vacuolar acidification and strongly induces the cell wall integrity pathway	Saccharomyces cerevisiae

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

General Information

General Information	Comment	Organism
physiological function	upon downregulation of Aur1 expression, the accumulation of ceramides can lead to cell death. Vesicle-mediated transport between Golgi apparatus, endosomes, and vacuole becomes crucial for survival when Aur1 is repressed, irrespective of the mode of repression. Vacuolar acidification becomes essential when cells are acutely stressed by aureobasidin A. Aureobasidin A activates vacuolar acidification and strongly induces the cell wall integrity pathway	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)