Literature summary for 1.1.1.22 extracted from

Chen, J.; Yu, Y.; Gao, J.; Yang, S.
UDP-glucose dehydrogenase The first-step oxidation is an NAD+-dependent bimolecular nucleophilic substitution reaction (SN2) (2019), Int. J. Biol. Sci., 15, 341-350 .

Search for more literature for 1.1.1.22

Cloned(Commentary)

Cloned (Comment)	Organism
-	Streptococcus equi subsp. zooepidemicus

Protein Variants

Protein Variants	Comment	Organism
C260A	mutation of the essential Cys residue. The C260A mutant and wild-type are then co-expressed in vivo via a single-crossover homologous recombination method. The resulting strain produces an amide derivative of hyaluronan	Streptococcus equi subsp. zooepidemicus

Organism

Organism	UniProt	Comment	Textmining
Streptococcus equi subsp. zooepidemicus	-	-	-

Synonyms

Synonyms	Comment	Organism
UGDH	-	Streptococcus equi subsp. zooepidemicus

General Information

General Information	Comment	Organism
metabolism	enzyme displays a NAD+-dependent SN2 mechanism. The first oxidation involves the nucleophilic addition of the essential Cys residue. The acceptor of C6-OH of UDP-glucose is an ordered H2O molecule. The second NADH is released after hydrolysis of the thioester intermediate	Streptococcus equi subsp. zooepidemicus

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Release 2023.1 (January 2023)