Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.8.1.5 extracted from

  • Lau, E.Y.; Kahn, K.; Bash, P.A.; Bruice, T.C.
    The importance of reactant positioning in enzyme catalysis: a hybrid quantum mechanics /molecular mechanics study of a haloalkane dehalogenase (2000), Proc. Natl. Acad. Sci. USA, 97, 9937-9942.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.8.1.5

Organism

Organism UniProt Comment Textmining
Xanthobacter autotrophicus P22643 GJ10
-
Xanthobacter autotrophicus GJ10 P22643 GJ10
-

Reaction

Reaction Comment Organism Reaction ID
1-haloalkane + H2O = a primary alcohol + halide alpha/beta hydrolase with catalytic triad, i.e. nucleophile (Asp124)-histidine (H289)-acid (Asp260), during catalytic reaction Xanthobacter autotrophicus
a
1-haloalkane + H2O = a primary alcohol + halide GJ10, detailed reaction mechanism and energetics calculated from computational model Xanthobacter autotrophicus
a

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 calculation of activation energetics for haloalkane hydrolysis Xanthobacter autotrophicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,2-dichloroethane + H2O
-
 Xanthobacter autotrophicus 2-chloroethanol + chloride
-
 ?
1,2-dichloroethane + H2O
-
 Xanthobacter autotrophicus GJ10 2-chloroethanol + chloride
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.2
-
-
 Xanthobacter autotrophicus