Literature summary for 2.7.1.227 extracted from

Ohnuki, T.; Yano, T.; Ono, Y.; Kozuma, S.; Suzuki, T.; Ogawa, Y.; Takatsu, T.
Haplofungins, novel inositol phosphorylceramide synthase inhibitors, from Lauriomyces bellulus SANK 26899 I. Taxonomy, fermentation, isolation and biological activities (2009), J. Antibiot., 62, 545-549 .

Search for more literature for 2.7.1.227

Inhibitors

Inhibitors	Comment	Organism	Structure
haplofungin A	isolated from Lauriomyces bellulus SANK 26899, inhibits the activity of IPC synthase with an IC50 value of 0.25 microg/ml and suppresses the growth of Candida glabrata at the MIC value of 0.5 microg/ml	Aspergillus fumigatus
haplofungin A	isolated from Lauriomyces bellulus SANK 26899, inhibits the activity of IPC synthase with an IC50 value of 0.0015 microg/ml and also suppresses the growth of Candida glabrata at the MIC value of 0.5 microg/ml	Saccharomyces cerevisiae
haplofungin E	isolated from Lauriomyces bellulus SANK 26899, inhibits the activity of IPC synthase with an IC50 value of 0.24 microg/ml and suppresses the growth of Candida glabrata at the MIC value of 0.5 microg/ml	Aspergillus fumigatus
haplofungin E	isolated from Lauriomyces bellulus SANK 26899, inhibits the activity of IPC synthase with an IC50 value of 0.0015 microg/ml and also suppresses the growth of Candida glabrata at the MIC value of 0.5 microg/ml	Saccharomyces cerevisiae

Organism

Organism	UniProt	Comment	Textmining
Aspergillus fumigatus	-	-	-
Saccharomyces cerevisiae	-	-	-

Synonyms

Synonyms	Comment	Organism
IPC synthase	-	Saccharomyces cerevisiae
IPC synthase	-	Aspergillus fumigatus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)