Literature summary for 6.1.1.10 extracted from

Farhanullah, ; Kang, T.; Yoon, E.J.; Choi, E.C.; Kim, S.; Lee, J.
2-[2-Substituted-3-(3,4-dichlorobenzylamino)propylamino]-1H-quinolin-4-ones as Staphylococcus aureus methionyl-tRNA synthetase inhibitors (2008), Eur. J. Med. Chem., 44, 239-250.

Search for more literature for 6.1.1.10

Inhibitors

Inhibitors	Comment	Organism	Structure
2-[2-allyloxy-3-(3,4-dichlorobenzylamino)-propylamino]-1H-quinolin-4-one	-	Staphylococcus aureus
2-[2-amino-3-(3,4-dichlorobenzylamino)-propylamino]-1H-quinolin-4-one tri(trifluoroacetic acid)	-	Staphylococcus aureus
2-[2-benzyloxy-3-(3,4-dichlorobenzylamino)-propylamino]-1H-quinolin-4-one	-	Staphylococcus aureus
2-[3-(3,4-dichlorobenzylamino)-2-dimethylaminopropylamino]-1H-quinolin-4-one	-	Staphylococcus aureus
2-[3-(3,4-dichlorobenzylamino)-2-ethoxypropylamino]-1H-quinolin-4-one	-	Staphylococcus aureus
2-[3-(3,4-dichlorobenzylamino)-2-hydroxymethylpropylamino]-1H-quinolin-4-one	-	Staphylococcus aureus
2-[3-(3,4-dichlorobenzylamino)-2-isopropoxy-propylamino]-1H-quinolin-4-one	-	Staphylococcus aureus
2-[3-(3,4-dichlorobenzylamino)-2-methoxymethylpropylamino]-1H-quinolin-4-one	-	Staphylococcus aureus
2-[3-(3,4-dichlorobenzylamino)-2-propylamino]-1H-quinolin-4-one	-	Staphylococcus aureus
2-[3-[bis-(3,4-dichlorobenzyl)-amino]-2-dimethylamino-propylamino]-1H-quinolin-4-one	-	Staphylococcus aureus
benzoic acid 1-[(3,4-dichlorobenzylamino)-methyl]-2-(4-oxo-1,4-dihydroquinolin-2-ylamino)-ethyl ester	-	Staphylococcus aureus
[1-[(3,4-dichlorobenzylamino)-methyl]-2-(4-oxo-1,4-dihydroquinolin-2-ylamino)ethyl]-carbamic acid tert-butyl ester	-	Staphylococcus aureus

Organism

Organism	UniProt	Comment	Textmining
Staphylococcus aureus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + L-methionine + tRNAMet	-	Staphylococcus aureus	AMP + diphosphate + L-methionyl-tRNAMet	-	?

Synonyms

Synonyms	Comment	Organism
methionyl-tRNA synthetase	-	Staphylococcus aureus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0000034	-	-	Staphylococcus aureus	2-[3-(3,4-dichlorobenzylamino)-2-propylamino]-1H-quinolin-4-one
0.0000119	-	-	Staphylococcus aureus	2-[3-(3,4-dichlorobenzylamino)-2-hydroxymethylpropylamino]-1H-quinolin-4-one
0.000015	-	-	Staphylococcus aureus	2-[3-(3,4-dichlorobenzylamino)-2-methoxymethylpropylamino]-1H-quinolin-4-one
0.0000247	-	-	Staphylococcus aureus	2-[2-benzyloxy-3-(3,4-dichlorobenzylamino)-propylamino]-1H-quinolin-4-one
0.0000294	-	-	Staphylococcus aureus	2-[2-allyloxy-3-(3,4-dichlorobenzylamino)-propylamino]-1H-quinolin-4-one
0.0000303	-	-	Staphylococcus aureus	2-[3-(3,4-dichlorobenzylamino)-2-ethoxypropylamino]-1H-quinolin-4-one
0.0000396	-	-	Staphylococcus aureus	2-[3-(3,4-dichlorobenzylamino)-2-dimethylaminopropylamino]-1H-quinolin-4-one
0.0000694	-	-	Staphylococcus aureus	benzoic acid 1-[(3,4-dichlorobenzylamino)-methyl]-2-(4-oxo-1,4-dihydroquinolin-2-ylamino)-ethyl ester
0.000091	-	-	Staphylococcus aureus	2-[3-(3,4-dichlorobenzylamino)-2-isopropoxy-propylamino]-1H-quinolin-4-one
0.000102	-	-	Staphylococcus aureus	[1-[(3,4-dichlorobenzylamino)-methyl]-2-(4-oxo-1,4-dihydroquinolin-2-ylamino)ethyl]-carbamic acid tert-butyl ester
0.000102	-	-	Staphylococcus aureus	2-[2-amino-3-(3,4-dichlorobenzylamino)-propylamino]-1H-quinolin-4-one tri(trifluoroacetic acid)
0.000131	-	-	Staphylococcus aureus	2-[3-[bis-(3,4-dichlorobenzyl)-amino]-2-dimethylamino-propylamino]-1H-quinolin-4-one

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Release 2023.1 (January 2023)