Ligand cytidine

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Basic Ligand Information

Molecular Structure
Picture of cytidine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C9H13N3O5
cytidine
UHDGCWIWMRVCDJ-XVFCMESISA-N


Show all pahtways known for Show all BRENDA pathways known for cytidine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
cytidine + 2 O2 + H2O = 1-riburonosylcytosine + 2 H2O2
show the reaction diagram
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cytidine + ATP = CMP + ADP
show the reaction diagram
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cytidine + H2O = D-ribose + cytosine
show the reaction diagram
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cytidine + H2O = uridine + NH3
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (66 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
cytidine + O2 = 1-riburonosylcytosine + H2O
show the reaction diagram
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cytidine + 2 O2 + H2O = 1-riburonosylcytosine + 2 H2O2
show the reaction diagram
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cytidine + Br- + H2O2 = 5-bromocytidine + H2O
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Br- + H2O2 + cytidine = 5-bromocytidine + H2O
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cytidine + phosphate = cytosine + alpha-D-ribose 1-phosphate
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AMP + cytidine = adenosine + cytidine 5'-phosphate
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ATP + cytidine = ADP + CMP
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3 cytidine = ?
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cytidine + H2O = cytosine + D-ribose
show the reaction diagram
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cytidine + H2O = cytosine + D-ribose
show the reaction diagram
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cytidine + H2O = 1-beta-D-ribofuranosylpyrimidin-2(1H)-one + NH3
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cytidine + H2O = uridine + NH3
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cytidine + H2O = ?
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cytidine + H2O = uridine + NH3
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (39 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dCMP + base = dNMP + cytidine
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CpC + H2O = 5'-CMP + cytidine
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3'-CMP + H2O = cytidine + phosphate
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CDP + H2O = cytidine + diphosphate
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CpC + H2O = CMP + cytidine
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Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
2',3'-cyclic nucleotide phosphodiesterase activity
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Inhibitor in Enzyme-catalyzed Reactions (27 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
17% inhibition of fructose 6-phosphate reduction
-
0.1 mM, 10-90% inhibition
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substrate inhibition
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60 mM, 37% inhibition
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0.5 mM, 81% inhibition of activity with adenosine, 92% inhibition of activity with inosine, 91% inhibition of the activity with xanthosine, 94% inhibition of activity with guanosine
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noncompetitive
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at 6.25 mM, competitive inhibitor for uridine hydrolysis
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strong substrate inhibition above 0.5 mM
allosteric inhibition, moderate decrease in activity
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3D Structure of Enzyme-Ligand-Complex (PDB) (20 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (24 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
1.02
-
25fold reduction
280
-
pH and temperature not specified in the publication
0.064
-
pH 8.0, 22°C
1.12
-
pH 7.2, 32°C, recombinant His-tagged enzyme
4.8
-
in 50 mM Tris-HCl buffer pH 7.5 at 25°C

KM Value (86 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.28
-
-
0.9
-
pH 8.0, 37ºC
0.682
-
pH 7.2, 32°C, recombinant His-tagged enzyme

Ki Value (6 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
29.3
-
pH and temperature not specified in the publication
2
-
pH 7.5, 37°C, wild-type enzyme, versus uridine

References & Links

Links to other databases for cytidine

ChEBI
PubChem
ChEBI
PubChem