Literature summary for 1.1.1.22 extracted from

Beattie, N.R.; Keul, N.D.; Hicks Sirmans, T.N.; McDonald, W.E.; Talmadge, T.M.; Taujale, R.; Kannan, N.; Wood, Z.A.
Conservation of atypical allostery in C. elegans UDP-glucose dehydrogenase (2019), ACS omega, 4, 16318-16329 .

Crystallization (Commentary)

Crystallization (Comment)	Organism
structures of unliganded and UDP-xylose bound UGDH. The A109P substitution that differs human and Caenorhabditis elgans enzymes is accommodated by an Asn-to-Ser substitution at position 290. The allosteric transition is conserved in UGDH, and UDP-Xyl binding induces formation of the Eomega hexamer. The enzyme also exhibits hysteresis in progress curves and negative cooperativity with respect to NAD+ binding	Caenorhabditis elegans

Crystallization (Comment)

Organism

structures of unliganded and UDP-xylose bound UGDH. The A109P substitution that differs human and Caenorhabditis elgans enzymes is accommodated by an Asn-to-Ser substitution at position 290. The allosteric transition is conserved in UGDH, and UDP-Xyl binding induces formation of the Eomega hexamer. The enzyme also exhibits hysteresis in progress curves and negative cooperativity with respect to NAD+ binding

Caenorhabditis elegans

Inhibitors

Inhibitors	Comment	Organism	Structure
UDP-xylose	-	Caenorhabditis elegans

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.055	-	UDP-alpha-D-glucose	Hill coefficient 1, pH 7.5, 25°C	Caenorhabditis elegans
0.333	-	NAD+	K0.5 value, Hill coefficient 0.8, pH 7.5, 25°C	Caenorhabditis elegans

Organism

Organism	UniProt	Comment	Textmining
Caenorhabditis elegans	Q19905	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
UDP-alpha-D-glucose + 2 NAD+ + H2O	-	Caenorhabditis elegans	UDP-alpha-D-glucuronate + 2 NADH + 2 H+	-	?

Synonyms

Synonyms	Comment	Organism
sqv-4	-	Caenorhabditis elegans
UGDH	-	Caenorhabditis elegans

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
1.23	-	UDP-alpha-D-glucose	pH 7.5, 25°C	Caenorhabditis elegans
1.7	-	NAD+	Hill coefficient 0.8, pH 7.5, 25°C	Caenorhabditis elegans

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0069	-	UDP-xylose	pH 7.5, 25°C	Caenorhabditis elegans