Ligand UDP-alpha-D-glucuronic acid

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Basic Ligand Information

Molecular Structure
Picture of UDP-alpha-D-glucuronic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C15H22N2O18P2
UDP-alpha-D-glucuronic acid
HDYANYHVCAPMJV-LXQIFKJMSA-N
Synonyms:
UDP-alpha-D-glucuronate, UDP-alpha-glucuronate, UDP-D-glucuronate, UDP-D-glucuronic acid, UDP-GlcA, UDP-GlcUA, UDP-glucuronate, UDP-glucuronic acid, UDPalpha-D-glucuronate, UDPglucuronate, UDPglucuronic acid


Show all pahtways known for Show all BRENDA pathways known for UDP-alpha-D-glucuronic acid

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (114 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N-acetyl-D-glucosaminyl-diphosphodolichol + UDP-glucuronic acid = D-glucuronyl-1,4-N-acetyl-D-glucosaminyl-diphosphodolichol + UDP
show the reaction diagram
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UDPglucuronic acid + luteolin = UDP + luteolin 7-O-glucuronide
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UDP-glucuronic acid + luteolin 7-O-beta-D-glucuronide = UDP + luteolin 7-O-[beta-D-glucuronosyl-(1->2)-beta-D-glucuronide]
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UDP-glucuronic acid + luteolin 7-O-[beta-D-glucuronosyl-(1->2)-beta-D-glucuronide] = UDP + luteolin 7-O-[beta-D-glucuronosyl-1,2-beta-D-glucuronide]-4'-O-beta-D-glucuronide
show the reaction diagram
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UDP-alpha-D-glucuronate + N-acetyl-alpha-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-proteoglycan = UDP + beta-glucuronosyl-(1-4)-N-acetyl-alpha-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-proteoglycan
show the reaction diagram
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UDP-alpha-D-glucuronate + an archaeal dolichyl beta-D-glucosyl phosphate = UDP + an archaeal dolichyl beta-D-glucuronosyl-(1->3)-beta-D-glucosyl phosphate
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UDP-glucuronate + a flavonol = UDP + a flavonol 3-O-beta-D-glucuronoside
show the reaction diagram
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UDP-glucuronic acid + H2O = UMP + glucuronic acid phosphate
show the reaction diagram
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UDP-D-glucuronate = UDP-D-xylose + CO2
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UDP-glucuronate = UDP-D-galacturonate
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (29 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
UTP + alpha-D-glucuronate 1-phosphate = diphosphate + UDP-D-glucuronate
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (698 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
UDP-alpha-D-glucuronate + NAD+ = UDP-alpha-D-ribo-hex-3-uluronate + NADH + H+
show the reaction diagram
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UDP-alpha-D-glucuronic acid + D-fructose = ?
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UDP-glucuronic acid + 4-methylumbelliferyl-beta-D-xylopyranoside = ?
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N-acetyl-D-glucosaminyl-diphosphodolichol + UDP-glucuronic acid = D-glucuronyl-1,4-N-acetyl-D-glucosaminyl-diphosphodolichol + UDP
show the reaction diagram
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UDP-alpha-D-glucuronic acid + a 1,2-diacyl-sn-glycerol = UDP + a 1,2-diacyl-3-O-(alpha-D-glucuronosyl)-sn-glycerol
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UDPglucuronic acid + p-nitrophenol = dTDP + p-nitrophenyl beta-D-glucuronic acid
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UDP-alpha-D-glucuronate + an archaeal dolichyl beta-D-glucosyl phosphate = UDP + an archaeal dolichyl beta-D-glucuronosyl-(1->3)-beta-D-glucosyl phosphate
show the reaction diagram
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UDP-glucuronic acid + 4-methylumbelliferyl beta-D-xylopyranoside = UDP + ?
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UDP-glucuronate + a flavonol = UDP + a flavonol 3-O-beta-D-glucuronoside
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UDP-glucuronic acid + H2O = UMP + glucuronic acid phosphate
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UDPglucuronate = UDP-L-iduronate
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Product in Enzyme-catalyzed Reactions (68 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
UTP + D-glucuronic acid 1-phosphate = diphosphate + UDP-D-glucuronic acid
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
30% increased XylT activity in microsomal fractions of stems from wild-type plants possibly due to increased solubility of xylooligomers
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Inhibitor in Enzyme-catalyzed Reactions (56 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
36% inhibition
-
1 mM, about 20% inhibition
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competitive, 76% inhibition
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most effective inhibitor, 0.025-0.050 mM, 50% inhibition
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0.5 mM, presence of 0.5 mM NAD+, 70% residual activity
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3D Structure of Enzyme-Ligand-Complex (PDB) (11 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (24 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.285
-
pH 7.6, 37°C, recombinant enzyme
-999
-
kcat value is above 0.2 1/min in 100 mM cacodylate buffer, pH 7.0 containing 10 mM MnCl2 and 0.2-6 microM purified fusion-beta1,4-GalT7
120
-
recombinant enzyme, pH 7.0, 30°C
0.003
-
Km above 0.003 mM, purified maltose-binding protein-beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C

KM Value (117 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
-999
-
KM value is above 4 in 100 mM cacodylate buffer, pH 7.0 containing 10 mM MnCl2 and 0.2-6 microM purified fusion-beta1,4-GalT7
0.012
-
-
0.04
-
-
0.09
-
-
0.0729
-
pH 7.5, 37°C
0.02394
-
using soyasapogenol B as the sugar acceptor, in 100 mM Tris-HCl (pH 8.0), at 40°C
4
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Km above 4 mM, purified maltose-binding protein-beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C
0.5
-
pH 8.0, 30°C

Ki Value (5 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.292
-
pH 8.4, 25°C
0.0076
-
-
0.55
-
pH 7.2, 30°C

References & Links