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Literature summary for 1.1.1.22 extracted from

  • Riegert, A.; Raushel, F.
    Functional and structural characterization of the UDP-glucose dehydrogenase involved in capsular polysaccharide biosynthesis from Campylobacter jejuni (2021), Biochemistry, 60, 725-734 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.22

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Campylobacter jejuni subsp. jejuni

Crystallization (Commentary)

Crystallization (Comment) Organism
structure in the presence of NAD+ and UDP-glucose bound in the active site Campylobacter jejuni subsp. jejuni

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.19
-
 UDP-alpha-D-glucose pH 8.7, 25°C Campylobacter jejuni subsp. jejuni
0.21
-
 NAD+ pH 8.7, 25°C Campylobacter jejuni subsp. jejuni

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Campylobacter jejuni subsp. jejuni Q0P8H3 serotype O:2
-
Campylobacter jejuni subsp. jejuni ATCC 700819 Q0P8H3 serotype O:2
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information no amide products are found in the presence of added amines. The addition of either ethanolamine, ethanolamine phosphate, serinol, or serinol phosphate has no measurable effect on the catalytic properties Campylobacter jejuni subsp. jejuni ?
-
-
additional information no amide products are found in the presence of added amines. The addition of either ethanolamine, ethanolamine phosphate, serinol, or serinol phosphate has no measurable effect on the catalytic properties Campylobacter jejuni subsp. jejuni ATCC 700819 ?
-
-
UDP-alpha-D-glucose + 2 NAD+ + H2O
-
 Campylobacter jejuni subsp. jejuni UDP-alpha-D-glucuronate + 2 NADH + 2 H+
-
 ?
UDP-alpha-D-glucose + 2 NAD+ + H2O
-
 Campylobacter jejuni subsp. jejuni ATCC 700819 UDP-alpha-D-glucuronate + 2 NADH + 2 H+
-
 ?

Synonyms

Synonyms Comment Organism
Cj1441c
-
 Campylobacter jejuni subsp. jejuni
kfiD
-
 Campylobacter jejuni subsp. jejuni

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.8
-
 NAD+ pH 8.7, 25°C Campylobacter jejuni subsp. jejuni
1.1
-
 UDP-alpha-D-glucose pH 8.7, 25°C Campylobacter jejuni subsp. jejuni

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Campylobacter jejuni subsp. jejuni

General Information

General Information Comment Organism
physiological function enzyme is involved in capsular polysaccharide biosynthesis Campylobacter jejuni subsp. jejuni

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
4.2
-
 UDP-alpha-D-glucose pH 8.7, 25°C Campylobacter jejuni subsp. jejuni
4.8
-
 NAD+ pH 8.7, 25°C Campylobacter jejuni subsp. jejuni