BRENDA - Enzyme Database
show all sequences of 1.1.1.22

The UDP-glucose dehydrogenase of Escherichia coli K-12 displays substrate inhibition by NAD that is relieved by nucleotide triphosphates

Mainprize, I.L.; Bean, J.D.; Bouwman, C.; Kimber, M.S.; Whitfield, C.; J. Biol. Chem. 288, 23064-23074 (2013)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
ADP
slight activation
Escherichia coli
AMPPNP
-
Escherichia coli
ATP
; highly activating
Escherichia coli
dATP
highly activating
Escherichia coli
diphosphate
-
Escherichia coli
additional information
the enzyme shows a mechanism of activation that is NTP-dependent, poor activation by UDP-alpha-D-glucose. The inclusion of MgCl2 in the reaction buffer reverses the NTP-dependent activation of UgdK-12, in a concentration-dependent manner. This is not specific to Mg2+ as a similar effect is found for other divalent cations, including Ca2+, Mn2+, Zn2+, and Ni2+. Monovalent cations do not affect UgdK-12 activity. Chelating the divalent cation with EDTA or EGTA restores the NTP-dependent activation of UgdK-12
Escherichia coli
UDP
slight activation
Escherichia coli
UTP
best activating nucleotide triphosphate
Escherichia coli
Cloned(Commentary)
Cloned (Commentary)
Organism
gene ugd, located near the colanic acid/group 1 CPS locus, recombinant overexpression of His6-tagged enzyme in Escherichia coli strain CWG876; gene ugd, located near the colanic acid/group 1 CPS locus, recombinant overexpression of His6-tagged full-length enzyme and truncated enzyme comprising residues 447-704 in Escherichia coli strain CWG876
Escherichia coli
Engineering
Protein Variants
Commentary
Organism
K323A
site-directed mutagenesis, the mutant shows altered kinetics compared to the wild-type enzyme
Escherichia coli
additional information
enzyme Ugd from Escherichia coli K-12 can functionally replace enzyme Ugd from Escherichia coli serotype K30 in biosynthesis of K30 capsular polysaccharide
Escherichia coli
R324A
site-directed mutagenesis, the mutant purifies in much lower amounts relative to wild-type and is prone to degradation and has negligible activity
Escherichia coli
Y71F
site-directed mutagenesis, the mutant shows unaltered catalytic activity
Escherichia coli
Inhibitors
Inhibitors
Commentary
Organism
Structure
additional information
the enzyme from serotype K30 is not inhibited by NAD+, in contrast to Escherichia coli K-12
Escherichia coli
NAD+
substrate inhibition, reversible by the addition of a nucleotide triphosphate, e.g. ATP, in the absence of kinase. Mutations in a previously identified UDP-glucuronic acid allosteric binding site decrease the binding affinity of the nucleotide triphosphate
Escherichia coli
UDP-alpha-D-glucuronate
slight product inhibition
Escherichia coli
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
Michaelis-Menten kinetics
Escherichia coli
0.31
-
NAD+
pH 9.5, 37C, recombinant wild-type enzyme
Escherichia coli
0.35
0.62
NAD+
pH 9.5, 37C, recombinant wild-type enzyme, from different strains; pH 9.5, 37C, recombinant wild-type enzyme, with 0.025-1.0 mM ATP
Escherichia coli
0.43
-
NAD+
pH 9.5, 37C, recombinant mutant K323A
Escherichia coli
0.5
-
NAD+
pH 9.5, 37C, recombinant mutant Y71F
Escherichia coli
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
UDP-alpha-D-glucose + 2 NAD+ + H2O
Escherichia coli
-
UDP-alpha-D-glucuronate + 2 NADH + 2 H+
-
-
?
Organism
Organism
UniProt
Commentary
Textmining
Escherichia coli
-
serotype K30, several strains; several strains
-
Posttranslational Modification
Posttranslational Modification
Commentary
Organism
phosphoprotein
possible role of Ugd phosphorylation in the production of a constitutively expressed capsular polysaccharide, no role for phosphorylation in modulating activity of Ugd. Escherichia coli might contain two bacterial tyrosine kinases, analysis of kinase deletion mutants of Escherichia coli strains, overview; tyrosine phosphorylation in the activation of Ugd of Escherichia coli K12. Possible role of Ugd phosphorylation in the production of a constitutively expressed capsular polysaccharide (CPS), no role for phosphorylation in modulating activity of Ugd. Escherichia coli might contain two bacterial tyrosine kinases, analysis of kinase deletion mutants of Escherichia coli strains, overview
Escherichia coli
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
UDP-alpha-D-glucose + 2 NAD+ + H2O
-
740710
Escherichia coli
UDP-alpha-D-glucuronate + 2 NADH + 2 H+
-
-
-
?
Subunits
Subunits
Commentary
Organism
More
structural modelling of the enzyme in complex with NAD and uridine 5'-monophosphate, using structure of Ugd from Klebsiella pneumoniae in complex with UDPGA, PDB ID 3PJG, as template
Escherichia coli
Synonyms
Synonyms
Commentary
Organism
UDP-glucose dehydrogenase
-
Escherichia coli
Ugd
-
Escherichia coli
Temperature Optimum [C]
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
37
-
assay at
Escherichia coli
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
2.7
-
NAD+
pH 9.5, 37C, recombinant mutant K323A
Escherichia coli
4.2
-
NAD+
pH 9.5, 37C, recombinant wild-type enzyme
Escherichia coli
5.4
7.1
NAD+
pH 9.5, 37C, recombinant wild-type enzyme, from different strains
Escherichia coli
7.3
-
NAD+
pH 9.5, 37C, recombinant mutant Y71F
Escherichia coli
56.2
-
NAD+
pH 9.5, 37C, recombinant wild-type enzyme, with 0.025-1.0 mM ATP
Escherichia coli
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
9.5
-
assay at
Escherichia coli
Cofactor
Cofactor
Commentary
Organism
Structure
NAD+
-
Escherichia coli
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
ADP
slight activation
Escherichia coli
AMPPNP
-
Escherichia coli
ATP
; highly activating
Escherichia coli
dATP
highly activating
Escherichia coli
diphosphate
-
Escherichia coli
additional information
the enzyme shows a mechanism of activation that is NTP-dependent, poor activation by UDP-alpha-D-glucose. The inclusion of MgCl2 in the reaction buffer reverses the NTP-dependent activation of UgdK-12, in a concentration-dependent manner. This is not specific to Mg2+ as a similar effect is found for other divalent cations, including Ca2+, Mn2+, Zn2+, and Ni2+. Monovalent cations do not affect UgdK-12 activity. Chelating the divalent cation with EDTA or EGTA restores the NTP-dependent activation of UgdK-12
Escherichia coli
UDP
slight activation
Escherichia coli
UTP
best activating nucleotide triphosphate
Escherichia coli
Cloned(Commentary) (protein specific)
Commentary
Organism
gene ugd, located near the colanic acid/group 1 CPS locus, recombinant overexpression of His6-tagged enzyme in Escherichia coli strain CWG876; gene ugd, located near the colanic acid/group 1 CPS locus, recombinant overexpression of His6-tagged full-length enzyme and truncated enzyme comprising residues 447-704 in Escherichia coli strain CWG876
Escherichia coli
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NAD+
-
Escherichia coli
Engineering (protein specific)
Protein Variants
Commentary
Organism
K323A
site-directed mutagenesis, the mutant shows altered kinetics compared to the wild-type enzyme
Escherichia coli
additional information
enzyme Ugd from Escherichia coli K-12 can functionally replace enzyme Ugd from Escherichia coli serotype K30 in biosynthesis of K30 capsular polysaccharide
Escherichia coli
R324A
site-directed mutagenesis, the mutant purifies in much lower amounts relative to wild-type and is prone to degradation and has negligible activity
Escherichia coli
Y71F
site-directed mutagenesis, the mutant shows unaltered catalytic activity
Escherichia coli
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
additional information
the enzyme from serotype K30 is not inhibited by NAD+, in contrast to Escherichia coli K-12
Escherichia coli
NAD+
substrate inhibition, reversible by the addition of a nucleotide triphosphate, e.g. ATP, in the absence of kinase. Mutations in a previously identified UDP-glucuronic acid allosteric binding site decrease the binding affinity of the nucleotide triphosphate
Escherichia coli
UDP-alpha-D-glucuronate
slight product inhibition
Escherichia coli
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
Michaelis-Menten kinetics
Escherichia coli
0.31
-
NAD+
pH 9.5, 37C, recombinant wild-type enzyme
Escherichia coli
0.35
0.62
NAD+
pH 9.5, 37C, recombinant wild-type enzyme, from different strains; pH 9.5, 37C, recombinant wild-type enzyme, with 0.025-1.0 mM ATP
Escherichia coli
0.43
-
NAD+
pH 9.5, 37C, recombinant mutant K323A
Escherichia coli
0.5
-
NAD+
pH 9.5, 37C, recombinant mutant Y71F
Escherichia coli
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
UDP-alpha-D-glucose + 2 NAD+ + H2O
Escherichia coli
-
UDP-alpha-D-glucuronate + 2 NADH + 2 H+
-
-
?
Posttranslational Modification (protein specific)
Posttranslational Modification
Commentary
Organism
phosphoprotein
possible role of Ugd phosphorylation in the production of a constitutively expressed capsular polysaccharide, no role for phosphorylation in modulating activity of Ugd. Escherichia coli might contain two bacterial tyrosine kinases, analysis of kinase deletion mutants of Escherichia coli strains, overview; tyrosine phosphorylation in the activation of Ugd of Escherichia coli K12. Possible role of Ugd phosphorylation in the production of a constitutively expressed capsular polysaccharide (CPS), no role for phosphorylation in modulating activity of Ugd. Escherichia coli might contain two bacterial tyrosine kinases, analysis of kinase deletion mutants of Escherichia coli strains, overview
Escherichia coli
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
UDP-alpha-D-glucose + 2 NAD+ + H2O
-
740710
Escherichia coli
UDP-alpha-D-glucuronate + 2 NADH + 2 H+
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
More
structural modelling of the enzyme in complex with NAD and uridine 5'-monophosphate, using structure of Ugd from Klebsiella pneumoniae in complex with UDPGA, PDB ID 3PJG, as template
Escherichia coli
Temperature Optimum [C] (protein specific)
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
37
-
assay at
Escherichia coli
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
2.7
-
NAD+
pH 9.5, 37C, recombinant mutant K323A
Escherichia coli
4.2
-
NAD+
pH 9.5, 37C, recombinant wild-type enzyme
Escherichia coli
5.4
7.1
NAD+
pH 9.5, 37C, recombinant wild-type enzyme, from different strains
Escherichia coli
7.3
-
NAD+
pH 9.5, 37C, recombinant mutant Y71F
Escherichia coli
56.2
-
NAD+
pH 9.5, 37C, recombinant wild-type enzyme, with 0.025-1.0 mM ATP
Escherichia coli
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
9.5
-
assay at
Escherichia coli
General Information
General Information
Commentary
Organism
additional information
enzyme Ugd from Escherichia coli K-12 can functionally replace enzyme Ugd from Escherichia coli serotype K30 in biosynthesis of K30 capsular polysaccharide
Escherichia coli
physiological function
in Escherichia coli K-12, Ugd is important for biosynthesis of the environmentally regulated exopolysaccharide known as colanic acid, whereas in other Escherichia coli isolates, the same enzyme is required for production of the constitutive group 1 capsular polysaccharides, which act as virulence determinants; in Escherichia coli serotype K30, the enzyme is required for production of the constitutive group 1 capsular polysaccharides, which act as virulence determinants
Escherichia coli
General Information (protein specific)
General Information
Commentary
Organism
additional information
enzyme Ugd from Escherichia coli K-12 can functionally replace enzyme Ugd from Escherichia coli serotype K30 in biosynthesis of K30 capsular polysaccharide
Escherichia coli
physiological function
in Escherichia coli K-12, Ugd is important for biosynthesis of the environmentally regulated exopolysaccharide known as colanic acid, whereas in other Escherichia coli isolates, the same enzyme is required for production of the constitutive group 1 capsular polysaccharides, which act as virulence determinants; in Escherichia coli serotype K30, the enzyme is required for production of the constitutive group 1 capsular polysaccharides, which act as virulence determinants
Escherichia coli
Other publictions for EC
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
740128
Li
-
Overexpression of UDP-glucose ...
Larix gmelinii
Biol. Plant.
61
95-105
2017
-
-
1
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
4
-
-
2
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
740935
Kandiba
AglM and VNG1048G, two haloarc ...
Halobacterium salinarum, Halobacterium salinarum ATCC 700922, Haloferax volcanii, Haloferax volcanii ATCC 29605
Life
6
pii: E31
2016
-
-
2
-
-
-
1
-
-
1
5
4
-
6
-
-
2
-
-
2
1
-
4
5
8
-
-
-
-
2
-
-
2
-
-
-
-
-
2
2
-
-
-
-
1
-
-
-
1
5
4
-
-
-
2
-
2
1
-
4
5
-
-
-
-
2
-
-
-
-
5
5
-
-
-
739891
Wu
Biochemical characterization a ...
Sphingomonas sanxanigenens, Sphingomonas sanxanigenens NX02
Appl. Biochem. Microbiol.
51
27-33
2015
-
-
1
-
1
-
-
3
-
-
1
2
-
7
-
-
1
-
-
-
-
-
4
1
2
1
1
1
2
1
1
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
3
-
-
1
2
-
-
-
1
-
-
-
-
4
1
1
1
1
2
1
1
-
-
-
3
3
-
2
2
741372
Wei
Discovery and biochemical char ...
Granulibacter bethesdensis
Protein Pept. Lett.
22
628-634
2015
-
2
1
-
-
-
4
-
-
-
-
1
-
4
-
-
1
-
-
-
-
-
2
-
3
1
-
-
-
1
-
-
2
-
-
-
-
2
1
2
-
-
-
-
4
-
-
-
-
-
1
-
-
-
1
-
-
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
739967
Wen
UDP-glucose dehydrogenase modu ...
Homo sapiens, Rattus norvegicus, Rattus norvegicus Wistar
Arthritis Res. Ther.
16
484-494
2014
-
-
2
-
1
-
-
-
-
-
-
3
-
3
-
-
-
-
-
4
-
-
3
-
5
-
-
-
-
-
-
-
2
-
-
-
-
-
2
2
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
4
-
-
3
-
-
-
-
-
-
-
-
-
1
4
4
1
-
-
724370
Kadirvelraj
Hysteresis and negative cooper ...
Homo sapiens
Biochemistry
52
1456-1465
2013
-
-
-
-
1
-
-
4
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
4
-
-
-
-
-
1
1
-
-
-
726483
Sato
-
Possible role of a peach homol ...
Prunus persica
Sci. Hortic.
150
195-200
2013
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
3
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
739981
Barbas
Rossmann-fold motifs can confe ...
Sphingomonas elodea, Sphingomonas elodea ATCC 31461
Biochem. Biophys. Res. Commun.
430
218-224
2013
-
-
1
-
-
-
-
-
-
-
2
2
-
4
-
-
1
1
-
-
-
-
4
2
2
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
2
2
-
-
-
1
-
-
-
-
4
2
-
-
-
-
-
-
-
-
-
2
2
-
-
-
740710
Mainprize
The UDP-glucose dehydrogenase ...
Escherichia coli
J. Biol. Chem.
288
23064-23074
2013
8
-
1
-
4
-
3
5
-
-
-
1
-
3
-
1
-
-
-
-
-
-
1
1
2
1
-
-
5
1
-
-
1
-
-
-
8
-
1
1
-
4
-
-
3
-
5
-
-
-
1
-
-
1
-
-
-
-
-
1
1
1
-
-
5
1
-
-
-
-
2
2
-
-
-
740715
Hyde
UDP-glucose dehydrogenase acti ...
Homo sapiens
J. Biol. Chem.
288
35049-35057
2013
-
1
1
-
4
1
1
7
-
-
1
2
-
1
-
-
1
-
-
1
-
-
2
2
2
1
-
1
-
1
-
-
1
-
-
-
-
1
1
1
-
4
1
-
1
-
7
-
-
1
2
-
-
-
1
-
1
-
-
2
2
1
-
1
-
1
-
-
-
-
2
2
-
-
-
721215
Sakuraba
Structure of a UDP-glucose deh ...
Pyrobaculum islandicum
Acta Crystallogr. Sect. F
68
1003-1007
2012
-
-
-
1
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
724364
Sennett
Cofactor binding triggers a mo ...
Homo sapiens
Biochemistry
51
9364-9374
2012
-
-
1
1
1
-
-
4
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
4
-
-
-
1
-
-
-
-
-
1
1
1
1
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
725276
Cole
A conserved UDP-glucose dehydr ...
Streptococcus pyogenes, Streptococcus pyogenes 5448, Streptococcus pyogenes M1 GAS, Streptococcus pyogenes M1 GAS 5448
J. Bacteriol.
194
6154-6161
2012
-
-
-
-
-
-
-
-
1
-
2
-
-
6
-
-
-
-
-
-
-
-
2
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
2
2
-
-
-
725478
Egger
Structural and kinetic evidenc ...
Homo sapiens
J. Biol. Chem.
287
2119-2129
2012
-
-
1
1
5
-
-
4
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
-
1
-
-
-
-
-
1
1
1
5
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
4
4
721871
Satomura
Identification and characteriz ...
Pyrobaculum islandicum
Biosci. Biotechnol. Biochem.
75
2049-2051
2011
-
-
1
-
-
-
-
6
-
-
2
1
-
4
-
-
1
-
-
-
-
-
1
1
1
1
-
2
-
1
1
1
1
-
-
-
-
-
1
1
-
-
-
-
-
-
6
-
-
2
1
-
-
-
1
-
-
-
-
1
1
1
-
2
-
1
1
1
-
-
-
-
-
-
-
724328
Sennett
Conformational flexibility in ...
Homo sapiens
Biochemistry
50
9651-9663
2011
-
-
1
1
1
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
725260
Rocha
Structure of Burkholderia cepa ...
Burkholderia cepacia
J. Bacteriol.
193
3978-3987
2011
-
-
1
1
3
-
-
2
-
-
-
-
-
4
-
-
-
-
-
-
-
-
1
-
1
1
2
-
2
1
1
-
-
-
-
-
-
-
1
-
1
3
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
2
-
2
1
1
-
-
-
-
-
-
-
-
725729
Banerjee
-
UDP-glucose dehydrogenase from ...
Capra hircus
J. Mol. Catal. B
68
37-43
2011
-
-
-
-
-
-
5
2
-
-
2
-
-
1
-
-
1
-
-
1
1
-
2
1
-
1
-
-
-
1
1
1
2
-
-
-
-
-
-
2
-
-
-
-
5
-
2
-
-
2
-
-
-
-
1
-
1
1
-
2
1
1
-
-
-
1
1
1
-
-
-
-
-
-
-
726278
Rajakannan
Structural basis of cooperativ ...
Homo sapiens
PLoS ONE
6
e25226
2011
-
-
-
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
726412
Zhou
-
Cloning, expression and bioche ...
Phoma herbarum, Phoma herbarum YS4108
Process Biochem.
46
2263-2268
2011
-
-
1
-
-
-
-
2
-
-
2
-
-
2
-
-
-
-
-
-
-
-
2
1
1
1
1
-
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
2
1
1
1
-
-
1
1
-
-
-
-
-
-
-
-
710750
Rocha
Cloning, expression, purificat ...
Burkholderia cepacia, Burkholderia cepacia IST408
Acta Crystallogr. Sect. F
66
269-271
2010
-
-
1
1
-
-
-
-
-
-
1
2
-
8
-
-
1
-
-
-
-
-
2
1
3
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
1
-
-
-
-
-
-
-
-
1
2
-
-
-
1
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
710762
Rocha
Cloning, expression, purificat ...
Sphingomonas elodea, Sphingomonas elodea ATCC 31461
Acta Crystallogr. Sect. F
66
69-72
2010
-
-
1
1
-
-
-
-
-
-
-
2
-
5
-
-
1
-
-
-
-
-
2
-
3
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
1
-
-
-
-
-
-
-
-
-
2
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
710889
Jiang
Characterization of UDP-glucos ...
Proteus mirabilis
Antimicrob. Agents Chemother.
54
2000-2009
2010
-
-
-
-
1
-
-
-
-
-
-
1
-
4
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
728319
Yurist-Doutsch
N-glycosylation in Archaea: on ...
Haloferax volcanii, Haloferax volcanii DSM 3757
Mol. Microbiol.
75
1047-1058
2010
-
-
-
-
-
-
-
-
-
1
-
2
-
7
-
-
-
-
-
-
-
-
8
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
8
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
695880
Lee
Computational analysis of the ...
Homo sapiens
Arch. Biochem. Biophys.
486
35-43
2009
-
-
-
1
8
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
698005
Ariyakumar
Characterization of two host-s ...
Aliivibrio fischeri
FEMS Microbiol. Lett.
299
65-73
2009
-
-
-
-
1
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
698331
Huang
UDP-glucose dehydrogenase as a ...
Homo sapiens
Int. J. Cancer
126
315-327
2009
-
1
1
-
-
-
-
-
-
-
-
-
-
3
-
-
1
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
698529
Sheng
Use of induction promoters to ...
Streptococcus equi subsp. zooepidemicus, Streptococcus equi subsp. zooepidemicus FHA0
J. Appl. Microbiol.
107
136-144
2009
2
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
700059
Loutet
Contributions of two UDP-gluco ...
Burkholderia cenocepacia J2315
Microbiology
155
2029-2039
2009
-
-
1
-
1
-
-
3
-
-
3
-
-
5
-
-
1
-
-
-
-
-
5
1
6
-
-
-
4
-
-
-
-
-
-
-
-
-
3
-
-
3
-
-
-
-
4
-
-
3
-
-
-
-
3
-
-
-
-
5
2
-
-
-
4
-
-
-
-
-
-
-
-
-
-
700488
Siddique
Myo-inositol oxygenase genes a ...
Arabidopsis thaliana
New Phytol.
184
457-472
2009
-
-
1
-
-
-
-
-
-
-
-
-
-
9
-
-
-
-
-
2
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
711665
Wei
Androgen-stimulated UDP-glucos ...
Homo sapiens
Cancer Res.
69
2332-2339
2009
-
-
1
-
2
-
-
-
-
-
-
1
-
2
-
-
1
-
-
5
-
-
1
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
1
-
5
-
-
1
-
-
-
-
-
-
-
-
-
1
2
2
1
-
-
690024
Maneix
17Beta-oestradiol up-regulates ...
Oryctolagus cuniculus
Rheumatology
47
281-288
2008
2
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697937
Hwang
Inhibitory effects of gallic a ...
Homo sapiens
FEBS Lett.
582
3793-3797
2008
-
1
-
-
-
-
2
2
-
-
-
-
-
2
-
-
1
-
-
1
3
-
1
-
2
-
-
-
-
-
-
-
-
4
-
-
-
1
-
-
-
-
-
-
2
4
2
-
-
-
-
-
-
-
1
-
1
3
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
684611
Granja
Biochemical characterization a ...
Sphingomonas elodea
Appl. Microbiol. Biotechnol.
76
1319-1327
2007
-
-
1
-
-
-
-
2
-
-
1
-
-
8
-
-
-
-
-
-
-
-
1
1
1
1
1
-
2
1
1
-
2
-
-
-
-
-
1
2
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
1
1
1
1
-
2
1
1
-
-
-
-
-
-
-
-
685143
Easley
Characterization of human UDP- ...
Homo sapiens
Biochemistry
46
369-378
2007
-
-
-
-
9
-
-
6
-
-
-
-
-
3
-
-
-
-
-
-
10
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
9
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
10
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687474
Huh
Alteration of the quaternary s ...
Homo sapiens
J. Biochem. Mol. Biol.
40
690-696
2007
-
-
-
-
1
-
-
4
-
-
3
-
-
3
-
-
-
-
-
-
-
-
1
3
-
-
-
-
2
-
-
-
2
-
-
-
-
-
-
2
-
1
-
-
-
-
4
-
-
3
-
-
-
-
-
-
-
-
-
1
3
-
-
-
2
-
-
-
-
-
-
-
-
-
-
687559
Hung
Comparative analysis of two UD ...
Pseudomonas aeruginosa
J. Biol. Chem.
282
17738-17748
2007
-
-
1
-
1
-
5
4
-
-
4
-
-
5
-
-
-
-
-
-
-
-
7
1
2
-
-
-
4
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
7
-
4
-
-
4
-
-
-
-
-
-
-
-
-
7
2
-
-
-
4
-
-
-
-
-
-
-
-
-
-
688084
Klinghammer
Genome-wide analysis of the UD ...
Arabidopsis thaliana
J. Exp. Bot.
58
3609-3621
2007
-
-
1
-
-
-
1
6
1
-
-
-
-
5
-
-
-
-
-
-
-
-
2
-
-
-
-
-
3
-
-
-
2
3
-
-
-
-
1
2
-
-
-
-
1
3
6
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
669522
Vigetti
Molecular cloning and characte ...
Xenopus laevis
J. Biol. Chem.
281
8254-8263
2006
-
-
1
-
-
-
-
2
-
-
-
1
-
3
-
-
1
-
-
1
-
-
2
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
2
-
-
-
1
-
-
-
1
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
670630
Kaerkoenen
Novel characteristics of UDP-g ...
Zea mays
Planta
223
858-870
2006
-
-
-
-
-
-
-
-
1
-
-
1
-
3
-
-
-
-
-
2
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
670814
Huh
Expression, purification, crys ...
Homo sapiens
Protein Pept. Lett.
13
859-862
2006
-
-
-
1
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
666609
Bindschedler
Characterisation and expressio ...
Nicotiana tabacum
Plant Mol. Biol.
57
285-301
2005
-
-
1
-
-
-
-
-
-
-
1
-
-
4
-
-
1
-
-
-
1
-
1
1
3
-
-
-
-
-
-
-
2
-
-
-
-
-
1
2
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667414
Beauchef
c-Krox down-regulates the expr ...
Oryctolagus cuniculus
Biochem. Biophys. Res. Commun.
333
1123-1131
2005
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667513
Kaerkoenen
UDP-glucose dehydrogenases of ...
Zea mays
Biochem. J.
391
409-415
2005
-
-
-
-
-
-
-
2
-
-
-
1
-
4
-
-
-
-
-
1
-
-
2
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667848
Huh
Identification of a UDP-glucos ...
Homo sapiens
Bioconjug. Chem.
16
710-716
2005
-
-
1
-
5
-
1
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
5
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
668055
Huh
Inhibition of human UDP-glucos ...
Homo sapiens
Biotechnol. Lett.
27
1229-1232
2005
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
655477
Ge
Active site residues and mecha ...
Streptococcus pyogenes
Eur. J. Biochem.
271
14-22
2004
-
-
-
-
4
-
-
9
-
-
-
-
-
2
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
1
-
4
-
-
-
-
9
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
656220
Sommer
Characterization of human UDP- ...
Homo sapiens
J. Biol. Chem.
279
23590-23596
2004
-
-
1
-
2
-
-
2
-
-
1
-
-
4
-
-
-
-
-
-
-
-
1
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
2
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
656240
Huh
Importance of Gly-13 for the c ...
Homo sapiens
J. Biol. Chem.
279
37491-37498
2004
-
-
-
-
1
-
-
2
-
-
2
-
-
4
-
-
-
-
-
-
-
-
1
2
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
654528
Roman
Overexpression of UDP-glucose ...
Escherichia coli
Biochem. J.
374
767-772
2003
-
-
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
654351
Turner
Purification and kinetic prope ...
Saccharum spp.
Arch. Biochem. Biophys.
407
209-216
2002
-
-
-
-
-
-
2
2
-
-
1
-
-
2
-
-
1
1
-
1
1
-
4
1
-
-
-
-
-
1
-
-
1
2
-
-
-
-
-
1
-
-
-
-
2
2
2
-
-
1
-
-
-
-
1
-
1
1
-
4
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
654831
Johansson
Molecular cloning and characte ...
Populus tremula x Populus tremuloides
Biochim. Biophys. Acta
1576
53-58
2002
-
-
1
-
-
-
-
-
1
-
1
-
-
6
-
-
-
-
-
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
657082
Hinterberg
-
Recombinant UDP-glucose dehydr ...
Glycine max
Plant Physiol. Biochem.
40
1011-1017
2002
-
-
-
-
-
-
3
2
-
-
1
-
-
1
-
-
-
-
-
-
-
-
2
1
-
1
-
1
-
1
-
-
1
1
-
-
-
-
-
1
-
-
-
-
3
1
2
-
-
1
-
-
-
-
-
-
-
-
-
2
1
1
-
1
-
1
-
-
-
-
-
-
-
-
-
657189
Hwang
The Caenorhabditis elegans vul ...
Caenorhabditis elegans
Proc. Natl. Acad. Sci. USA
99
14224-14229
2002
-
-
1
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
2
-
-
1
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286307
Stewart
-
Kinetic properties of UDP-gluc ...
Glycine max
Plant Sci.
147
119-125
1999
-
-
-
-
-
-
3
2
1
-
-
1
-
1
-
-
1
1
-
1
-
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
2
1
-
-
1
-
-
-
1
-
1
-
-
2
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
286301
Campbell
Properties and kinetic analysi ...
Streptococcus pyogenes
J. Biol. Chem.
272
3416-3422
1997
-
1
1
-
-
2
3
2
-
-
2
1
-
3
-
-
1
1
-
-
1
1
2
1
-
-
-
1
1
-
-
-
1
-
-
-
-
1
1
1
-
-
2
-
3
-
2
-
-
2
1
-
-
-
1
-
-
1
1
2
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
286302
Robertson
Inducible UDP-glucose dehydrog ...
Phaseolus vulgaris
Biochem. J.
313
311-317
1996
-
-
-
-
-
-
1
2
-
-
1
1
-
2
-
-
1
1
-
2
1
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
1
1
-
-
-
1
-
2
1
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286305
Sieberth
Expression and characterizatio ...
Escherichia coli
J. Bacteriol.
177
4562-4565
1995
-
-
1
-
-
-
-
2
2
-
2
1
-
4
-
-
1
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
2
2
-
2
1
-
-
-
1
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286306
Hempel
UDP-glucose dehydrogenase from ...
Bos taurus
Protein Sci.
3
1074-1080
1994
-
-
-
-
1
-
-
-
-
1
1
1
-
6
-
-
1
1
-
2
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
1
1
-
-
-
1
-
2
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286303
Reen
Impairment of UDP-glucose dehy ...
Cavia porcellus, Rattus norvegicus
Biochem. Pharmacol.
46
229-238
1993
-
-
-
-
-
-
2
2
1
-
-
2
-
4
-
-
1
-
-
9
-
-
5
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
2
1
-
-
2
-
-
-
1
-
9
-
-
5
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
286304
Grubb
Serum stimulation of UDP-gluco ...
Homo sapiens
Biochem. Mol. Biol. Int.
30
819-827
1993
1
-
-
-
-
-
2
2
-
-
-
1
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
2
-
2
-
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286290
Jaenicke
Dissociation and in vitro reco ...
Bos taurus
Biochemistry
25
7283-7287
1986
-
-
-
-
-
-
-
-
-
-
2
1
-
2
-
-
1
-
-
1
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
1
-
-
-
1
-
1
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286292
Schiller
UDP-glucose dehydrogenase from ...
Escherichia coli
Biochim. Biophys. Acta
453
418-425
1976
-
-
-
-
-
-
-
-
-
-
1
1
-
2
-
-
1
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
1
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286291
Druzhinina
Uridine diphosphate 2-deoxyglu ...
Bos taurus
Biochim. Biophys. Acta
381
301-307
1975
-
-
-
-
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
1
-
1
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
1
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286293
Schiller
Partial purification and prope ...
Escherichia coli
Biochim. Biophys. Acta
293
1-10
1973
3
-
-
-
-
2
3
2
-
-
1
1
-
2
-
-
1
-
-
-
-
1
16
-
-
1
-
-
-
1
1
-
1
-
-
-
3
-
-
1
-
-
2
-
3
-
2
-
-
1
1
-
-
-
1
-
-
-
1
16
-
1
-
-
-
1
1
-
-
-
-
-
-
-
-
286294
Davies
Properties of uridine diphosph ...
Lilium longiflorum
Arch. Biochem. Biophys.
152
53-61
1972
-
-
-
-
-
2
4
2
-
-
-
1
-
2
-
-
1
-
-
2
-
2
4
-
-
-
-
1
-
1
-
-
1
-
-
-
-
-
-
1
-
-
2
-
4
-
2
-
-
-
1
-
-
-
1
-
2
-
2
4
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
286295
Sivaswami
Uridine diphosphoglucose dehyd ...
Rattus norvegicus
Biochim. Biophys. Acta
276
43-52
1972
-
-
-
-
-
-
1
2
-
1
2
1
-
2
-
-
1
-
-
2
1
-
2
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
1
2
1
-
-
-
1
-
2
1
-
2
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
286296
Molz
Uridine diphosphate glucose de ...
Rattus norvegicus
Biochim. Biophys. Acta
250
6-13
1971
1
-
-
-
-
-
4
1
-
-
-
1
-
2
-
-
1
-
-
2
1
-
5
-
-
-
-
-
-
1
-
-
1
-
-
-
1
-
-
1
-
-
-
-
4
-
1
-
-
-
1
-
-
-
1
-
2
1
-
5
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
286297
Ankel
Biosynthesis of uridine diphos ...
Papiliotrema laurentii
Biochemistry
5
1864-1869
1966
1
-
-
-
-
-
4
1
-
-
-
1
-
3
-
-
1
-
-
-
1
-
11
-
-
-
-
-
-
1
1
-
1
-
-
-
1
-
-
1
-
-
-
-
4
-
1
-
-
-
1
-
-
-
1
-
-
1
-
11
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
286299
Neufeld
Inhibition of the UDP-D-glucos ...
Bos taurus, Gallus gallus, Pisum sativum
Biochem. Biophys. Res. Commun.
19
456-461
1965
-
-
-
-
-
-
3
-
-
-
-
3
-
3
-
-
-
-
-
2
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
3
-
-
-
-
-
2
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286298
Goldberg
pH dependence of the reactions ...
Bos taurus
J. Biol. Chem.
238
3109-3114
1963
-
-
-
-
-
-
-
1
-
-
-
1
-
1
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286300
Strominger
Enzymatic formation of uridine ...
Bos taurus
J. Biol. Chem.
224
79-90
1957
1
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
1
-
-
1
1
1
13
-
-
-
-
-
-
1
1
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
1
1
1
13
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-