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Literature summary for 2.4.2.2 extracted from
- Pyrimidine nucleoside phosphorylase and dihydropyrimidine dihydrogenase activities as predictive factors for the efficacy of doxifluridine together with mitomycin C as adjuvant chemotherapy in primary colorectal cancer (2007), Hepatogastroenterology, 54, 1089-1093.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pyrimidine nucleoside + phosphate | Homo sapiens | most pyrimidine nucleosides except for 4-amino-substituted species like deoxycytidine | pyrimidine base + alpha-D-ribose 1-phosphate | or alpha-D-deoxyribose 1-phosphate | r |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| colorectal cancer cell | PyNPase level quantified by sandwich ELISA using monoclonal anti-human thimidine phosphorylase antibodies 104B and 232-2, no association between PyNPase level and recurrence, disease-free survival at year 2.2 better with low PyNPase levels and high PyNPase-to-dihydropyrimidine dihydrogenase ratio | Homo sapiens | - |
| colorectum | PyNPase level quantified by sandwich ELISA using monoclonal anti-human thimidine phosphorylase antibodies 104B and 232-2 | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5'-deoxy-5-fluorouridine + phosphate | - |
Homo sapiens | 5-fluorouracil + alpha-D-deoxyribose 1-phosphate | 5-fluorouracil is a chemotherapeutic agent and inactivated by dihydropyrimidine dihydrogenase activity | ? | |
| pyrimidine nucleoside + phosphate | most pyrimidine nucleosides except for 4-amino-substituted species like deoxycytidine | Homo sapiens | pyrimidine base + alpha-D-ribose 1-phosphate | or alpha-D-deoxyribose 1-phosphate | r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| pynpase | - |
Homo sapiens |
| pyrimidine nucleoside phosphorylase | - |
Homo sapiens |
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