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Literature summary for 2.7.1.227 extracted from

  • Aeed, P.A.; Young, C.L.; Nagiec, M.M.; Elhammer, A.P.
    Inhibition of inositol phosphorylceramide synthase by the cyclic peptide aureobasidin A (2009), Antimicrob. Agents Chemother., 53, 496-504 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.227

Inhibitors

Inhibitors Comment Organism Structure
(1R)-1-cyclohexyl-5-(3,4-dimethoxyphenyl)-3-methyl-2-oxopentyl 3-hydroxy-N-methyl-N-(2-propylpentanoyl)valinate synthetic inhibitor based on aureobasdidin A structure, reversible Candida albicans
(1R)-1-cyclohexyl-5-(3,4-dimethoxyphenyl)-3-methyl-2-oxopentyl 3-hydroxy-N-methyl-N-(6-phenylhexanoyl)valinate synthetic inhibitor based on aureobasdidin A structure, reversible Candida albicans
(1R)-1-cyclohexyl-5-(3,4-dimethoxyphenyl)-3-methyl-2-oxopentyl 3-hydroxy-N-methyl-N-nonanoylvalinate synthetic inhibitor based on aureobasdidin A structure, reversible Candida albicans
aureobasidin A irreversible Candida albicans
aureobasidin A irreversible Saccharomyces cerevisiae
khafrefungin
-
 Candida albicans
khafrefungin
-
 Saccharomyces cerevisiae
rustimicin i.e. galbonolide A Candida albicans
rustimicin i.e. galbonolide A Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.003
-
 6-((N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-hexanoyl)-sphingosine pH 7.0, 23°C Saccharomyces cerevisiae
0.0033
-
 6-((N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-hexanoyl)-sphingosine pH 7.0, 23°C Candida albicans
0.13
-
 1-phosphatidyl-1D-myo-inositol pH 7.0, 23°C Candida albicans
0.555
-
 1-phosphatidyl-1D-myo-inositol pH 7.0, 23°C Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Candida albicans O13332
-
-
Candida albicans ATCC MYA-2876 O13332
-
-
Saccharomyces cerevisiae P36107
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol + 6-((N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-hexanoyl)-sphingosine
-
 Saccharomyces cerevisiae ?
-
 ?
1-phosphatidyl-1D-myo-inositol + 6-((N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-hexanoyl)-sphingosine
-
 Candida albicans ?
-
 ?
1-phosphatidyl-1D-myo-inositol + 6-((N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-hexanoyl)-sphingosine
-
 Candida albicans ATCC MYA-2876 ?
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000000183
-
 aureobasidin A pH 7.0, 23°C Candida albicans
0.00000023
-
 aureobasidin A pH 7.0, 23°C Saccharomyces cerevisiae
0.00000043
-
 khafrefungin pH 7.0, 23°C Candida albicans
0.000016
-
 rustimicin pH 7.0, 23°C Candida albicans
0.008
-
 (1R)-1-cyclohexyl-5-(3,4-dimethoxyphenyl)-3-methyl-2-oxopentyl 3-hydroxy-N-methyl-N-(2-propylpentanoyl)valinate pH 7.0, 23°C Candida albicans
0.011
-
 (1R)-1-cyclohexyl-5-(3,4-dimethoxyphenyl)-3-methyl-2-oxopentyl 3-hydroxy-N-methyl-N-(6-phenylhexanoyl)valinate pH 7.0, 23°C Candida albicans
0.012
-
 (1R)-1-cyclohexyl-5-(3,4-dimethoxyphenyl)-3-methyl-2-oxopentyl 3-hydroxy-N-methyl-N-nonanoylvalinate pH 7.0, 23°C Candida albicans

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000013
-
 pH 7.0, 23°C Saccharomyces cerevisiae rustimicin
0.000043
-
 pH 7.0, 23°C Saccharomyces cerevisiae khafrefungin