Reference on EC 1.14.11.2 - procollagen-proline 4-dioxygenase and Organism(s) Homo sapiens and UniProt Accession Q96KS0
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Pihlajaniemi, T.; Helaakoski, T.; Tasanen, K.; Myllylä, R.; Huhtala, M.L.; Koivu, J.; Kivirikko, K.I.
Molecular cloning of the beta-subunit of human prolyl 4-hydroxylase. This subunit and protein disulfide isomerase are products of the same gene
EMBO J.
6
643-649
1987
Homo sapiens
Kivirikko, K.I.; Myllylä, R.
The hydroxylation of prolyl and lysyl residues
Enzymol. Post- transl. Modif. Proteins (Freedman, R. B. , Hawkins, H. C. , eds. ) Academic Press, New York
1
53-104
1980
Gallus gallus, Homo sapiens, Rattus norvegicus
-
Kivirikko, K.I.; Myllylä, R.
Posttranslational enzymes in the biosynthesis of collagen: intracellular enzymes
Methods Enzymol.
82
245-304
1982
Gallus gallus, Homo sapiens, Rattus norvegicus
Guzman, N.A.; Ascari, W.Q.; Cutroneo, K.R.; Desnick, R.J.
Comparison between avian and human prolyl 4-hydroxylases: studies on the holomeric enzymes and their constituent subunits
J. Cell. Biochem.
48
172-189
1992
Gallus gallus, Homo sapiens
Kivirikko, K.I.; Myllylä, R.; Pihlajaniemi, T.
Protein hydroxylation: prolyl 4-hydroxylase, an enzyme with four cosubstrates and a multifunctional subunit
FASEB J.
3
1609-1617
1989
Gallus gallus, Homo sapiens, Mus musculus, Volvox carteri
Gunzler, V.; Brocks, D.; Henke, S.; Myllylä, R.; Geiger, R.; Kivirikko, K.I.
Syncatalytic inactivation of prolyl 4-hydroxylase by synthetic peptides containing the unphysiologic amino acid 5-oxaproline
J. Biol. Chem.
263
19498-19504
1988
Gallus gallus, Homo sapiens
Gunzler, V.; Hanauske-Abel, H.M.; Myllylä, R.; Kaska, D.D.; Hanauske, A.; Kivirikko, K.I.
Syncatalytic inactivation of prolyl 4-hydroxylase by anthracyclines
Biochem. J.
251
365-372
1988
Gallus gallus, Homo sapiens
Gunzler, V.; Hanauske-Abel, H.M.; Myllylä, R.; Mohr, J.; Kivirikko, K.I.
Time-dependent inactivation of chick-embryo prolyl 4-hydroxylase by coumalic acid. Evidence for a syncatalytic mechanism
Biochem. J.
242
163-169
1987
Gallus gallus, Homo sapiens
Kivirikko, K.I.; Myllylä, R.
Recent developments in posttranslational modification: intracellular processing
Methods Enzymol.
144
96-114
1987
Gallus gallus, Homo sapiens, Mus musculus
Kuutti, L.R.; Tuderman, L.; Kivirikko, K.I.
Human prolyl hydroxylase. Purification, partial characterization and preparation of antiserum to the enzyme
Eur. J. Biochem.
57
181-188
1975
Homo sapiens
Helaakoski, T.; Vuori, K.; Myllyla, R.; Kivirikko, K.I.; Pihlajaniemi, T.
Molecular cloning of the a-subunit of human prolyl 4-hydroxylase: the complete cDNA-derived amino acid sequence and evidence for alternative splicing of RNA transcripts
Proc. Natl. Acad. Sci. USA
86
4392-4396
1989
Homo sapiens
Lamberg, A.; Pihlajaniemi, T.; Kivirikko, K.I.
Site-directed mutagenesis of the a subunit of human prolyl 4-hydroxylase. Identification of three histidine residues critical for catalytic activity
J. Biol. Chem.
270
9926-9931
1995
Homo sapiens
Helaakoski, T.; Annunen, P.; Vuori, K.; MacNeil, I.A.; Pihlajaniemi, T.; Kivirikko, K.I.
Cloning, baculovirus expression, and characterization of a second mouse prolyl 4-hydroxylase a-subunit isoform: formation of an a2b2 tetramer with the protein disulfide-isomerase/b subunit
Proc. Natl. Acad. Sci. USA
92
4427-4431
1995
Homo sapiens, Mus musculus
Mazzorana, M.; Snellman, A.; Kivirikko, K.I.; van der Rest, M.; Pihlajaniemi, T.
Involvement of prolyl 4-hydroxylase in the assembly of trimeric minicollagen XII. Study in baculovirus expression system
J. Biol. Chem.
271
29003-29008
1996
Homo sapiens
Annunen, P.; Helaakoski, T.; Myllyharju, J.; Veijola, J.; Pihlajaniemi, T.; Kivirikko, K.I.
Cloning of the human prolyl 4-hydroxylase a subunit isoform a(II) and characterization of the type II enzyme tetramer. The a(I) and a(II) subunits do not form a mixed a(I)a(II)b2 tetramer
J. Biol. Chem.
272
17342-17348
1997
Gallus gallus, Homo sapiens (O15460), Homo sapiens
Annunen, P.; Autio-Harmainen, H.; Kivirikko, K.I.
The novel type II prolyl 4-hydroxylase is the main enzyme form in chondrocytes and capillary endothelial cells, whereas the type I enzyme predominates in most cells
J. Biol. Chem.
273
5989-5992
1998
Homo sapiens, Mus musculus
Annunen, P.; Koivunen, P.; Kivirikko, K.I.
Cloning of the a subunit of prolyl 4-hydroxylase from Drosophila and expression and characterization of the corresponding enzyme tetramer with some unique properties
J. Biol. Chem.
274
6790-6796
1999
Drosophila melanogaster, Homo sapiens
Franklin, T.J.; Morris, W.P.; Edwards, P.N.; Large, M.S.; Stephenson, R.
Inhibition of prolyl 4-hydroxylase in vitro and in vivo by members of a novel series of phenanthrolinones
Biochem. J.
353
333-338
2001
Gallus gallus, Homo sapiens, Rattus norvegicus, Rattus norvegicus Sprague-Dawley
ekkala, M.; Hieta, R.; Kursula, P.; Kivirikko, K.I.; Wierenga, R.K.; Myllyharju, J.
Crystallization of the proline-rich-peptide binding domain of human type I collagen prolyl 4-hydroxylase
Acta Crystallogr. Sect. D
59
940-942
2003
Homo sapiens
Nissi, R.; Bohling, T.; Autio-Harmainen, H.
Immunofluorescence localization of prolyl 4-hydroxylase isoenzymes and type I and II collagens in bone tumours: type I enzyme predominates in osteosarcomas and chondrosarcomas, whereas type II enzyme predominates in their benign counterparts
Acta Histochem.
106
111-121
2004
Homo sapiens, Rattus norvegicus
Tuckerman, J.R.; Zhao, Y.; Hewitson, K.S.; Tian, Y.M.; Pugh, C.W.; Ratcliffe, P.J.; Mole, D.R.
Determination and comparison of specific activity of the HIF-prolyl hydroxylases
FEBS Lett.
576
145-150
2004
Homo sapiens, Homo sapiens (Q96KS0), Homo sapiens (Q9H6Z9)
Hirsila, M.; Koivunen, P.; Gunzler, V.; Kivirikko, K.I.; Myllyharju, J.
Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor
J. Biol. Chem.
278
30772-30780
2003
Homo sapiens (Q96KS0), Homo sapiens (Q9GZT9), Homo sapiens (Q9H6Z9)
Hieta, R.; Kukkola, L.; Permi, P.; Pirilae, P.; Kivirikko, K.I.; Kilpelaeinen, I.; Myllyharju, J.
The peptide-substrate-binding domain of human collagen prolyl 4-hydroxylases: backbone assignments, secondary structure, and binding of proline-rich peptides
J. Biol. Chem.
278
34966-34974
2003
Homo sapiens
Kukkola, L.; Hieta, R.; Kivirikko, K.I.; Myllyharju, J.
Identification and characterization of a third human, rat, and mouse collagen prolyl 4-hydroxylase isoenzyme
J. Biol. Chem.
278
47685-47693
2003
Rattus norvegicus (Q6W3E9), Mus musculus (Q6W3F0), Mus musculus, Homo sapiens (Q7Z4N8), Homo sapiens
Myllyharju, J.
Prolyl 4-hydroxylases, the key enzymes of collagen biosynthesis
Matrix Biol.
22
15-24
2003
Arabidopsis thaliana, Drosophila melanogaster, Paramecium bursaria Chlorella virus-1, Homo sapiens (O15460), Homo sapiens (P13674), Caenorhabditis elegans (Q20065)
Kersteen, E.A.; Higgin, J.J.; Raines, R.T.
Production of human prolyl 4-hydroxylase in Escherichia coli
Protein Expr. Purif.
38
279-291
2004
Homo sapiens
Li, H.C.; Huang, C.C.; Chen, S.F.; Chou, M.Y.
Assembly of homotrimeric type XXI minicollagen by coexpression of prolyl 4-hydroxylase in stably transfected Drosophila melanogaster S2 cells
Biochem. Biophys. Res. Commun.
336
375-385
2005
Homo sapiens
Tian, Y.M.; Mole, D.R.; Ratcliffe, P.J.; Gleadle, J.M.
Characterization of different isoforms of the HIF prolyl hydroxylase PHD1 generated by alternative initiation
Biochem. J.
397
179-186
2006
Homo sapiens
Cervera, A.M.; Apostolova, N.; Luna-Crespo, F.; Sanjuan-Pla, A.; Garcia-Bou, R.; McCreath, K.J.
An alternatively spliced transcript of the PHD3 gene retains prolyl hydroxylase activity
Cancer Lett.
233
131-138
2006
Homo sapiens
Callapina, M.; Zhou, J.; Schnitzer, S.; Metzen, E.; Lohr, C.; Deitmer, J.W.; Bruene, B.
Nitric oxide reverses desferrioxamine- and hypoxia-evoked HIF-1alpha accumulation--implications for prolyl hydroxylase activity and iron
Exp. Cell Res.
306
274-284
2005
Homo sapiens
Chen, L.; Shen, Y.H.; Wang, X.; Wang, J.; Gan, Y.; Chen, N.; Wang, J.; LeMaire, S.A.; Coselli, J.S.; Wang, X.L.
Human prolyl-4-hydroxylase alpha(I) transcription is mediated by upstream stimulatory factors
J. Biol. Chem.
281
10849-10855
2006
Homo sapiens
Neubauer, A.; Soini, J.; Bollok, M.; Zenker, M.; Sandqvist, J.; Myllyharju, J.; Neubauer, P.
Fermentation process for tetrameric human collagen prolyl 4-hydroxylase in Escherichia coli: improvement by gene optimisation of the PDI/beta subunit and repeated addition of the inducer anhydrotetracycline
J. Biotechnol.
128
308-321
2007
Homo sapiens
Neubauer, A.; Neubauer, P.; Myllyharju, J.
High-level production of human collagen prolyl 4-hydroxylase in Escherichia coli
Matrix Biol.
24
59-68
2005
Homo sapiens
Choi, K.O.; Lee, T.; Lee, N.; Kim, J.H.; Yang, E.G.; Yoon, J.M.; Kim, J.H.; Lee, T.G.; Park, H.
Inhibition of the catalytic activity of hypoxia-inducible factor-1alpha-prolyl-hydroxylase 2 by a MYND-type zinc finger
Mol. Pharmacol.
68
1803-1809
2005
Homo sapiens
Cummins, E.P.; Berra, E.; Comerford, K.M.; Ginouves, A.; Fitzgerald, K.T.; Seeballuck, F.; Godson, C.; Nielsen, J.E.; Moynagh, P.; Pouyssegur, J.; Taylor, C.T.
Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity
Proc. Natl. Acad. Sci. USA
103
18154-18159
2006
Homo sapiens
McDonough, M.A.; Li, V.; Flashman, E.; Chowdhury, R.; Mohr, C.; Lienard, B.M.; Zondlo, J.; Oldham, N.J.; Clifton, I.J.; Lewis, J.; McNeill, L.A.; Kurzeja, R.J.; Hewitson, K.S.; Yang, E.; Jordan, S.; Syed, R.S.; Schofield, C.J.
Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)
Proc. Natl. Acad. Sci. USA
103
9814-9819
2006
Homo sapiens
Meng, L.; Huang, M.; Ye, X.; Fan, M.; Bian, Z.
Increased expression of collagen prolyl 4-hydroxylases in Chinese patients with hereditary gingival fibromatosis
Arch. Oral Biol.
52
1209-1214
2007
Homo sapiens
Villar, D.; Vara-Vega, A.; Landazuri, M.O.; Del Peso, L.
Identification of a region on hypoxia-inducible-factor prolyl 4-hydroxylases that determines their specificity for the oxygen degradation domains
Biochem. J.
408
231-240
2007
Homo sapiens (Q96KS0), Homo sapiens (Q9GZT9), Homo sapiens (Q9H6Z9)
Gorres, K.L.; Edupuganti, R.; Krow, G.R.; Raines, R.T.
Conformational preferences of substrates for human prolyl 4-hydroxylase
Biochemistry
47
9447-9455
2008
Homo sapiens
Zhang, C.; Zhang, M.; Shen, Y.H.; Burks, J.K.; Li, X.; LeMaire, S.A.; Yoshimura, K.; Aoki, H.; Matsuzaki, M.; An, F.; Engler, D.A.; Matsunami, R.K.; Coselli, J.S.; Zhang, Y.; Wang, X.L.
Role of NonO-histone interaction in TNFalpha-suppressed prolyl-4-hydroxylase alpha 1
Biochim. Biophys. Acta
1783
1517-1528
2008
Homo sapiens
Koivunen, P.; Tiainen, P.; Hyvaerinen, J.; Williams, K.E.; Sormunen, R.; Klaus, S.J.; Kivirikko, K.I.; Myllyharju, J.
An endoplasmic reticulum transmembrane prolyl 4-hydroxylase is induced by hypoxia and acts on hypoxia-inducible factor alpha
J. Biol. Chem.
282
30544-30552
2007
Homo sapiens
Gorres, K.L.; Raines, R.T.
Direct and continuous assay for prolyl 4-hydroxylase
Anal. Biochem.
386
181-185
2009
Homo sapiens
Myllyharju, J.
Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets
Ann. Med.
40
402-417
2008
Caenorhabditis elegans, Chlamydomonas reinhardtii, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus
Stein, H.; Wilensky, M.; Tsafrir, Y.; Rosenthal, M.; Amir, R.; Avraham, T.; Ofir, K.; Dgany, O.; Yayon, A.; Shoseyov, O.
Production of bioactive, post-translationally modified, heterotrimeric, human recombinant type-I collagen in transgenic tobacco
Biomacromolecules
10
2640-2645
2009
Homo sapiens
Qi, H.H.; Ongusaha, P.P.; Myllyharju, J.; Cheng, D.; Pakkanen, O.; Shi, Y.; Lee, S.W.; Peng, J.; Shi, Y.
Prolyl 4-hydroxylation regulates Argonaute 2 stability
Nature
455
421-424
2008
Homo sapiens
Gorres, K.L.; Pua, K.H.; Raines, R.T.
Stringency of the 2-His-1-Asp active-site motif in prolyl 4-hydroxylase
PLoS ONE
4
e7635
2009
Homo sapiens
Chowdhury, R.; McDonough, M.A.; Mecinovic, J.; Loenarz, C.; Flashman, E.; Hewitson, K.S.; Domene, C.; Schofield, C.J.
Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases
Structure
17
981-989
2009
Homo sapiens
Xue, J.; Li, X.; Jiao, S.; Wei, Y.; Wu, G.; Fang, J.
Prolyl hydroxylase-3 is down-regulated in colorectal cancer cells and inhibits IKKbeta independent of hydroxylase activity
Gastroenterology
138
606-615
2010
Homo sapiens
Vogel, S.; Wottawa, M.; Farhat, K.; Zieseniss, A.; Schnelle, M.; Le-Huu, S.; von Ahlen, M.; Malz, C.; Camenisch, G.; Katschinski, D.M.
Prolyl hydroxylase domain (PHD) 2 affects cell migration and F-actin formation via RhoA/rho-associated kinase-dependent cofilin phosphorylation
J. Biol. Chem.
285
33756-33763
2010
Homo sapiens
Tennant, D.A.; Gottlieb, E.
HIF prolyl hydroxylase-3 mediates alpha-ketoglutarate-induced apoptosis and tumor suppression
J. Mol. Med.
88
839-849
2010
Homo sapiens
Spinella, F.; Rosano, L.; Del Duca, M.; Di Castro, V.; Nicotra, M.R.; Natali, P.G.; Bagnato, A.
Endothelin-1 inhibits prolyl hydroxylase domain 2 to activate hypoxia-inducible factor-1alpha in melanoma cells
PLoS ONE
5
e11241
2010
Homo sapiens
Pektas, S.; Knapp, M.J.
Substrate preference of the HIF-prolyl hydroxylase-2 (PHD2) and substrate-induced conformational change
J. Inorg. Biochem.
126
55-60
2013
Homo sapiens
Yum, S.; Choi, J.; Hong, S.; Park, M.H.; Lee, J.; Ha, N.C.; Jung, Y.
Hyperoxia attenuates the inhibitory effect of nitric oxide donors on HIF prolyl-4-hydroxylase-2: Implication on discriminative effect of nitric oxide on HIF prolyl-4-hydroxylase-2 and collagen prolyl-4-hydroxylase
Biochem. Pharmacol.
82
485-490
2011
Homo sapiens
Vasta, J.D.; Higgin, J.J.; Kersteen, E.A.; Raines, R.T.
Bioavailable affinity label for collagen prolyl 4-hydroxylase
Bioorg. Med. Chem.
21
3597-3601
2013
Caenorhabditis elegans, Homo sapiens
Song, D.; Li, L.S.; Heaton-Johnson, K.J.; Arsenault, P.R.; Master, S.R.; Lee, F.S.
Prolyl hydroxylase domain protein 2 (PHD2) binds a Pro-Xaa-Leu-Glu motif, linking it to the heat shock protein 90 pathway
J. Biol. Chem.
288
9662-9674
2013
Homo sapiens
Duran, R.V.; MacKenzie, E.D.; Boulahbel, H.; Frezza, C.; Heiserich, L.; Tardito, S.; Bussolati, O.; Rocha, S.; Hall, M.N.; Gottlieb, E.
HIF-independent role of prolyl hydroxylases in the cellular response to amino acids
Oncogene
32
4549-4556
2013
Homo sapiens
Xiong, G.; Deng, L.; Zhu, J.; Rychahou, P.G.; Xu, R.
Prolyl-4-hydroxylase alpha subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition
BMC Cancer
14
1-1
2014
Homo sapiens (O15460)
Liu, X.; Huang, X.; Chen, L.; Zhang, Y.; Li, M.; Wang, L.; Ge, C.; Wang, H.; Zhang, M.
Mechanical stretch promotes matrix metalloproteinase-2 and prolyl-4-hydroxylase alpha1 production in human aortic smooth muscle cells via Akt-p38 MAPK-JNK signaling
Int. J. Biochem. Cell Biol.
62
15-23
2015
Homo sapiens (P13674), Homo sapiens, Rattus norvegicus (P54001), Rattus norvegicus Wistar (P54001)
Timmins, A.; Saint-Andre, M.; de Visser, S.P.
Understanding how prolyl-4-hydroxylase structure steers a ferryl oxidant toward scission of a strong C-H bond
J. Am. Chem. Soc.
139
9855-9866
2017
Homo sapiens (P13674), Homo sapiens
Shi, R.; Gao, S.; Zhang, J.; Xu, J.; Graham, L.; Yang, X.; Li, C.
Collagen prolyl 4-hydroxylases modify tumor progression
Acta Biochim. Biophys. Sin. (Shanghai)
53
805-814
2021
Homo sapiens (O15460), Homo sapiens (P13674), Homo sapiens (Q7Z4N8)
Vasta, J.D.; Choudhary, A.; Jensen, K.H.; McGrath, N.A.; Raines, R.T.
Prolyl 4-hydroxylase substrate isosteres in which an (E)- or (Z)-alkene replaces the prolyl peptide bond
Biochemistry
56
219-227
2017
Chlamydomonas reinhardtii (A8IDI8), Chlamydomonas reinhardtii, Homo sapiens (P13674), Homo sapiens
Vasta, J.D.; Raines, R.T.
Collagen prolyl 4-hydroxylase as a therapeutic target
J. Med. Chem.
61
10403-10411
2018
Gallus gallus, Homo sapiens
Xiong, G.; Stewart, R.L.; Chen, J.; Gao, T.; Scott, T.L.; Samayoa, L.M.; OConnor, K.; Lane, A.N.; Xu, R.
Collagen prolyl 4-hydroxylase 1 is essential for HIF-1alpha stabilization and TNBC chemoresistance
Nat. Commun.
9
4456
2018
Homo sapiens (P13674), Homo sapiens
Murthy, A.V.; Sulu, R.; Koski, M.K.; Tu, H.; Anantharajan, J.; Sah-Teli, S.K.; Myllyharju, J.; Wierenga, R.K.
Structural enzymology binding studies of the peptide-substrate-binding domain of human collagen prolyl 4-hydroxylase (type-II) High affinity peptides have a PxGP sequence motif
Protein Sci.
27
1692-1703
2018
Homo sapiens (O15460), Homo sapiens
