Reference on EC 3.8.1.5 - haloalkane dehalogenase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Keuning, S.; Janssen, D.B.; Witholt, B.
Purification and characterization of hydrolytic haloalkane dehalogenase from Xanthobacter autotrophicus GJ10
J. Bacteriol.
163
635-639
1985
Xanthobacter autotrophicus, Xanthobacter autotrophicus GJ10
Yokota, T.; Omori, T.; Kodama, T.
Purification and properties of haloalkane dehalogenase from Corynebacterium sp. strain m15-3
J. Bacteriol.
169
4049-4054
1987
Corynebacterium sp., Corynebacterium sp. m15-3
Scholtz, R.; Leisinger, T.; Suter, F.; Cook, A.M.
Characterization of 1-chlorohexane halidohydrolase, a dehalogenase of wide substrate range from an Arthrobacter sp
J. Bacteriol.
169
5016-5021
1987
Arthrobacter sp., Arthrobacter sp. HA1
Franken, S.M.; Rozeboom, H.J.; Kalk, K.H.; Dijkstra, B.W.
Crystal structure of haloalkane dehalogenase: an enzyme to detoxify halogenated alkanes
EMBO J.
10
1297-1302
1991
Xanthobacter autotrophicus, Xanthobacter autotrophicus GJ10
Verschueren, K.H.G.; Franken, S.M.; Rozeboom, H.J.; Kalk, K.H.; Dijkstra, B.W.
Non-covalent binding of the heavy atom compound [Au(CN)2]- at the halide binding site of haloalkane dehalogenase from Xanthobacter autotrophicus GJ10
FEBS Lett.
323
267-270
1993
Xanthobacter autotrophicus, Xanthobacter autotrophicus GJ10
Verschueren, K.H.G.; Franken, S.M.; Rozeboom, H.J.; Kalk, K.H.; Dijkstra, B.W.
Refined X-ray structures of haloalkane dehalogenase at pH 6.2 and pH 8.2 and implications for the reaction mechanism
J. Mol. Biol.
232
856-872
1993
Xanthobacter autotrophicus, Xanthobacter autotrophicus GJ10
Verschueren, K.H.G.; Seljee, F.; Rozeboom, H.J.; Kalk, K.H.; Dijkstra, B.W.
Crystallographic analysis of the catalytic mechanism of haloalkane dehalogenase
Nature
363
693-698
1993
Xanthobacter autotrophicus, Xanthobacter autotrophicus GJ10
Prince, R.C.
Haloalkane dehalogenase caught in the act
Trends Biochem. Sci.
19
3-4
1994
Xanthobacter autotrophicus, Rhodococcus sp., Xanthobacter autotrophicus GJ10
Kennes, C.; Pries, F.; Krooshof, G.H.; Bokma, E.; Kingma, J.; Janssen, D.B.
Replacement of tryptophan residues in haloalkane dehalogenase reduces halide binding and catalytic activity
Eur. J. Biochem.
228
403-407
1995
Escherichia coli
Rozeboom, H.J.; Kingma, J.; Janssen, D.B.; Dijkstra, B.W.
Crystallization of haloalkane dehalogenase from Xanthobacter autotrophicus GJ10
J. Mol. Biol.
200
611-612
1988
Xanthobacter autotrophicus, Xanthobacter autotrophicus GJ10
Sallis, P.J.; Armfield, S.J.; Bull, A.T.; Hardman, D.J.
Isolation and characterization of a haloalkane halidohydrolase from Rhodococcus erythropolis Y2
J. Gen. Microbiol.
136
115-120
1990
Rhodococcus erythropolis, Rhodococcus erythropolis Y2
Schanstra, J.P.; Ridder, I.S.; Heimeriks, G.J.; Rink, R.; Poelarends, G.J.; Kalk, K.H.; Dijkstra, B.W.; Janssen, D.B.
Kinetic characterization and X-ray structure of a mutant of haloalkane dehalogenase with higher catalytic activity and modified substrate range
Biochemistry
35
13185-13195
1996
Xanthobacter autotrophicus, Xanthobacter autotrophicus GJ10
-
Damborsky, J.; Nyandoroh, M.G.; Nemec, M.; Holoubek, I.; Bull, A.T.; Hardman, D.J.
Some biochemical properties and the classification of a range of bacterial haloalkane dehalogenases
Biotechnol. Appl. Biochem.
26
19-25
1997
Arthrobacter sp., Xanthobacter autotrophicus, Corynebacterium sp., Pseudomonas sp., Rhodococcus erythropolis, Rhodococcus erythropolis Y2, Arthrobacter sp. HA1, Rhodococcus erythropolis CP9, Pseudomonas sp. E4M
Nagata, Y.; Hynkova, K.; Damborsky, J.; Takagi, M.
Construction and characterization of histidine-tagged haloalkane dehalogenase (LinB) of a new substrate class from a gamma-hexachlorocyclohexane-degrading bacterium, Sphingomonas paucimobilis UT26
Protein Expr. Purif.
17
299-304
1999
Sphingomonas paucimobilis, Sphingomonas paucimobilis UT26
Nagata, Y.; Miyauchi, K.; Damborsky, J.; Manova, K.; Ansorgova, A.; Takagi, M.
Purification and characterization of a haloalkane dehalogenase of a new substrate class from a gamma-hexachlorocyclohexane-degrading bacterium, Sphingomonas paucimobilis UT26
Appl. Environ. Microbiol.
63
3707-3710
1997
Sphingomonas paucimobilis, Sphingomonas paucimobilis UT26
Pries, F.; Kingma, J.; Krooshof, G.H.; Jeronimus-Stratingh, C.M.; Bruins, A.; Janssen, D.B.
Histidine 289 is essential for hydrolysis of the alkyl-enzyme intermediate of haloalkane dehalogenase
J. Biol. Chem.
270
10405-10411
1995
Xanthobacter autotrophicus, Xanthobacter autotrophicus GJ10
Krooshof, G.H.; Ridder, I.S.; Tepper, A.W.J.; Vos, G.J.; Rozeboom, H.J.; Kalk, K.H.; Dijkstra, B.W.; Janssen, D.B.
Kinetic analysis and X-ray structure of haloalkane dehalogenase with a modified halide-binding site
Biochemistry
37
15013-15023
1998
Xanthobacter autotrophicus (P22643), Xanthobacter autotrophicus GJ10 (P22643)
Newman, J.; Peat, T.S.; Richard, R.; Kan, L.; Swanson, P.E.; Affholter, J.A.; Holmes, I.H.; Schindler, J.F.; Unkefer, C.J.; Terwillinger, T.C.
Haloalkane dehalogenases: structure of a Rhodoccocus enzyme
Biochemistry
38
16105-16114
1999
Rhodococcus erythropolis
Schindler, J.F.; Naranjo, P.A.; Honaberger, D.A.; Chang, C.H.; Brainard, J.R.; Vanderberg, L.A.; Unkefer, C.J.
Haloalkane dehalogenases: steady-state kinetics and halide inhibition
Biochemistry
38
5772-5778
1999
Xanthobacter autotrophicus, Rhodococcus erythropolis, Xanthobacter autotrophicus GJ10
Pikkemaat, M.G.; Ridder, I.S.; Rozeboom, H.J.; Klak, K.H.; Dijkstra, B.W.; Janssen, D.B.
Crystallographic and kinetic evidence o a collison complex formed during halide import in haloalkane dehalogenase
Biochemistry
38
12052-12061
1999
Xanthobacter autotrophicus (P22643)
Marek, J.; Vevodova, J.; Smatanova, I.K.; Nagata, Y.; Svensson, L.A.; Newman, J.; Takagi, M.; Damborsky, J.
Crystal structure of a haloalkane dehalogenase from Sphingomonas paucimobilis UT26
Biochemistry
39
14082-14086
2000
Sphingomonas paucimobilis, Sphingomonas paucimobilis UT26
Smatanova, I.; Nagata, Y.; Svensson, L.A.; Takagi, M.; Marek, J.
Crystallization and preliminary X-ray diffraction analysis of a haloalkane dehalogenase LinB from Sphingomonas paucimobilis UT26
Acta Crystallogr. Sect. D
55
1231-1233
1999
Sphingomonas paucimobilis, Sphingomonas paucimobilis UT26
Damborsky, J.; Koca, J.
Analysis of the reaction mechnism and substrate specificity of haloalkane dehalogenases by sequential and structural comparisons
Protein Eng.
12
989-998
1999
Sphingomonas paucimobilis, Rhodococcus rhodochrous, Xanthobacter autotrophicus (P22643), Sphingomonas paucimobilis UT26, Rhodococcus rhodochrous NCIMB 13064, Xanthobacter autotrophicus GJ10 (P22643), Xanthobacter autotrophicus GJ10
Lau, E.Y.; Kahn, K.; Bash, P.A.; Bruice, T.C.
The importance of reactant positioning in enzyme catalysis: a hybrid quantum mechanics /molecular mechanics study of a haloalkane dehalogenase
Proc. Natl. Acad. Sci. USA
97
9937-9942
2000
Xanthobacter autotrophicus (P22643), Xanthobacter autotrophicus GJ10 (P22643), Xanthobacter autotrophicus GJ10
Kmunicek, J.; Luengo, S.; Gago, F.; Ortiz, A.R.; Wade, R.C.; Damborsky, J.
Comparative binding energy analysis of the substrate specificity of haloalkane dehalogenase from Xanthobacter autotrophicus GJ10
Biochemistry
40
8905-8917
2001
Xanthobacter autotrophicus (P22643), Xanthobacter autotrophicus GJ10 (P22643), Xanthobacter autotrophicus GJ10
Bohac, M.; Nagata, Y.; Prokop, M.; Monincova, M.; Tsuda, M.; Koca, J.; Damborsky, J.
Halide-stabilizing residues of haloalkane dehalogenases studied by quantum mechanic calculations and site-directed mutagenesis
Biochemistry
41
14272-14280
2002
Sphingomonas paucimobilis, Rhodococcus erythropolis, Xanthobacter autotrophicus (P22643), Sphingomonas paucimobilis UT26, Xanthobacter autotrophicus GJ10 (P22643)
Oakley, A.J.; Prokop, Z.; Bohac, M.; Kmunicek, J.; Jedlicka, T.; Monincova, M.; Kuta-Smatanova, I.; Nagata, Y.; Damborsky, J.; Wilce, M.C.J.
Exploring the structure and activity of haloalkane dehalogenase from Sphingomonas paucimobilis UT26: evidence for product- and water-mediated inhibition
Biochemistry
41
4847-4855
2002
Sphingomonas paucimobilis, Sphingomonas paucimobilis UT26
Bosma, T.; Pikkemaat, M.G.; Kingma, J.; Dijk, J.; Janssen, D.B.
Steady-state and pre-steady-state kinetic analysis of halopropane conversion by a Rhodococcus haloalkane dehalogenase
Biochemistry
42
8047-8053
2003
Rhodococcus rhodochrous, Rhodococcus rhodochrous NCIMB 13064
Oakley, A.J.; Klvana, M.; Otyepka, M.; Nagata, Y.; Wilce, M.C.J.; Damborsky, J.
Crystal structure of haloalkane dehalogenase LinB from Sphingomonas paucimobilis UT26 at 0.95 A resolution: dynamics of catalytic residues
Biochemistry
43
870-878
2004
Sphingomonas paucimobilis, Sphingomonas paucimobilis UT26
Dravis, B.C.; Swanson, P.E.; Russell, A.J.
Haloalkane hydrolysis with an immobilized haloalkane dehalogenase
Biotechnol. Bioeng.
75
416-423
2001
Rhodococcus rhodochrous
Nam, K.; Prat-Resina, X.; Garcia-Viloca, M.; Devi-Kesavan, L.S.; Gao, J.
Dynamics of an enzymatic substitution reaction in haloalkane dehalogenase
J. Am. Chem. Soc.
126
1369-1376
2004
Xanthobacter autotrophicus (P22643)
Chaloupkova, R.; Sykorova, J.; Prokop, Z.; Jesenska, A.; Moninkova, M.; Pavlova, M.; Tsuda, M.; Nagata, Y.; Damborsky, J.
Modification of acivity and specificity of haloalkane dehalogenase from Sphingomonas paucimobilis UT26, by engineering of its entrance tunnel
J. Biol. Chem.
278
52622-52628
2003
Sphingomonas paucimobilis, Sphingomonas paucimobilis UT26
Kasai, N.; Tsujimura, K.; Unoura, K.; Suzuki, T.
Preparation of (S)-2,3-dichloro-1-propanol by Pseudomonas species and its use in the synthesis of (R)-epichlorohydrin
J. Indust. Microbiol. Biotechnol.
9
97-101
1992
Alcaligenes sp.
-
Nagata, Y.; Prokop, Z.; Sato, Y.; Jerabek, P.; Kumar, A.; Ohtsubo, Y.; Tsuda, M.; Damborsky, J.
Degradation of beta-hexachlorocyclohexane by haloalkane dehalogenase LinB from Sphingomonas paucimobilis UT26
Appl. Environ. Microbiol.
71
2183-2185
2005
Sphingomonas paucimobilis, Sphingomonas paucimobilis UT26
Sato, Y.; Monincova, M.; Chaloupkova, R.; Prokop, Z.; Ohtsubo, Y.; Minamisawa, K.; Tsuda, M.; Damborsky, J.; Nagata, Y.
Two rhizobial strains, Mesorhizobium loti MAFF303099 and Bradyrhizobium japonicum USDA110, encode haloalkane dehalogenases with novel structures and substrate specificities
Appl. Environ. Microbiol.
71
4372-4379
2005
Bradyrhizobium japonicum, Mesorhizobium loti, Bradyrhizobium japonicum USDA 110, Mesorhizobium loti MAFF303099
Jesenska, A.; Pavlova, M.; Strouhal, M.; Chaloupkova, R.; Tesinska, I.; Monincova, M.; Prokop, Z.; Bartos, M.; Pavlik, I.; Rychlik, I.; Moebius, P.; Nagata, Y.; Damborsky, J.
Cloning, biochemical properties, and distribution of mycobacterial haloalkane dehalogenases
Appl. Environ. Microbiol.
71
6736-6745
2005
Mycobacterium tuberculosis variant bovis (Q9XB14), Mycobacterium tuberculosis variant bovis 5033/66 (Q9XB14)
Sharma, P.; Raina, V.; Kumari, R.; Malhotra, S.; Dogra, C.; Kumari, H.; Kohler, H.P.; Buser, H.R.; Holliger, C.; Lal, R.
Haloalkane dehalogenase LinB is responsible for beta- and delta-hexachlorocyclohexane transformation in Sphingobium indicum B90A
Appl. Environ. Microbiol.
72
5720-5727
2006
Sphingobium indicum, Sphingobium indicum (A8CFB7), Sphingobium indicum B90A, Sphingobium indicum UT26, Sphingobium indicum Sp+
Kmunicek, J.; Hynkova, K.; Jedlicka, T.; Nagata, Y.; Negri, A.; Gago, F.; Wade, R.C.; Damborsky, J.
Quantitative analysis of substrate specificity of haloalkane dehalogenase LinB from Sphingomonas paucimobilis UT26
Biochemistry
44
3390-3401
2005
Sphingomonas paucimobilis, Sphingomonas paucimobilis UT26
Torz, M.; Wietzes, P.; Beschkov, V.; Janssen, D.B.
Metabolism of mono- and dihalogenated C1 and C2 compounds by Xanthobacter autotrophicus growing on 1,2-dichloroethane
Biodegradation
18
145-157
2006
Xanthobacter autotrophicus
Erable, B.; Goubet, I.; Lamare, S.; Legoy, M.D.; Maugard, T.
Haloalkane hydrolysis by Rhodococcus erythropolis cells: comparison of conventional aqueous phase dehalogenation and nonconventional gas phase dehalogenation
Biotechnol. Bioeng.
86
47-54
2004
Rhodococcus erythropolis, Rhodococcus erythropolis NCIMB 13064
Erable, B.; Goubet, I.; Lamare, S.; Seltana, A.; Legoy, M.D.; Maugard, T.
Nonconventional hydrolytic dehalogenation of 1-chlorobutane by dehydrated bacteria in a continuous solid-gas biofilter
Biotechnol. Bioeng.
91
304-313
2005
Xanthobacter autotrophicus, Rhodococcus erythropolis, Rhodococcus erythropolis NCIMB 13064
Olaniran, A.O.; Pillay, D.; Pillay, B.
Haloalkane and haloacid dehalogenase from aerobic bacterial isolates indigenous to contaminated sites in Africa demonstrate diverse substrate specificities
Chemosphere
55
27-33
2004
Bacillus sp. (in: Bacteria), Burkholderia sp., Corynebacterium sp., Micrococcus sp., Pseudomonas sp.
Soriano, A.; Silla, E.; Tunon, I.; Ruiz-Lopez, M.F.
Dynamic and electrostatic effects in enzymatic processes. An analysis of the nucleophilic substitution reaction in haloalkane dehalogenase
J. Am. Chem. Soc.
127
1946-1957
2005
Xanthobacter autotrophicus (P22643)
Banas, P.; Otyepka, M.; Jerabek, P.; Petrek, M.; Damborsky, J.
Mechanism of enhanced conversion of 1,2,3-trichloropropane by mutant haloalkane dehalogenase revealed by molecular modeling
J. Comput. Aided Mol. Des.
20
375-383
2006
Rhodococcus sp., Rhodococcus sp. (P0A3G3)
Pavlova, M.; Klva?a, M.; Jesenska, A.; Prokop, Z.; Kone?na, H.; Sato, T.; Tsuda, M.; Nagata, Y.; Damborsky, J.
The identification of catalytic pentad in the haloalkane dehalogenase DhmA from Mycobacterium avium N85: Reaction mechanism and molecular evolution
J. Struct. Biol.
157
384-392
2006
Mycobacterium avium, Mycobacterium avium (Q73Y99), Mycobacterium avium N85
Erable, B.; Maugard, T.; Goubet, I.; Lamare, S.; Legoy, M.D.
Biotransformation of halogenated compounds by lyophilized cells of Rhodococcus erythropolis in a continuous solid-gas biofilter
Process Biochem.
40
45-51
2005
Rhodococcus erythropolis, Rhodococcus erythropolis NCIMB 13064
-
Nakamura, T.; Zamocky, M.; Zdrahal, Z.; Chaloupkova, R.; Monincova, M.; Prokop, Z.; Nagata, Y.; Damborsky, J.
Expression of glycosylated haloalkane dehalogenase LinB in Pichia pastoris
Protein Expr. Purif.
46
85-91
2006
Sphingomonas paucimobilis (P51698), Sphingomonas paucimobilis UT26 (P51698), Sphingomonas paucimobilis UT26
Sato, Y.; Natsume, R.; Tsuda, M.; Damborsky, J.; Nagata, Y.; Senda, T.
Crystallization and preliminary crystallographic analysis of a haloalkane dehalogenase, DbjA, from Bradyrhizobium japonicum USDA110
Acta Crystallogr. Sect. F
63
294-296
2007
Bradyrhizobium japonicum
Monincova, M.; Prokop, Z.; Vevodova, J.; Nagata, Y.; Damborsky, J.
Weak activity of haloalkane dehalogenase LinB with 1,2,3-trichloropropane revealed by X-Ray crystallography and microcalorimetry
Appl. Environ. Microbiol.
73
2005-2008
2007
Sphingobium indicum (A8CFB7)
Ito, M.; Prokop, Z.; Klvana, M.; Otsubo, Y.; Tsuda, M.; Damborsky, J.; Nagata, Y.
Degradation of beta-hexachlorocyclohexane by haloalkane dehalogenase LinB from gamma-hexachlorocyclohexane-utilizing bacterium Sphingobium sp. MI1205
Arch. Microbiol.
188
313-325
2007
Sphingobium sp. (A4PEU6), Sphingobium indicum (A8CFB7), Sphingobium sp. MI1205 (A4PEU6), Sphingobium indicum UT26 (A8CFB7)
Silberstein, M.; Damborsky, J.; Vajda, S.
Exploring the binding sites of the haloalkane dehalogenase DhlA from Xanthobacter autotrophicus GJ10
Biochemistry
46
9239-9249
2007
Rhodococcus sp. (P0A3G3), Xanthobacter autotrophicus (P22643), Sphingomonas paucimobilis (P51698)
Mazumdar, P.A.; Hulecki, J.C.; Cherney, M.M.; Garen, C.R.; James, M.N.
X-ray crystal structure of Mycobacterium tuberculosis haloalkane dehalogenase Rv2579
Biochim. Biophys. Acta
1784
351-362
2008
Mycobacterium tuberculosis (P9WMR9), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WMR9), Mycobacterium tuberculosis H37Rv
Negri, A.; Marco, E.; Damborsky, J.; Gago, F.
Stepwise dissection and visualization of the catalytic mechanism of haloalkane dehalogenase LinB using molecular dynamics simulations and computer graphics
J. Mol. Graph. Model.
26
643-651
2007
Sphingobium indicum (A8CFB7)
Chovancova, E.; Kosinski, J.; Bujnicki, J.M.; Damborsky, J.
Phylogenetic analysis of haloalkane dehalogenases
Proteins
67
305-316
2007
Mycobacterium tuberculosis, Mycobacterium avium, Mycolicibacterium smegmatis, Sphingobium indicum (A8CFB7), Rhodococcus sp. (P0A3G3), Xanthobacter autotrophicus (P22643), Bradyrhizobium japonicum (P59337), Rhodopirellula baltica (Q7UF99), Agrobacterium tumefaciens (Q8U671), Mesorhizobium loti (Q98C03)
Otyepka, M.; Banas, P.; Magistrato, A.; Carloni, P.; Damborsky, J.
Second step of hydrolytic dehalogenation in haloalkane dehalogenase investigated by QM/MM methods
Proteins
70
707-717
2008
Sphingomonas paucimobilis (P51698)
Stsiapanava, A.; Koudelakova, T.; Lapkouski, M.; Pavlova, M.; Damborsky, J.; Smatanova, I.K.
Crystals of DhaA mutants from Rhodococcus rhodochrous NCIMB 13064 diffracted to ultrahigh resolution: crystallization and preliminary diffraction analysis
Acta Crystallogr. Sect. F
64
137-140
2008
Rhodococcus rhodochrous (P0A3G2), Rhodococcus rhodochrous NCIMB 13064 (P0A3G2), Rhodococcus rhodochrous NCIMB 13064
Prudnikova, T.; Mozga, T.; Rezacova, P.; Chaloupkova, R.; Sato, Y.; Nagata, Y.; Brynda, J.; Kuty, M.; Damborsky, J.; Smatanova, I.K.
Crystallization and preliminary X-ray analysis of a novel haloalkane dehalogenase DbeA from Bradyrhizobium elkani USDA94
Acta Crystallogr. Sect. F
65
353-356
2009
Bradyrhizobium elkanii, Bradyrhizobium elkanii USDA94
Raina, V.; Rentsch, D.; Geiger, T.; Sharma, P.; Buser, H.R.; Holliger, C.; Lal, R.; Kohler, H.P.
New metabolites in the degradation of alpha- and gamma-hexachlorocyclohexane (HCH): pentachlorocyclohexenes are hydroxylated to cyclohexenols and cyclohexenediols by the haloalkane dehalogenase LinB from Sphingobium indicum B90A
J. Agric. Food Chem.
56
6594-6603
2008
Sphingobium indicum, Sphingobium indicum B90A
Jesenska, A.; Sykora, J.; Olzynska, A.; Brezovsky, J.; Zdrahal, Z.; Damborsky, J.; Hof, M.
Nanosecond time-dependent Stokes shift at the tunnel mouth of haloalkane dehalogenases
J. Am. Chem. Soc.
131
494-501
2009
Rhodococcus rhodochrous, Bradyrhizobium japonicum (P59337), Bradyrhizobium japonicum USDA 110 (P59337), Rhodococcus rhodochrous NCIMB13064
Murugan, N.A.; Agren, H.
1,2-dichloroethane in haloalkane dehalogenase protein and in water solvent: a case study of confinement effect on structural and dynamical properties
J. Phys. Chem. B
113
3257-3263
2009
Xanthobacter autotrophicus (P22643), Xanthobacter autotrophicus GJ10 (P22643)
Mena-Benitez, G.L.; Gandia-Herrero, F.; Graham, S.; Larson, T.R.; McQueen-Mason, S.J.; French, C.E.; Rylott, E.L.; Bruce, N.C.
Engineering a catabolic pathway in plants for the degradation of 1,2-dichloroethane
Plant Physiol.
147
1192-1198
2008
Xanthobacter autotrophicus (P22643), Xanthobacter autotrophicus GJ10 (P22643), Xanthobacter autotrophicus GJ10
Hasan, K.; Fortova, A.; Koudelakova, T.; Chaloupkova, R.; Ishitsuka, M.; Nagata, Y.; Damborsky, J.; Prokop, Z.
Biochemical characteristics of the novel haloalkane dehalogenase DatA, isolated from the plant pathogen Agrobacterium tumefaciens C58
Appl. Environ. Microbiol.
77
1881-1884
2011
Agrobacterium tumefaciens (E2RV69), Agrobacterium tumefaciens C58 / ATCC 33970 (E2RV69)
Drienovska, I.; Chovancova, E.; Koudelakova, T.; Damborsky, J.; Chaloupkova, R.
Biochemical characterization of a novel haloalkane dehalogenase from a cold-adapted bacterium
Appl. Environ. Microbiol.
78
4995-4998
2012
Psychrobacter cryohalolentis, Psychrobacter cryohalolentis K5
Hesseler, M.; Bogdanovic, X.; Hidalgo, A.; Berenguer, J.; Palm, G.J.; Hinrichs, W.; Bornscheuer, U.T.
Cloning, functional expression, biochemical characterization, and structural analysis of a haloalkane dehalogenase from Plesiocystis pacifica SIR-1
Appl. Microbiol. Biotechnol.
91
1049-1060
2011
Plesiocystis pacifica (A6G7B1)
Koudelakova, T.; Chovancova, E.; Brezovsky, J.; Monincova, M.; Fortova, A.; Jarkovsky, J.; Damborsky, J.
Substrate specificity of haloalkane dehalogenases
Biochem. J.
435
345-354
2011
Agrobacterium tumefaciens, Bradyrhizobium japonicum, Xanthobacter autotrophicus, Mycobacterium tuberculosis variant bovis, Rhodococcus rhodochrous, Sphingobium indicum, Rhodopirellula baltica, Bradyrhizobium elkanii, Bradyrhizobium japonicum USDA 110, Agrobacterium tumefaciens C58 / ATCC 33970, Rhodococcus rhodochrous NCIMB 13064, Bradyrhizobium elkanii USDA94, Rhodopirellula baltica SH1, Xanthobacter autotrophicus GJ10, Sphingobium indicum UT26, Mycobacterium tuberculosis variant bovis 5033/66
van Leeuwen, J.G.; Wijma, H.J.; Floor, R.J.; van der Laan, J.M.; Janssen, D.B.
Directed evolution strategies for enantiocomplementary haloalkane dehalogenases: from chemical waste to enantiopure building blocks
ChemBioChem
13
137-148
2012
Rhodococcus rhodochrous
Bala, K.; Geueke, B.; Miska, M.E.; Rentsch, D.; Poiger, T.; Dadhwal, M.; Lal, R.; Holliger, C.; Kohler, H.P.
Enzymatic conversion of epsilon-hexachlorocyclohexane and a heptachlorocyclohexane isomer, two neglected components of technical hexachlorocyclohexane
Environ. Sci. Technol.
46
4051-4058
2012
Sphingobium indicum, Sphingobium indicum B90A
Chaloupkova, R.; Prokop, Z.; Sato, Y.; Nagata, Y.; Damborsky, J.
Stereoselectivity and conformational stability of haloalkane dehalogenase DbjA from Bradyrhizobium japonicum USDA110: the effect of pH and temperature
FEBS J.
278
2728-2738
2011
Bradyrhizobium japonicum (P59337), Bradyrhizobium japonicum USDA 110 (P59337)
Biedermannova, L.; Prokop, Z.; Gora, A.; Chovancova, E.; Kovacs, M.; Damborsky, J.; Wade, R.C.
A single mutation in a tunnel to the active site changes the mechanism and kinetics of product release in haloalkane dehalogenase LinB
J. Biol. Chem.
287
29062-29074
2012
Sphingobium indicum, Sphingobium indicum UT26
Gehret, J.J.; Gu, L.; Geders, T.W.; Brown, W.C.; Gerwick, L.; Gerwick, W.H.; Sherman, D.H.; Smith, J.L.
Structure and activity of DmmA, a marine haloalkane dehalogenase
Protein Sci.
21
239-248
2012
uncultured marine bacterium, no activity in Moorea producta
Westerbeek, A.; van Leeuwen, J.; Szymanski, W.; Feringa, B.; Janssen, D.
Haloalkane dehalogenase catalysed desymmetrisation and tandem kinetic resolution for the preparation of chiral haloalcohols
Tetrahedron
68
7645-7650
2012
Bradyrhizobium japonicum, Xanthobacter autotrophicus, Sphingomonas paucimobilis, Mesorhizobium loti, Rhodococcus rhodochrous, Bradyrhizobium japonicum USDA 110, Sphingomonas paucimobilis UT26, Mesorhizobium loti MAFF303099, Rhodococcus rhodochrous NCIMB13064, Xanthobacter autotrophicus GJ10
-
Tratsiak, K.; Degtjarik, O.; Drienovska, I.; Chrast, L.; Rezacova, P.; Kuty, M.; Chaloupkova, R.; Damborsky, J.; Kuta Smatanova, I.
Crystallographic analysis of new psychrophilic haloalkane dehalogenases: DpcA from Psychrobacter cryohalolentis K5 and DmxA from Marinobacter sp. ELB17
Acta Crystallogr. Sect. F
69
683-688
2013
Marinobacter sp., Psychrobacter cryohalolentis, Psychrobacter cryohalolentis K5
Guan, L.; Yabuki, H.; Okai, M.; Ohtsuka, J.; Tanokura, M.
Crystal structure of the novel haloalkane dehalogenase DatA from Agrobacterium tumefaciens C58 reveals a special halide-stabilizing pair and enantioselectivity mechanism
Appl. Microbiol. Biotechnol.
98
8573-8582
2014
Agrobacterium tumefaciens (E2RV69), Agrobacterium tumefaciens C58 / ATCC 33970 (E2RV69)
Fibinger, M.P.; Davids, T.; Boettcher, D.; Bornscheuer, U.T.
A selection assay for haloalkane dehalogenase activity based on toxic substrates
Appl. Microbiol. Biotechnol.
99
8955-8962
2015
Rhodococcus rhodochrous (P0A3G2), Xanthobacter autotrophicus (P22643)
Nagata, Y.; Ohtsubo, Y.; Tsuda, M.
Properties and biotechnological applications of natural and engineered haloalkane dehalogenases
Appl. Microbiol. Biotechnol.
99
9865-9881
2015
Arthrobacter sp., Corynebacterium sp., Rhodococcus sp., Sphingomonas sp., Strongylocentrotus purpuratus, Sphingobium indicum, Sphingobium indicum (P51698), Alcanivorax dieselolei, Rhodobacteraceae bacterium UDC319 (A0A023I2Y1), Marinobacter sp. (A3JB27), Sphingobium sp. (A4PEU6), Mycobacterium tuberculosis variant bovis (A4Q9R7), Mycobacterium tuberculosis variant bovis (Q6EUU8), Mycobacterium tuberculosis variant bovis (Q9XB14), Plesiocystis pacifica (A6G7B1), Bradyrhizobium elkanii (E2RV62), Agrobacterium tumefaciens (E2RV69), Rhodopirellula baltica (G3XCP3), Rhodococcus rhodochrous (P0A3G2), Xanthobacter autotrophicus (P22643), Bradyrhizobium japonicum (P59337), Mycobacterium tuberculosis (P9WMR9), Psychrobacter cryohalolentis (Q1QBB9), Mycobacterium avium (Q93K00), Mesorhizobium loti (Q98C03), Mycobacterium sp. (Q9ZER0), Bradyrhizobium japonicum USDA 110 (P59337), Mycobacterium sp. GP1 (Q9ZER0), Psychrobacter cryohalolentis K5 (Q1QBB9), Mycobacterium avium N85 (Q93K00), Mesorhizobium loti MAFF303099 (Q98C03), Agrobacterium tumefaciens C58 / ATCC 33970 (E2RV69), Rhodococcus rhodochrous NCIMB 13064 (P0A3G2), Mycobacterium tuberculosis H37Rv (P9WMR9), Bradyrhizobium elkanii USDA94 (E2RV62), Rhodopirellula baltica SH1 (G3XCP3), Alcanivorax dieselolei B-5, Sphingobium sp. MI1205 (A4PEU6), Sphingobium indicum B90A, Xanthobacter autotrophicus GJ10 (P22643), Sphingobium indicum UT26 (P51698), Mycobacterium tuberculosis variant bovis 5033/66 (A4Q9R7), Mycobacterium tuberculosis variant bovis 5033/66 (Q6EUU8), Mycobacterium tuberculosis variant bovis 5033/66 (Q9XB14), Sphingomonas sp. BHC-A
Fortova, A.; Sebestova, E.; Stepankova, V.; Koudelakova, T.; Palkova, L.; Damborsky, J.; Chaloupkova, R.
DspA from Strongylocentrotus purpuratus: The first biochemically characterized haloalkane dehalogenase of non-microbial origin
Biochimie
95
2091-2096
2013
Strongylocentrotus purpuratus
Koudelakova, T.; Bidmanova, S.; Dvorak, P.; Pavelka, A.; Chaloupkova, R.; Prokop, Z.; Damborsky, J.
Haloalkane dehalogenases: biotechnological applications
Biotechnol. J.
8
32-45
2013
Bradyrhizobium japonicum, Sphingomonas paucimobilis, Rhodococcus rhodochrous, Bradyrhizobium japonicum USDA 110
Hasan, K.; Gora, A.; Brezovsky, J.; Chaloupkova, R.; Moskalikova, H.; Fortova, A.; Nagata, Y.; Damborsky, J.; Prokop, Z.
The effect of a unique halide-stabilizing residue on the catalytic properties of haloalkane dehalogenase DatA from Agrobacterium tumefaciens C58
FEBS J.
280
3149-3159
2013
Agrobacterium tumefaciens (E2RV69), Agrobacterium tumefaciens C58 / ATCC 33970 (E2RV69)
Novak, H.R.; Sayer, C.; Isupov, M.N.; Gotz, D.; Spragg, A.M.; Littlechild, J.A.
Biochemical and structural characterisation of a haloalkane dehalogenase from a marine Rhodobacteraceae
FEBS Lett.
588
1616-1622
2014
Rhodobacteraceae
Okai, M.; Ohtsuka, J.; Imai, L.F.; Mase, T.; Moriuchi, R.; Tsuda, M.; Nagata, K.; Nagata, Y.; Tanokura, M.
Crystal structure and site-directed mutagenesis analyses of haloalkane dehalogenase LinB from Sphingobium sp. strain MI1205
J. Bacteriol.
195
2642-2651
2013
Sphingobium indicum, Sphingobium sp. (A4PEU6), Sphingobium sp. MI1205 (A4PEU6), Sphingobium indicum UT26
Jimenez, D.; Dini-Andreote, F.; Ottoni, J.; de Oliveira, V.; van Elsas, J.; Andreote, F.
Compositional profile of alpha/beta-hydrolase fold proteins in mangrove soil metagenomes: Prevalence of epoxide hydrolases and haloalkane dehalogenases in oil-contaminated sites
Microb. Biotechnol.
8
604-613
2015
Aeromicrobium marinum, Alcanivorax borkumensis, Anaeromyxobacter sp. K, Chloroflexus sp., Moritella sp., Mycobacterium marinum, Mycolicibacterium vanbaalenii, Oceanicaulis alexandrii, Photobacterium profundum, Salinispora arenicola
Fung, H.; Gadd, M.; Drury, T.; Cheung, S.; Guss, J.; Coleman, N.; Matthews, J.
Biochemical and biophysical characterisation of haloalkane dehalogenases DmrA and DmrB in Mycobacterium strain JS60 and their role in growth on haloalkanes
Mol. Microbiol.
97
439-453
2015
Mycolicibacterium rhodesiae (G4I2J6), Mycolicibacterium rhodesiae (G4I5P8), Mycolicibacterium rhodesiae JS60 (G4I2J6), Mycolicibacterium rhodesiae JS60 (G4I5P8)
Li, A.; Shao, Z.
Biochemical characterization of a haloalkane dehalogenase DadB from Alcanivorax dieselolei B-5
PLoS ONE
9
e89144
2014
Alcanivorax dieselolei (K0CAI2), Alcanivorax dieselolei, Alcanivorax dieselolei B-5 (K0CAI2)
Kumar, A.; Pillay, B.; Olaniran, A.O.
Cloning, expression, purification and three-dimensional structure prediction of haloalkane dehalogenase from a recently isolated Ancylobacter aquaticus strain UV5
Protein Expr. Purif.
99
10-17
2014
Ancylobacter aquaticus (B8YPW8), Ancylobacter aquaticus, Ancylobacter aquaticus UV5 (B8YPW8), Ancylobacter aquaticus UV5
Ang, T.F.; Salleh, A.B.; Normi, Y.M.; Leow, T.C.
In silico design of potentially functional artificial metallo-haloalkane dehalogenase containing catalytic zinc
3 Biotech
8
314
2018
Rhodococcus rhodochrous (P0A3G2)
Tratsiak, K.; Prudnikova, T.; Drienovska, I.; Damborsky, J.; Brynda, J.; Pachl, P.; Kuty, M.; Chaloupkova, R.; Rezacova, P.; Kuta Smatanova, I.
Crystal structure of the cold-adapted haloalkane dehalogenase DpcA from Psychrobacter cryohalolentis K5
Acta Crystallogr. Sect. F
75
324-331
2019
Psychrobacter cryohalolentis (Q1QBB9), Psychrobacter cryohalolentis K5 (Q1QBB9), Psychrobacter cryohalolentis K5
Buryska, T.; Daniel, L.; Kunka, A.; Brezovsky, J.; Damborsky, J.; Prokop, Z.
Discovery of novel haloalkane dehalogenase inhibitors
Appl. Environ. Microbiol.
82
1958-1965
2016
Mycobacterium tuberculosis (P9WMR9), Mycobacterium tuberculosis H37Rv (P9WMR9), Mycobacterium tuberculosis H37Rv
Buryska, T.; Babkova, P.; Vavra, O.; Damborsky, J.; Prokop, Z.
A haloalkane dehalogenase from a marine microbial consortium possessing exceptionally broad substrate specificity
Appl. Environ. Microbiol.
84
e01684-17
2018
Lyngbya majuscula (Q6DND9)
Kotik, M.; Vanacek, P.; Kunka, A.; Prokop, Z.; Damborsky, J.
Metagenome-derived haloalkane dehalogenases with novel catalytic properties
Appl. Microbiol. Biotechnol.
101
6385-6397
2017
uncultured bacterium
Tang, X.; Zhang, R.; Li, Y.; Zhang, Q.; Wang, W.
Enantioselectivity of haloalkane dehalogenase LinB on the degradation of 1,2-dichloropropane A QM/MM study
Bioorg. Chem.
73
16-23
2017
Sphingomonas paucimobilis, Sphingomonas paucimobilis UT26S
Gross, J.; Prokop, Z.; Janssen, D.; Faber, K.; Hall, M.
Regio- and enantioselective sequential dehalogenation of rac-1,3-dibromobutane by haloalkane dehalogenase LinB
ChemBioChem
17
1437-1441
2016
Sphingobium indicum (D4Z2G1), Sphingobium indicum UT26 (D4Z2G1)
Wang, F.; Song, T.; Jiang, H.; Pei, C.; Huang, Q.; Xi, H.
Bacillus subtilis spore surface display of haloalkane dehalogenase DhaA
Curr. Microbiol.
76
1161-1167
2019
Rhodococcus rhodochrous (P0A3G2), Rhodococcus rhodochrous NCIMB 13064 (P0A3G2), Rhodococcus rhodochrous NCIMB 13064
Zheng, H.; Yu, W.L.; Guo, X.; Zhao, Y.Z.; Cui, Y.; Hu, T.; Zhong, J.Y.
An effective immobilized haloalkane dehalogenase DhaA from Rhodococcus rhodochrous by adsorption, crosslink and PEGylation on meso-cellular foam
Int. J. Biol. Macromol.
125
1016-1023
2019
Rhodococcus rhodochrous (P0A3G2), Rhodococcus rhodochrous
Kokkonen, P.; Bednar, D.; Dockalova, V.; Prokop, Z.; Damborsky, J.
Conformational changes allow processing of bulky substrates by a haloalkane dehalogenase with a small and buried active site
J. Biol. Chem.
293
11505-11512
2018
Xanthobacter autotrophicus (P22643), Xanthobacter autotrophicus GJ10 (P22643), Xanthobacter autotrophicus GJ10
Zhao, Y.Z.; Yu, W.L.; Zheng, H.; Guo, X.; Guo, N.; Hu, T.; Zhong, J.Y.
PEGylation with the thiosuccinimido butylamine linker significantly increases the stability of haloalkane dehalogenase DhaA
J. Biotechnol.
254
25-33
2017
Rhodococcus rhodochrous (P0A3G2)
Marques, S.M.; Dunajova, Z.; Prokop, Z.; Chaloupkova, R.; Brezovsky, J.; Damborsky, J.
Catalytic cycle of haloalkane dehalogenases toward unnatural substrates explored by computational modeling
J. Chem. Inf. Model.
57
1970-1989
2017
Rhodococcus rhodochrous (P0A3G2)
Daud, N.H.; Leow, T.C.; Oslan, S.N.; Salleh, A.B.
A Novel mini protein design of haloalkane dehalogenase
Mol. Biotechnol.
61
477-488
2019
Xanthobacter autotrophicus (P22643), Xanthobacter autotrophicus GJ10 (P22643)
Fung, H.; Gadd, M.; Drury, T.; Cheung, S.; Guss, J.; Coleman, N.; Matthews, J.
Biochemical and biophysical characterisation of haloalkane dehalogenases DmrA and DmrB in Mycobacterium strain JS60 and their role in growth on haloalkanes
Mol. Microbiol.
97
439-453
2015
Mycolicibacterium rhodesiae (G4I2J6), Mycolicibacterium rhodesiae (G4I5P8), Mycolicibacterium rhodesiae JS60 (G4I2J6), Mycolicibacterium rhodesiae JS60 (G4I5P8)
Carlucci, L.; Zhou, E.; Malashkevich, V.N.; Almo, S.C.; Mundorff, E.C.
Biochemical characterization of two haloalkane dehalogenases DccA from Caulobacter crescentus and DsaA from Saccharomonospora azurea
Protein Sci.
25
877-886
2016
Caulobacter vibrioides (Q9A919), Caulobacter vibrioides, Caulobacter vibrioides ATCC 19089 (Q9A919), Saccharomonospora azurea
Bendigiri, C.; Zinjarde, S.; RaviKumar, A.
Ylehd, an epoxide hydrolase with promiscuous haloalkane dehalogenase activity from tropical marine yeast Yarrowia lipolytica is induced upon xenobiotic stress
Sci. Rep.
7
11887
2017
Yarrowia lipolytica (Q6C598), Yarrowia lipolytica, Yarrowia lipolytica CLIB 122 (Q6C598)
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