Literature summary for 2.7.1.227 extracted from

Wang, X.H.; Guo, X.J.; Li, H.Y.; Gou, P.
Characteristics of inositol phosphorylceramide synthase and effects of aureobasidin A on growth and pathogenicity of Botrytis cinerea (2015), J. Gen. Appl. Microbiol., 61, 108-116 .

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Protein Variants

Protein Variants	Comment	Organism
L197P/F288S/T323A	mutant displays resistance to aureobasidin A	Botrytis cinerea
additional information	a mutant strain with loss of an intron displays resistance to aureobasidin A	Botrytis cinerea

Inhibitors

Inhibitors	Comment	Organism	Structure
aureobasidin A	strongly inhibits the activity of IPC synthase in wild-type, which leads to distinct changes in cell morphology, including the delay in conidial germination, excessive branching near the tip of the germ tube and mycelium, and the inhibition of the mycelium growth. Aureobasidin A prevents the infection of wild-type in tomato fruits via reducing oxalic acid secretion and the activity of cellulase and pectinase	Botrytis cinerea

Organism

Organism	UniProt	Comment	Textmining
Botrytis cinerea	-	-	-

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Release 2023.1 (January 2023)