Reference on EC 6.1.1.10 - methionine-tRNA ligase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ogata, K.; Ohno, R.; Morioka, S.; Terao, K.
Further study on association of 5SrRNA-L5 protein complex and methionyl-tRNA to methionyl-tRNA synthetase in the macromolecular aminoacyl-tRNA synthetase complex
J. Biochem.
120
869-880
1996
Rattus norvegicus
Ogata, K.; Kurahashi, A.; Tanaka, S.; Ohsue, H.; Terao, K.
Occurence of 5SrRNA in high molecular weight complexes of aminoacyl-tRNA synthetases in a rat liver supernatant
J. Biochem.
110
1030-1036
1991
Rattus norvegicus
Ogata, K.; Kurahashi, A.; Kenmochi, N.; Terao, K.
Role of 5SrRNA as a positive effector of some aminoacyl-tRNA synthetases in macromolecular complexes, with specific reference to methionyl-tRNA synthetase
J. Biochem.
110
1037-1044
1991
Rattus norvegicus
Schmitt, E.; Panvert, M.; Blanquet, S.; Mechulam, Y.
Transition state stabilization by the `high' motif of class I aminoacyl-tRNA synthetases. The case of Escherichia coli methionyl-tRNA synthetase
Nucleic Acids Res.
23
4793-4798
1995
Escherichia coli
Meinnel, T.; Mechulam, Y.; Dardel, F.; Schmitter, J.M.; Hountondji, C.; Brunie, S.; Dessen, P.; Fayat, G.; Blanquet, S.
Methionyl-tRNA synthetase from E. coli - A review
Biochimie
72
625-632
1990
Escherichia coli
Fourmy, D.; Dardel, F.; Blanquet, S.
Methionyl-tRNA synthetase zinc binding domain
J. Mol. Biol.
231
1078-1089
1993
Escherichia coli
Brunie, S.; Zelwer, C.; Risler, J.L.
Crystallographic study at 2.5 A resolution of the interaction of methionyl-tRNA synthetase from Escherichia coli with ATP
J. Mol. Biol.
216
411-424
1990
Escherichia coli
Jakubowski, H.; Goldman, E.
Synthesis of homocysteine thiolactone by methionyl-tRNA synthetase in cultured mammalian cells
FEBS Lett.
317
237-240
1993
Saccharomyces cerevisiae, Cricetulus griseus, Escherichia coli, Homo sapiens, Mus musculus
Robert-Gero, M.; Waller, J.P.
Purification of methionyl-tRNA synthetase from Escherichia coli K12 by affinity chromatography
Eur. J. Biochem.
31
315-319
1972
Escherichia coli
Lawrence, F.
Effect of adenosine on methionyl-tRNA synthetase
Eur. J. Biochem.
40
493-500
1973
Escherichia coli
Koch, G.L.E.; Bruton, C.J.
The subunit structure of methionyl-tRNA synthetase from Escherichia coli
FEBS Lett.
40
180-182
1974
Escherichia coli, Escherichia coli EM
Posorske, L.H.; Cohn, M.; Yanagisawa, N.; Auld, D.S.
Methionyl-tRNA synthetase of Escherichia coli. A zinc metalloprotein
Biochim. Biophys. Acta
576
128-133
1979
Escherichia coli
Armstrong, J.B.; Fairfield, J.A.
A new method for the isolation of methionyl transfer synthetase mutants from Escherichia coli
Can. J. Microbiol.
21
754-758
1975
Escherichia coli
Chazal, Ph.; Thomes, J.C.; Julien, R.
Methionine-tRNA-ligase from wheat germ. Purification and properties
FEBS Lett.
56
268-272
1975
Triticum aestivum
Zelwer, C.; Risler, J.L.; Monteilhet, C.
A low-resolution model of crystalline methionyl-transfer RNA synthetase from Escherichia coli
J. Mol. Biol.
102
93-101
1976
Escherichia coli
Deobagkar, D.N.; Gopinathan, K.P.
Two forms of methionyl-tranfer RNA synthetase from Mycobacterium smegmatis
Biochem. Biophys. Res. Commun.
71
939-951
1976
Mycolicibacterium smegmatis
Burnell, J.N.; Whatley, F.R.
Sulphur metabolism in Paracoccus denitrificans. Purification, properties and regulation of cysteinyl- and methionyl-tRNA synthetase
Biochim. Biophys. Acta
481
266-278
1977
Paracoccus denitrificans, Paracoccus denitrificans 8944
Rosa, M.D.; Sigler, P.B.
Isolation and characterization of two methionine:tRNA ligases from wheat germ
Eur. J. Biochem.
78
141-151
1977
Triticum aestivum
Dickman, S.R.; Boll, D.J.
Differential purification of methionine-tRNA synthetase and lysine-tRNA synthetase from rabbit liver
Biochem. Biophys. Res. Commun.
78
1191-1197
1977
Rattus norvegicus
Kellermann, O.; Viel, C.; Waller, J.P.
Methionyl-tRNA synthetase from sheep mammary gland. Purification of a fully active monomeric enzyme derived from high-molecular-weight complexes by controlled proteolysis
Eur. J. Biochem.
88
197-204
1978
Ovis aries
Kellermann, O.; Brevet, A.; Tonetti, H.; Waller, J.P.
Methionyl-tRNA synthetase from sheep liver. Purification of a fully active monomer derived from high-molecular-weight complexes by trypsin treatment
Eur. J. Biochem.
88
205-210
1978
Ovis aries
Joachimiak, A.; Barciszewski, J.; Twardowski, T.; Barciszewska, M.; Wiewiorowski, M.
Purification and properties of methionyl-tRNA synthetase from yellow lupine seeds
FEBS Lett.
93
51-54
1978
Lupinus sp.
-
Burnell, J.N.
Methionyl-tRNA synthetase from Phaseolus aureus. Purification and properties
Plant Physiol.
67
325-329
1981
Vigna radiata var. radiata
Carias, J.R.; Mouricout, M.; Julien, R.
Chloroplastic methionyl-tRNA synthetase from wheat
Biochem. Biophys. Res. Commun.
98
735-742
1981
Triticum aestivum
Zelwer, C.; Risler, J.L.; Brunie, S.
Crystal structure of Escherichia coli methionyl-tRNA synthetase at 2.5 A resolution
J. Mol. Biol.
155
63-81
1982
Escherichia coli
Kohda, D.; Yokoyama, S; Miyazawa, T.
Thermostable valyl-tRNA, isoleucyl-tRNA and methionyl-tRNA synthetases from an extreme thermophile Thermus thermophilus HB8. Protein structure and Zn2+ binding
FEBS Lett.
174
20-23
1984
Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579
Kohda, D.; Yokoyama, S.; Miyazawa, T.
Functions of isolated domains of methionyl-tRNA synthetase from an extreme thermophile, Thermus thermophilus HB8
J. Biol. Chem.
262
558-563
1987
Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579
Dardel, F.; Fayat, G.; Blanqauet, S.
Molecular cloning and primary structure of the Escherichia coli methionyl-tRNA synthetase gene
J. Bacteriol.
160
1115-1122
1984
Escherichia coli
Fasiolo,F.; Gibson, B.W.; Walter, P.; Chatton, B.; Biemann, K.; Boulanger, Y.
Cytoplasmic methionyl-tRNA synthetase from bakers' yeast. A monomer with a post-translationally modified N-terminus
J. Biol. Chem.
260
15571-15576
1985
Saccharomyces cerevisiae
Deniziak, M.A.; Barciszewski, J.
Methionyl-tRNA synthetase
Acta Biochim. Pol.
48
337-350
2001
Escherichia coli, Thermus thermophilus
Kaminska, M.; Shalak, V.; Mirande, M.
The appended C-domain of human methionyl-tRNA synthetase has a tRNA-sequestering function
Biochemistry
40
14309-14316
2001
Homo sapiens
Crepin, T.; Schmitt, E.; Blanquet, S.; Mechulam, Y.
Structure and function of the C-terminal domain of methionyl-tRNA synthetase
Biochemistry
41
13003-13011
2002
Escherichia coli, Pyrococcus abyssi (Q9V011), Pyrococcus abyssi
Lee, J.; Kang, S.U.; Kim, S.Y.; Kim, S.E.; Kang, M.K.; Jo, Y.J.; Kim, S.
Ester and hydroxamate analogues of methionyl and isoleucyl adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases
Bioorg. Med. Chem. Lett.
11
961-964
2001
Escherichia coli
Lee, J.; Kang, S.U.; Kim, S.Y.; Kim, S.E.; Job, Y.J.; Kim, S.
Vanilloid and isovanilloid analogues as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases
Bioorg. Med. Chem. Lett.
11
965-968
2001
Escherichia coli
Kaminska, M.; Deniziak, M.; Kerjan, P.; Barciszewski, J.; Mirande, M.
A recurrent general RNA binding domain appended to plant methionyl-tRNA synthetase acts as a cis-acting cofactor for aminoacylation
EMBO J.
19
6908-6917
2000
Oryza sativa (Q9ZTS1), Oryza sativa
Kim, S.; Jo, Y.J.; Lee, S.H.; Motegi, H.; Shiba, K.; Sassanfar, M.; Martinis, S.A.
Biochemical and phylogenetic analyses of methionyl-tRNA synthetase isolated from a pathogenic microorganism, Mycobacterium tuberculosis
FEBS Lett.
427
259-262
1998
Escherichia coli, Mycobacterium tuberculosis
Lee, S.W.; Jo, Y.J.; Kim, S.
Cloning and characterization of mitochondrial methionyl-tRNA synthetase from a pathogenic fungi Candida albicans
Gene
215
311-318
1998
Candida albicans (O74634), Candida albicans
Jo, Y.J.; Lee, S.W.; Jo, M.K.; Lee, J.W.; Kang, M.K.; Yoon, J.H.; Kim, S.
Methionine analogue probes functionally important residues in active site of methionyl-tRNA synthetase
J. Biochem. Mol. Biol.
32
547-553
1999
Escherichia coli
-
Ramesh, V.; RajBhandary, U.L.
Importance of the anticodon sequence in the aminoacylation of tRNAs by methionyl-tRNA synthetase and by valyl-tRNA synthetase in an archaebacterium
J. Biol. Chem.
276
3660-3665
2001
Haloferax volcanii, Haloferax volcanii WFD11
Ko, Y.G.; Kang, Y.S.; Kim, E.K.; Park, S.G.; Kim, S.
Nucleolar localization of human methionyl-tRNA synthetase and its role in ribosomal RNA synthesis
J. Cell Biol.
149
567-574
2000
Homo sapiens
Mechulam, Y.; Schmitt, E.; Maveyraud, L.; Zelwer, C.; Nureki, O.; Yokoyama, S.; Konno, M.; Blanquet, S.
Crystal structure of Escherichia coli methionyl-tRNA synthetase highlights species-specific features
J. Mol. Biol.
294
1287-1297
1999
Escherichia coli
Serre, L.; Verdon, G.; Choinowski, T.; Hervouet, N.; Risler, J.L.; Zelwer, C.
How methionyl-tRNA synthetase creates its amino acid recognition pocket upon L-methionine binding
J. Mol. Biol.
306
863-876
2001
Escherichia coli
Senger, B.; Despons, L.; Walter, P.; Jakubowski, H.; Fasiolo, F.
Yeast cytoplasmic and mitochondrial methionyl-tRNA synthetases: two structural frameworks for identical functions
J. Mol. Biol.
311
205-216
2001
Saccharomyces cerevisiae
Crepin, T.; Schmitt, E.; Mechulam, Y.; Sampson, P.B.; Vaughan, M.D.; Honek, J.F.; Blanquet, S.
Use of analogues of methionine and methionyl adenylate to sample conformational changes during catalysis in Escherichia coli methionyl-tRNA synthetase
J. Mol. Biol.
332
59-72
2003
Escherichia coli (P00959), Escherichia coli
Hountondji, C.; Beauvallet, C.; Pernollet, J.C.; Blanquet, S.
Enzyme-induced covalent modification of methionyl-tRNA synthetase from Bacillus stearothermophilus by methionyl-adenylate: identification of the labeled amino acid residues by matrix-assisted laser desorption-ionization mass spectrometry
J. Protein Chem.
19
563-568
2000
Geobacillus stearothermophilus
Menand, B.; Marechal-Drouard, L.; Sakamoto, W.; Dietrich, A.; Wintz, H.
A single gene of chloroplast origin codes for mitochondrial and chloroplastic methionyl-tRNA synthetase in Arabidopsis thaliana
Proc. Natl. Acad. Sci. USA
95
11014-11019
1998
Arabidopsis thaliana, Arabidopsis thaliana (O23761), Arabidopsis thaliana (Q9M2T9), Pisum sativum
Sugiura, I.; Nureki, O.; Ugaji-Yoshikawa, Y.; Kuwabara, S.; Shimada, A.; Tateno, M.; Lorber, B.; Giege, R.; Moras, D.; Yokoyama, S.; Konno, M.
The 2.0 A crystal structure of Thermus thermophilus methionyl-tRNA synthetase reveals two RNA-binding modules
Structure
8
197-208
2000
Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579
Kiick, K.L.; Tirrell, D.A.
Protein Engineering by In Vivo Incorporation of Non-Natural Amino Acids: Control of Incorporation of Methionine Analogues by Methionyl-tRNA Synthetase
Tetrahedron
56
9487-9493
2000
Escherichia coli (P00959)
-
Crepin, T.; Schmitt, E.; Blanquet, S.; Mechulam, Y.
Three-dimensional structure of methionyl-tRNA synthetase from Pyrococcus abyssi
Biochemistry
43
2635-2644
2004
Pyrococcus abyssi (Q9V011), Pyrococcus abyssi
Spencer, A.C.; Heck, A.; Takeuchi, N.; Watanabe, K.; Spremulli, L.L.
Characterization of the human mitochondrial methionyl-tRNA synthetase
Biochemistry
43
9743-9754
2004
Homo sapiens (P56192), Homo sapiens
Tandon, M.; Coffen, D.L.; Gallant, P.; Keith, D.; Ashwell, M.A.
Potent and selective inhibitors of bacterial methionyl tRNA synthetase derived from an oxazolone-dipeptide scaffold
Bioorg. Med. Chem. Lett.
14
1909-1911
2004
Enterococcus faecalis, Staphylococcus aureus
Jarvest, R.L.; Armstrong, S.A.; Berge, J.M.; Brown, P.; Elder, J.S.; Brown, M.J.; Copley, R.C.; Forrest, A.K.; Hamprecht, D.W.; O'Hanlon, P.J.; Mitchell, D.J.; Rittenhouse, S.; Witty, D.R.
Definition of the heterocyclic pharmacophore of bacterial methionyl tRNA synthetase inhibitors: potent antibacterially active non-quinolone analogues
Bioorg. Med. Chem. Lett.
14
3937-3941
2004
Enterococcus faecalis, Enterococcus faecium, Staphylococcus aureus, Staphylococcus epidermidis
Nakanishi, K.; Ogiso, Y.; Nakama, T.; Fukai, S.; Nureki, O.
Structural basis for anticodon recognition by methionyl-tRNA synthetase
Nat. Struct. Mol. Biol.
12
931-932
2005
Aquifex aeolicus
Yoo, T.H.; Tirrell, D.A.
High-throughput screening for methionyl-tRNA synthetases that enable residue-specific incorporation of noncanonical amino acids into recombinant proteins in bacterial cells
Angew. Chem.
46
5340-5343
2007
Escherichia coli
Kedar, G.C.; Brown-Driver, V.; Reyes, D.R.; Hilgers, M.T.; Stidham, M.A.; Shaw, K.J.; Finn, J.; Haselbeck, R.J.
Evaluation of the metS and murB loci for antibiotic discovery using targeted antisense RNA expression analysis in Bacillus anthracis
Antimicrob. Agents Chemother.
51
1708-1718
2007
Bacillus anthracis
Farhanullah, R.J.; Kim, S.Y.; Yoon, E.J.; Choi, E.C.; Kim, S.; Kang, T.; Samrin, F.; Puri, S.; Lee, J.
Design and synthesis of quinolinones as methionyl-tRNA synthetase inhibitors
Bioorg. Med. Chem.
14
7154-7159
2006
Staphylococcus aureus
Kim, S.Y.; Lee, Y.S.; Kang, T.; Kim, S.; Lee, J.
Pharmacophore-based virtual screening: the discovery of novel methionyl-tRNA synthetase inhibitors
Bioorg. Med. Chem. Lett.
16
4898-4907
2006
Escherichia coli
Bharatham, N.; Bharatham, K.; Lee, K.W.
Pharmacophore identification and virtual screening for methionyl-tRNA synthetase inhibitors
J. Mol. Graph. Model.
25
813-823
2007
Staphylococcus aureus
Abergel, C.; Rudinger-Thirion, J.; Giege, R.; Claverie, J.M.
Virus-encoded aminoacyl-tRNA synthetases: structural and functional characterization of mimivirus TyrRS and MetRS
J. Virol.
81
12406-12417
2007
Acanthamoeba polyphaga Mimivirus
Simader, H.; Hothorn, M.; Koehler, C.; Basquin, J.; Simos, G.; Suck, D.
Structural basis of yeast aminoacyl-tRNA synthetase complex formation revealed by crystal structures of two binary sub-complexes
Nucleic Acids Res.
34
3968-3979
2006
Saccharomyces cerevisiae (P00958), Saccharomyces cerevisiae
Link, A.J.; Vink, M.K.; Agard, N.J.; Prescher, J.A.; Bertozzi, C.R.; Tirrell, D.A.
Discovery of aminoacyl-tRNA synthetase activity through cell-surface display of noncanonical amino acids
Proc. Natl. Acad. Sci. USA
103
10180-10185
2006
Escherichia coli (P00959), Escherichia coli
Ghosh, A.; Vishveshwara, S.
A study of communication pathways in methionyl-tRNA synthetase by molecular dynamics simulations and structure network analysis
Proc. Natl. Acad. Sci. USA
104
15711-15716
2007
Escherichia coli
Farhanullah, ; Kang, T.; Yoon, E.J.; Choi, E.C.; Kim, S.; Lee, J.
2-[2-Substituted-3-(3,4-dichlorobenzylamino)propylamino]-1H-quinolin-4-ones as Staphylococcus aureus methionyl-tRNA synthetase inhibitors
Eur. J. Med. Chem.
44
239-250
2008
Staphylococcus aureus
Ingvarsson, H.; Jones, T.A.; Unge, T.
Crystallization of Mycobacterium smegmatis methionyl-tRNA synthetase in the presence of methionine and adenosine
Acta Crystallogr. Sect. F
65
618-620
2009
Mycolicibacterium smegmatis (A0R3E2), Mycolicibacterium smegmatis
Green, L.; Bullard, J.; Ribble, W.; Dean, F.; Ayers, D.; Ochsner, U.; Janjic, N.; Jarvis, T.
Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity
Antimicrob. Agents Chemother.
53
86-94
2009
Escherichia coli, Haemophilus influenzae, Homo sapiens, Staphylococcus aureus, Streptococcus pneumoniae
Critchley, I.A.; Green, L.S.; Young, C.L.; Bullard, J.M.; Evans, R.J.; Price, M.; Jarvis, T.C.; Guiles, J.W.; Janjic, N.; Ochsner, U.A.
Spectrum of activity and mode of action of REP3123, a new antibiotic to treat Clostridium difficile infections
J. Antimicrob. Chemother.
63
954-963
2009
Clostridioides difficile, Streptococcus pneumoniae, Escherichia coli, Haemophilus influenzae, Homo sapiens, Staphylococcus aureus
Ochsner, U.A.; Bell, S.J.; OLeary, A.L.; Hoang, T.; Stone, K.C.; Young, C.L.; Critchley, I.A.; Janjic, N.
Inhibitory effect of REP3123 on toxin and spore formation in Clostridium difficile, and in vivo efficacy in a hamster gastrointestinal infection model
J. Antimicrob. Chemother.
63
964-971
2009
Clostridioides difficile
Schmitt, E.; Tanrikulu, I.C.; Yoo, T.H.; Panvert, M.; Tirrell, D.A.; Mechulam, Y.
Switching from an induced-fit to a lock-and-key mechanism in an aminoacyl-tRNA synthetase with modified specificity
J. Mol. Biol.
394
843-851
2009
Escherichia coli (P00959)
Shibata, S.; Gillespie, J.R.; Kelley, A.M.; Napuli, A.J.; Zhang, Z.; Kovzun, K.V.; Pefley, R.M.; Lam, J.; Zucker, F.H.; Van Voorhis, W.C.; Merritt, E.A.; Hol, W.G.; Verlinde, C.L.; Fan, E.; Buckner, F.S.
Selective inhibitors of methionyl-tRNA synthetase have potent activity against Trypanosoma brucei infection in mice
Antimicrob. Agents Chemother.
55
1982-1989
2011
Trypanosoma brucei
Casina, V.C.; Lobashevsky, A.A.; McKinney, W.E.; Brown, C.L.; Alexander, R.W.
Role for a conserved structural motif in assembly of a class I aminoacyl-tRNA synthetase active site
Biochemistry
50
763-769
2011
Escherichia coli
Larson, E.T.; Kim, J.E.; Zucker, F.H.; Kelley, A.; Mueller, N.; Napuli, A.J.; Verlinde, C.L.; Fan, E.; Buckner, F.S.; Van Voorhis, W.C.; Merritt, E.A.; Hol, W.G.
Structure of Leishmania major methionyl-tRNA synthetase in complex with intermediate products methionyladenylate and pyrophosphate
Biochimie
93
570-582
2011
Leishmania major
Ingvarsson, H.; Unge, T.
Flexibility and communication within the structure of the Mycobacterium smegmatis methionyl-tRNA synthetase
FEBS J.
277
3947-3962
2010
Mycolicibacterium smegmatis
Al-Moubarak, E.; Simons, C.
A homology model for Clostridium difficile methionyl tRNA synthetase: active site analysis and docking interactions
J. Mol. Model.
17
1679-1693
2010
Clostridioides difficile (Q181D9), Clostridioides difficile, Clostridioides difficile 630 (Q181D9)
Havrylenko, S.; Legouis, R.; Negrutskii, B.; Mirande, M.
Methionyl-tRNA synthetase from Caenorhabditis elegans: a specific multidomain organization for convergent functional evolution
Protein Sci.
19
2475-2484
2010
Caenorhabditis elegans
Kang, T.; Kim, G.; Park, S.G.; Jo, Y.J.
Convergent evolution of two different random RNAs for specific interaction with methionyl-tRNA synthetase
Biochem. Biophys. Res. Commun.
432
281-286
2013
Mycobacterium tuberculosis
van Meel, E.; Wegner, D.J.; Cliften, P.; Willing, M.C.; White, F.V.; Kornfeld, S.; Cole, F.S.
Rare recessive loss-of-function methionyl-tRNA synthetase mutations presenting as a multi-organ phenotype
BMC Med. Genet.
14
106
2013
Homo sapiens (P56192)
Kwon, N.H.; Kang, T.; Lee, J.Y.; Kim, H.H.; Kim, H.R.; Hong, J.; Oh, Y.S.; Han, J.M.; Ku, M.J.; Lee, S.Y.; Kim, S.
Dual role of methionyl-tRNA synthetase in the regulation of translation and tumor suppressor activity of aminoacyl-tRNA synthetase-interacting multifunctional protein-3
Proc. Natl. Acad. Sci. USA
108
19635-19640
2011
Homo sapiens
Jones, T.E.; Alexander, R.W.; Pan, T.
Misacylation of specific nonmethionyl tRNAs by a bacterial methionyl-tRNA synthetase
Proc. Natl. Acad. Sci. USA
108
6933-6938
2011
Escherichia coli (P00959), Escherichia coli
Ngo, J.T.; Schuman, E.M.; Tirrell, D.A.
Mutant methionyl-tRNA synthetase from bacteria enables site-selective N-terminal labeling of proteins expressed in mammalian cells
Proc. Natl. Acad. Sci. USA
110
4992-4997
2013
Escherichia coli
Koh, C.Y.; Kim, J.E.; Shibata, S.; Ranade, R.M.; Yu, M.; Liu, J.; Gillespie, J.R.; Buckner, F.S.; Verlinde, C.L.; Fan, E.; Hol, W.G.
Distinct states of methionyl-tRNA synthetase indicate inhibitor binding by conformational selection
Structure
20
1681-1691
2012
Trypanosoma brucei (Q38C91), Trypanosoma brucei
Torrie, L.S.; Brand, S.; Robinson, D.A.; Ko, E.J.; Stojanovski, L.; Simeons, F.R.C.; Wyllie, S.; Thomas, J.; Ellis, L.; Osuna-Cabello, M.; Epemolu, O.; Nuehs, A.; Riley, J.; MacLean, L.; Manthri, S.; Read, K.D.; Gilbert, I.H.; Fairlamb, A.H.; De Rycker, M.
Chemical validation of methionyl-tRNA synthetase as a druggable target in Leishmania donovani
ACS Infect. Dis.
3
718-727
2017
Leishmania donovani
Hussain, T.; Yogavel, M.; Sharma, A.
Inhibition of protein synthesis and malaria parasite development by drug targeting of methionyl-tRNA synthetases
Antimicrob. Agents Chemother.
59
1856-1867
2015
Plasmodium falciparum
Fortowsky, G.B.; Simard, D.J.; Aboelnga, M.M.; Gauld, J.W.
Substrate-assisted and enzymatic pretransfer editing of nonstandard amino acids by methionyl-tRNA synthetase
Biochemistry
54
5757-5765
2015
Pyrococcus abyssi (Q9V011)
Kim, E.Y.; Jung, J.Y.; Kim, A.; Kim, K.; Chang, Y.S.
Methionyl-tRNA synthetase overexpression is associated with poor clinical outcomes in non-small cell lung cancer
BMC Cancer
17
467
2017
Homo sapiens, Mus musculus
Huang, W.; Zhang, Z.; Barros-Alvarez, X.; Koh, C.Y.; Ranade, R.M.; Gillespie, J.R.; Creason, S.A.; Shibata, S.; Verlinde, C.L.M.J.; Hol, W.G.J.; Buckner, F.S.; Fan, E.
Structure-guided design of novel Trypanosoma brucei methionyl-tRNA synthetase inhibitors
Eur. J. Med. Chem.
124
1081-1092
2016
Trypanosoma brucei (Q38C91), Trypanosoma brucei, Trypanosoma brucei 927 (Q38C91)
Yi, H.; Lee, H.; Cho, K.H.; Kim, H.S.
Mutations in MetG (methionyl-tRNA synthetase) and TrmD [tRNA (guanine-N1)-methyltransferase] conferring meropenem tolerance in Burkholderia thailandensis
J. Antimicrob. Chemother.
73
332-338
2018
Burkholderia thailandensis (Q2T087), Burkholderia thailandensis
Lee, J.Y.; Kim, D.G.; Kim, B.G.; Yang, W.S.; Hong, J.; Kang, T.; Oh, Y.S.; Kim, K.R.; Han, B.W.; Hwang, B.J.; Kang, B.S.; Kang, M.S.; Kim, M.H.; Kwon, N.H.; Kim, S.
Promiscuous methionyl-tRNA synthetase mediates adaptive mistranslation to protect cells against oxidative stress
J. Cell Sci.
127
4234-4245
2014
Escherichia coli
Eissa, A.G.; Blaxland, J.A.; Williams, R.O.; Metwally, K.A.; El-Adl, S.M.; Lashine, E.L.-S.M.; Baillie, L.W.; Simons, C.
Targeting methionyl tRNA synthetase design, synthesis and antibacterial activity against Clostridium difficile of novel 3-biaryl-N-benzylpropan-1-amine derivatives
J. Enzyme Inhib. Med. Chem.
31
1694-1697
2016
Clostridioides difficile, Clostridioides difficile 1813
Suzuki, H.; Kaneko, A.; Yamamoto, T.; Nambo, M.; Hirasawa, I.; Umehara, T.; Yoshida, H.; Park, S.Y.; Tamura, K.
Binding properties of split tRNA to the C-terminal domain of methionyl-tRNA synthetase of Nanoarchaeum equitans
J. Mol. Evol.
84
267-278
2017
Nanoarchaeum equitans (Q74MZ1), Nanoarchaeum equitans
Alriyami, M.Z.; Jones, M.R.; Johnsen, R.C.; Banerjee, Y.; Baillie, D.L.
Let-65 is cytoplasmic methionyl tRNA synthetase in C. elegans
Meta Gene
2
819-830
2014
Caenorhabditis elegans, Caenorhabditis elegans N2 Bristol
Bharathkumar, H.; Mohan, C.D.; Rangappa, S.; Kang, T.; Keerthy, H.K.; Fuchs, J.E.; Kwon, N.H.; Bender, A.; Kim, S.; Basappa, S.; Rangappa, K.S.
Screening of quinoline, 1,3-benzoxazine, and 1,3-oxazine-based small molecules against isolated methionyl-tRNA synthetase and A549 and HCT116 cancer cells including an in silico binding mode analysis
Org. Biomol. Chem.
13
9381-9387
2015
Homo sapiens
Koh, C.Y.; Kim, J.E.; Wetzel, A.B.; de van der Schueren, W.J.; Shibata, S.; Ranade, R.M.; Liu, J.; Zhang, Z.; Gillespie, J.R.; Buckner, F.S.; Verlinde, C.L.; Fan, E.; Hol, W.G.
Structures of Trypanosoma brucei methionyl-tRNA synthetase with urea-based inhibitors provide guidance for drug design against sleeping sickness
PLoS Negl. Trop. Dis.
8
e2775
2014
Trypanosoma brucei (Q38C91), Trypanosoma brucei, Trypanosoma brucei 927 (Q38C91)
Ojo, K.K.; Ranade, R.M.; Zhang, Z.; Dranow, D.M.; Myers, J.B.; Choi, R.; Nakazawa Hewitt, S.; Edwards, T.E.; Davies, D.R.; Lorimer, D.; Boyle, S.M.; Barrett, L.K.; Buckner, F.S.; Fan, E.; Van Voorhis, W.C.
Brucella melitensis methionyl-tRNA-synthetase (MetRS), a potential drug target for brucellosis
PLoS ONE
11
e0160350
2016
Brucella melitensis (Q2YQ76), Brucella melitensis, Brucella melitensis 2308 (Q2YQ76)
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