Information on EC 2.7.1.227 - inositol phosphorylceramide synthase

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IUBMB Comments
The enzyme, characterized from yeast, attaches a phosphoinositol headgroup to alpha-hydroxyphytoceramides, generating a very-long-chain inositol phospho-alpha hydroxyphytoceramide (IPC), the simplest of the three complex sphingolipids produced by yeast.
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
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a very-long-chain (2'R)-2'-hydroxyphytoceramide
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a very-long-chain inositol phospho-(2'R)-2'-hydroxyphytoceramide
Synonyms
At2g29525, At2g37940, At3g54020, AUR1, CAS74_002592, IPC synthase, IPCS, KEI1, LmjF35.4990, LMJF_35_4990, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
1-phosphatidyl-1D-myo-inositol + a very-long-chain (2'R)-2'-hydroxyphytoceramide = 1,2-diacyl-sn-glycerol + a very-long-chain inositol phospho-(2'R)-2'-hydroxyphytoceramide
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PATHWAY SOURCE
PATHWAYS
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