Ligand thymine

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Basic Ligand Information

Molecular Structure
Picture of thymine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H6N2O2
thymine
RWQNBRDOKXIBIV-UHFFFAOYSA-N
Synonyms:
5-methyluracil


Show all pahtways known for Show all BRENDA pathways known for thymine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
thymine + FMNH2 + O2 = (Z)-2-methylureidoacrylate peracid + FMN
show the reaction diagram
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thymine + H2O + acceptor = 5-methylbarbiturate + reduced acceptor
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thymine + NADH + H+ = 5,6-dihydrothymine + NAD+
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thymine + NADPH = dihydrothymine + NADP+
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dihydrothymine + NADP+ = thymine + NADPH + H+
show the reaction diagram
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thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate
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thymine-mismatched double-stranded DNA + H2O = thymine + double-stranded DNA with abasic site
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5-methylcytosine + H2O = thymine + NH3
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Substrate in Enzyme-catalyzed Reactions (45 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
thymine + Br- + H2O2 = 5-bromo-6-hydroxy-5,6-dihydrothymine + H2O
show the reaction diagram
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thymine + FMNH2 + O2 = (Z)-2-methylureidoacrylate peracid + FMN
show the reaction diagram
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2'-deoxyuridine + thymine = thymidine + uracil
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inosine + thymine = hypoxanthine + 5-methyluridine
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ATP + thymine + H2O = ?
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thymine + H2O = ?
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thymine = ?
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Product in Enzyme-catalyzed Reactions (173 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1-methylthymine + 2-oxoglutarate + O2 = 1-methyl-5-(hydroxymethyl)uracil + thymine + formaldehyde + succinate + CO2
show the reaction diagram
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dihydrothymine + NAD+ = thymine + NADH + H+
show the reaction diagram
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dihydrothymine + O2 = thymine + H2O2
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5'-deoxy TMP + H2O = thymine + deoxyribose 5-phosphate
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5-methyluridine + H2O = D-ribose + 5-methyluracil
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thymine-mismatched double-stranded DNA + H2O = thymine + double-stranded DNA with abasic site
show the reaction diagram
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5-methylcytosine + H2O = thymine + NH3
show the reaction diagram
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5-methylcytosine + H2O = 5-methyluracil + NH3
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive vs. dihydrouracil
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1 mM, about 90% inhibition
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IC50: 0.29 mM
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3D Structure of Enzyme-Ligand-Complex (PDB) (13 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (7 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.39
-
pH 6.0, 30°C; pH 6.0, 30°C

KM Value (22 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.035
-
-
0.087
-
pH 6.0, 30°C; pH 6.0, 30°C
0.13
-
reaction with deoxyinosine
16
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Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.003
-
-

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.29
-
IC50: 0.29 mM

References & Links

Links to other databases for thymine

ChEBI
PubChem
ChEBI
PubChem