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Information on EC 2.4.2.2 - pyrimidine-nucleoside phosphorylase

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EC Tree
     2 Transferases
         2.4 Glycosyltransferases
             2.4.2 Pentosyltransferases
                2.4.2.2 pyrimidine-nucleoside phosphorylase
IUBMB Comments
Unlike EC 2.4.2.3, uridine phosphorylase, and EC 2.4.2.4, thymidine phosphorylase, this enzyme can accept both the ribonucleoside uridine and the 2'-deoxyribonucleosides 2'-deoxyuridine and thymidine . The reaction is reversible, and the enzyme does not distinguish between alpha-D-ribose 1-phosphate and 2-deoxy-alpha-D-ribose 1-phosphate in the synthetic direction.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
AmPyNP, BbPyNP, BfPyNP, BsPyNP, deoA, GsPyNP, GtPyNP, LpPyNP, PDP, phosphorylase, pyrimidine nucleoside, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2'-deoxyuridine + phosphate = uracil + 2-deoxy-alpha-D-ribose 1-phosphate
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molecular basis of catalytic chamber-assisted unfolding and cleavage of human insulin by human insulin-degrading enzyme, IDE utilizes the interaction of its exosite with the N-terminus of the insulin A chain, overview. The unique size, shape, charge distribution, and exosite of the IDE catalytic chamber contribute to its high affinity for insulin
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thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate
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(2)
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uridine + phosphate = uracil + alpha-D-ribose 1-phosphate
show the reaction diagram
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