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Information on EC 2.4.2.2 - pyrimidine-nucleoside phosphorylase

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EC Tree
     2 Transferases
         2.4 Glycosyltransferases
             2.4.2 Pentosyltransferases
                2.4.2.2 pyrimidine-nucleoside phosphorylase
IUBMB Comments
Unlike EC 2.4.2.3, uridine phosphorylase, and EC 2.4.2.4, thymidine phosphorylase, this enzyme can accept both the ribonucleosides uridine and cytidine and the 2'-deoxyribonucleosides 2'-deoxyuridine and thymidine [3,6]. The reaction is reversible, and the enzyme does not distinguish between alpha-D-ribose 1-phosphate and 2-deoxy-alpha-D-ribose 1-phosphate in the synthetic direction.
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Word Map
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
nucleoside phosphorylase, pynp, bbpynp, py-npase, ttpynp, ttha1771, pyrimidine-nucleoside phosphorylase, pyrimidine ribonucleoside phosphorylase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2'-deoxyuridine + phosphate = uracil + 2-deoxy-alpha-D-ribose 1-phosphate
show the reaction diagram
(3)
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cytidine + phosphate = cytosine + alpha-D-ribose 1-phosphate
show the reaction diagram
(2)
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thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate
show the reaction diagram
(4)
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uridine + phosphate = uracil + alpha-D-ribose 1-phosphate
show the reaction diagram
(1)
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PATHWAY SOURCE
PATHWAYS