Literature summary for 2.7.1.227 extracted from

Denny, P.W.; Shams-Eldin, H.; Price, H.P.; Smith, D.F.; Schwarz, R.T.
The protozoan inositol phosphorylceramide synthase a novel drug target that defines a new class of sphingolipid synthase (2006), J. Biol. Chem., 281, 28200-28209 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in HEK 293 cell	Leishmania major

Inhibitors

Inhibitors	Comment	Organism	Structure
aureobasidin A	enzyme is inhibited at concentrations of 0.1 microM	Leishmania major

Organism

Organism	UniProt	Comment	Textmining
Leishmania major	E9AFX2	-	-

Synonyms

Synonyms	Comment	Organism
IPCS	-	Leishmania major
LmjF35.4990	-	Leishmania major

General Information

General Information	Comment	Organism
physiological function	expression in HEK 293 cells leads to the synthesis of an inositol phosphorylceramide-like species	Leishmania major

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Release 2023.1 (January 2023)