Literature summary for 2.7.1.227 extracted from

Pinneh, E.C.; Mina, J.G.; Stark, M.J.R.; Lindell, S.D.; Luemmen, P.; Knight, M.R.; Steel, P.G.; Denny, P.W.
The identification of small molecule inhibitors of the plant inositol phosphorylceramide synthase which demonstrate herbicidal activity (2019), Sci. Rep., 9, 8083 .

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Application

Application	Comment	Organism
analysis	expression of isoform IPCS2 in a yeast-based assay to screen for inhibitors	Arabidopsis thaliana

Inhibitors

Inhibitors	Comment	Organism	Structure
4-(2,5-dimethyl-4-[(E)-[(piperidin-1-yl)methylidene]amino]phenoxy)-2-(2,2-dimethylpropyl)benzonitrile	inhibitor shows selectivity for isoform IPCS2 over the yeast orthologue, and activity against Arabidopsis thaliana seedlings	Arabidopsis thaliana

Organism

Organism	UniProt	Comment	Textmining
Arabidopsis thaliana	Q9SH93	-	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.004	-	pH 7.4, 30°C	Arabidopsis thaliana	4-(2,5-dimethyl-4-[(E)-[(piperidin-1-yl)methylidene]amino]phenoxy)-2-(2,2-dimethylpropyl)benzonitrile

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Release 2023.1 (January 2023)