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Information on EC 1.1.1.22 - UDP-glucose 6-dehydrogenase
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1.1.1.22 UDP-glucose 6-dehydrogenaseIUBMB Comments
Also acts on UDP-alpha-D-2-deoxyglucose.
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Word Map
- 1.1.1.22
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udp-glucuronic
- polysaccharide
- glycosaminoglycans
- hyaluronan
- udp-xylose
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pyrophosphorylase
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glucuronidation
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glucuronic
- exopolysaccharide
- udp-glca
- udp-sugars
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udp-glucuronyltransferase
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glca
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udpga
- udp-d-glucuronate
- agriculture
- pharmacology
- synthesis
- molecular biology
- medicine
The enzyme appears in viruses and cellular organisms
Synonyms
ADH-like UDP-glucose dehydrogenase, AglM, BceC, dehydrogenase, uridine diphosphoglucose, dual specificity UDP-glucose dehydrogenase, GbUGD, HasB, HasB2, HVO_1531, PA2022, 
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topREACTION 
REACTION DIAGRAM
COMMENTARY 
ORGANISM
UNIPROT
LITERATURE
UDP-alpha-D-glucose + 2 NAD+ + H2O = UDP-alpha-D-glucuronate + 2 NADH + 2 H+
reaction mechanism, C275 provides SH-group in the catalytic centre
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UDP-alpha-D-glucose + 2 NAD+ + H2O = UDP-alpha-D-glucuronate + 2 NADH + 2 H+
two-step reaction, reaction mechanism
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UDP-alpha-D-glucose + 2 NAD+ + H2O = UDP-alpha-D-glucuronate + 2 NADH + 2 H+
ping-pong reaction mechanism
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UDP-alpha-D-glucose + 2 NAD+ + H2O = UDP-alpha-D-glucuronate + 2 NADH + 2 H+
also shows aldehyde dehydrogenase activity
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UDP-alpha-D-glucose + 2 NAD+ + H2O = UDP-alpha-D-glucuronate + 2 NADH + 2 H+
also shows alcohol dehydrogenase activity
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UDP-alpha-D-glucose + 2 NAD+ + H2O = UDP-alpha-D-glucuronate + 2 NADH + 2 H+
also shows alcohol dehydrogenase activity
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UDP-alpha-D-glucose + 2 NAD+ + H2O = UDP-alpha-D-glucuronate + 2 NADH + 2 H+
bi-uni-uni-bi mechanism
Saccharum spp.
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UDP-alpha-D-glucose + 2 NAD+ + H2O = UDP-alpha-D-glucuronate + 2 NADH + 2 H+
mechanism, ordered water molecule H-bonded to T118 serves as catalytic base in hydride transfer
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UDP-alpha-D-glucose + 2 NAD+ + H2O = UDP-alpha-D-glucuronate + 2 NADH + 2 H+
the enzyme is also binds RNA and acts as a ribonuclease
UDP-alpha-D-glucose + 2 NAD+ + H2O = UDP-alpha-D-glucuronate + 2 NADH + 2 H+
the enzyme is also binds RNA and acts as a ribonuclease
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UDP-alpha-D-glucose + 2 NAD+ + H2O = UDP-alpha-D-glucuronate + 2 NADH + 2 H+
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PATHWAY SOURCE
PATHWAYS
BRENDA
KEGG