Ligand 2'-deoxyuridine

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Basic Ligand Information

Molecular Structure
Picture of 2'-deoxyuridine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C9H12N2O5
2'-deoxyuridine
MXHRCPNRJAMMIM-SHYZEUOFSA-N
Synonyms:
1-(2-deoxy-beta-D-ribofuranosyl)uracil, 2'-deoxy-D-ribosyl-uracil, 2'deoxyuridine, 2-deoxyuridylate, D-deoxyuridine, deoxy-5-hydroxyuridine, deoxyuridine


Show all pahtways known for Show all BRENDA pathways known for 2'-deoxyuridine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2'-deoxyuridine + 2-oxoglutarate + O2 = uracil + deoxyribonolactone + succinate + CO2
show the reaction diagram
-
2'-deoxyuridine + phosphate = uracil + 2-deoxy-alpha-D-ribose 1-phosphate
show the reaction diagram
-
2'-deoxy-D-ribosyl-uracil + adenine = 2'-deoxy-D-ribosyl-adenine + uracil
show the reaction diagram
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ATP + 2'-deoxyuridine = ADP + 2'-deoxyuridine 5'-phosphate
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5'-dUMP + H2O = deoxyuridine + phosphate
show the reaction diagram
-
-
deoxycytidine + H2O = deoxyuridine + NH3
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-
-
2'-deoxycytidine + H2O = 2'-deoxyuridine + NH3
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (61 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2'-deoxyuridine + Br- + H2O2 = 5-bromo-2'-deoxyuridine + H2O
show the reaction diagram
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2'-deoxyuridine + 2-oxoglutarate + O2 = uracil + deoxyribonolactone + succinate + CO2
show the reaction diagram
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AMP + deoxyuridine = adenosine + deoxyuridine 5'-phosphate
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phenyl phosphate + deoxyuridine = dUMP + phenol
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p-nitrophenyl phosphate + 2'-deoxyuridine = ?
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2'-deoxyuridine + H2O = uracil + 2-deoxy-D-ribose
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Product in Enzyme-catalyzed Reactions (31 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2'-deoxy-uridine 5'-phosphate + trans-farnesyl diphosphate = 2'-deoxyuridine + trans-farnesyl triphosphate
show the reaction diagram
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-
2'-deoxyuridine 5'-phosphate + H2O = 2'-deoxyuridine + phosphate
show the reaction diagram
-
-
dUMP + H2O = deoxyuridine + phosphate
show the reaction diagram
-
-
5'-dUMP + H2O = deoxyuridine + phosphate
show the reaction diagram
-
-
deoxycytidine + H2O = deoxyuridine + NH3
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-
2'-deoxycytidine + H2O = 2'-deoxyuridine + NH3
show the reaction diagram
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-

Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (23 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
reaction with thymidine and 2'-deoxycytidine
-
hydrolysis of 5'-dUMP
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3D Structure of Enzyme-Ligand-Complex (PDB) (12 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (14 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
24.6
-
pH 7.6, 37°C
35
-
-
483
-
pH 6.5, 40°C

KM Value (21 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.19
-
-
1.14
-
pH 6.5, 40°C

Ki Value (5 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for 2'-deoxyuridine

ChEBI
PubChem
ChEBI
PubChem