Ligand uridine

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Basic Ligand Information

Molecular Structure
Picture of uridine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C9H12N2O6
uridine
DRTQHJPVMGBUCF-XVFCMESISA-N
Synonyms:
1-Ribosyluracil, 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione, deazauridine, Uridine arabinoside


Show all pahtways known for Show all BRENDA pathways known for uridine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
uridine + 2 O2 + H2O = 1-riburonosyluracil + 2 H2O2
show the reaction diagram
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uridine + phosphate = uracil + alpha-D-ribose 1-phosphate
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uridine + ATP = UMP + ADP
show the reaction diagram
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uridine + H2O = D-ribose + uracil
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
uridine-mismatched double-stranded DNA + H2O = uridine + double-stranded DNA with abasic site
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cytidine + H2O = uridine + NH3
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UDP + 2 H2O = uridine + 2 phosphate
show the reaction diagram
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UMP + H2O = uridine + phosphate
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (70 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
uridine + O2 = 1-riburonosyluracil + H2O
show the reaction diagram
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uridine + 2 O2 + H2O = 1-riburonosyluracil + 2 H2O2
show the reaction diagram
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uridine + 2-oxoglutarate + O2 = ribonolactone + uracil + succinate + CO2
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uridine + phosphate = uracil + alpha-D-ribose 1-phosphate
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guanine + uridine = guanosine + uracil
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uridine + ATP = UMP + ADP
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AMP + uridine = adenosine + uridine 5'-phosphate
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ATP + uridine = ADP + UMP
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ATP + uridine = ?
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uridine + ATP = UMP + ADP
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ATP + uridine = ADP + uridine 5'-phosphate
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3 uridine = ?
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4-nitrophenyl sulfate + uridine = 4-nitrophenol + uridine 2'-sulfate
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p-nitrophenyl phosphate + uridine = ?
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uridine + H2O = D-ribose + uracil
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uridine + H2O = uracil + D-ribose
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Product in Enzyme-catalyzed Reactions (64 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2'-deoxyuridine + 2-oxoglutarate + O2 = uridine + succinate + CO2
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zebularine + H2O + O2 = uridine + H2O2
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uracil + phosphoribose diphosphate = diphosphate + uridine
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CpU + H2O = 3'-CMP + uridine
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3'-UMP + H2O = uridine + phosphate
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UMP + H2O = uridine + phosphate
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3'-UMP + H2O = uridine + phosphate
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uridine-mismatched double-stranded DNA + H2O = uridine + double-stranded DNA with abasic site
show the reaction diagram
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cytidine + H2O = uridine + NH3
show the reaction diagram
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cytidine + H2O = uridine + NH3
show the reaction diagram
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UDP + 2 H2O = uridine + 2 phosphate
show the reaction diagram
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uridine-5'-phosphoro-p-anisidine + H2O = uridine + p-anisidine + phosphate
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orotidine = uridine + CO2
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UpU + H2O = 3'-UMP + uridine
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Activator in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activation, deoxycytidine as substrate, mitochondrial isozyme
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2',3'-cyclic nucleotide phosphodiesterase activity
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Inhibitor in Enzyme-catalyzed Reactions (57 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
16% inhibition of fructose 6-phosphate reduction
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1 mM, about 85% inhibition
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above 15 mM, competitive inhibition of cleavage of 5-bromodeoxyuridine
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competitive inhibition
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noncompetitive
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weak, cytosolic isozyme I
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inhibitor of phosphatase reaction
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7.5% inhibition at 0.86 mM
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above 0.4 mM
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3D Structure of Enzyme-Ligand-Complex (PDB) (39 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (43 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.09
-
pH 7.4
1.67
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15fold reduction

KM Value (119 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.08
-
-
4.71
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38C, pH 7.5
0.86
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pH 8.0, 37C
1.7
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pH 7.0, 37C
0.8
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pH and temperature not specified in the publication

Ki Value (12 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
90
-
80C, pH 5.0
90
-
-
0.25
-
-
0.047
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-
0.013
0.05
dependent on the assay method, pH 8.5, temperature not specified in the publication

IC50 Value (3 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.05
-
pH 8.5, temperature not specified in the publication

References & Links

Links to other databases for uridine

ChEBI
PubChem
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PubChem