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Literature summary for 6.1.1.10 extracted from

  • Bharatham, N.; Bharatham, K.; Lee, K.W.
    Pharmacophore identification and virtual screening for methionyl-tRNA synthetase inhibitors (2007), J. Mol. Graph. Model., 25, 813-823.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information inhibitor screening, hstructures, omology modeling, molecular docking studies, and computational development of pharmacophore models, overview; inhibitor screening, structures, homology modeling, molecular docking studies, and computational development of pharmacophore models, overview Staphylococcus aureus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Staphylococcus aureus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-methionine + tRNAMet Staphylococcus aureus
-
AMP + diphosphate + L-methionyl-tRNAMet
-
?

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-methionine + tRNAMet
-
Staphylococcus aureus AMP + diphosphate + L-methionyl-tRNAMet
-
?

Subunits

Subunits Comment Organism
More three-dimensional structure of MetRS by homology modeling method, overview Staphylococcus aureus

Synonyms

Synonyms Comment Organism
methionyl-tRNA synthetase
-
Staphylococcus aureus
MetRS
-
Staphylococcus aureus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Staphylococcus aureus