Literature summary for 1.1.1.22 extracted from

Scoglio, S.; Lo Curcio, V.; Catalani, S.; Palma, F.; Battistelli, S.; Benedetti, S.
Inhibitory effects of Aphanizomenon flos-aquae constituents on human UDP-glucose dehydrogenase activity (2016), J. Enzyme Inhib. Med. Chem., 31, 1492-1497 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
phycocyanin	mixed-type inhibitor with respect to both UDP-glucose and NAD+	Homo sapiens
phycocyanobilin	competitive with respect to UDP-glucose and non-competitive with respect to NAD+. Phycocyanobilin is also effective in reducing the colony formation capacity of PC-3 prostate cancer cells and FTC-133 thyroid cancer cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O60701	-	-

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0000013	-	phycocyanobilin	substrate UDP-glucose, pH 8.5, 37°C	Homo sapiens
0.0000018	-	phycocyanobilin	substrate NAD+, pH 8.5, 37°C	Homo sapiens
0.00018	-	phycocyanin	substrate UDP-glucose, pH 8.5, 37°C	Homo sapiens
0.0009	-	phycocyanin	substrate NAD+, pH 8.5, 37°C	Homo sapiens

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Release 2023.1 (January 2023)