Reference on EC 3.5.1.23 - ceramidase and Organism(s) Homo sapiens and UniProt Accession Q9NUN7
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Levade, T.; Tempesta, M.C.; Moser, H.W.; Fensom, A.H.; Harzer, K.; Moser, A.B.; Salvayre, R.
Sulfatide and sphingomyelin loading of living cells as tools for the study of ceramide turnover by lysosomal ceramidase - implications for the diagnosis of Farber disease
Biochem. Mol. Med.
54
117-125
1995
Homo sapiens
Bernardo, K.; Hurwitz, R.; Zenk, T.; Desnick, R.J.; Ferlinz, K.; Schuchman, E.H.; Sandhoff, K.
Purification, characterization, and biosynthesis of human acid ceramidase
J. Biol. Chem.
270
11098-11102
1995
Homo sapiens
Linke, T.; Lansmann, S.; Sandhoff, K.
Purification of acid ceramidase from human pacenta
Methods Enzymol.
311
201-207
1999
Homo sapiens
Romiti, E.; Vasta, V.; Meacci, E.; Farnararo, M.; Linke, T.; Ferlinz, K.; Sandhoff, K.; Bruni, P.
Characterization of sphingomyelinase activity released by thrombin-stimulated platelets
Mol. Cell. Biochem.
205
75-81
2000
Homo sapiens
He, X.; Okino, N.; Dhami, R.; Dagan, A.; Gatt, S.; Schulze, H.; Sandhoff, K.; Schuchman, E.H.
Purification and characterization of recombinant, human acid ceramidase. Catalytic reactions and interactions with acid sphingomyelinase
J. Biol. Chem.
278
32978-32986
2003
Homo sapiens
Hwang, Y.H.; Tani, M.; Nakagawa, T.; Okino, N.; Ito, M.
Subcellular localization of human neutral ceramidase expressed in HEK293 cells
Biochem. Biophys. Res. Commun.
331
37-42
2005
Homo sapiens (Q9NR71), Homo sapiens
Galadari, S.; Wu, B.X.; Mao, C.; Roddy, P.; El Bawab, S.; Hannun, Y.A.
Identification of a novel amidase motif in neutral ceramidase
Biochem. J.
393
687-695
2006
no activity in Saccharomyces cerevisiae, Rattus norvegicus (Q91XT9), Homo sapiens (Q9NR71), Homo sapiens
Xu, R.; Jin, J.; Hu, W.; Sun, W.; Bielawski, J.; Szulc, Z.; Taha, T.; Obeid, L.M.; Mao, C.
Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P
FASEB J.
20
1813-1825
2006
Homo sapiens (Q5QJU3), Homo sapiens
Elojeimy, S.; Holman, D.H.; Liu, X.; El-Zawahry, A.; Villani, M.; Cheng, J.C.; Mahdy, A.; Zeidan, Y.; Bielwaska, A.; Hannun, Y.A.; Norris, J.S.
New insights on the use of desipramine as an inhibitor for acid ceramidase
FEBS Lett.
580
4751-4756
2006
Homo sapiens
Chavez, J.A.; Holland, W.L.; Baer, J.; Sandhoff, K.; Summers, S.A.
Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling
J. Biol. Chem.
280
20148-20153
2005
Homo sapiens
Monick, M.M.; Mallampalli, R.K.; Bradford, M.; McCoy, D.; Gross, T.J.; Flaherty, D.M.; Powers, L.S.; Cameron, K.; Kelly, S.; Merrill, A.H.; Hunninghake, G.W.
Cooperative prosurvival activity by ERK and Akt in human alveolar macrophages is dependent on high levels of acid ceramidase activity
J. Immunol.
173
123-135
2004
Homo sapiens
Houben, E.; Holleran, W.M.; Yaginuma, T.; Mao, C.; Obeid, L.M.; Rogiers, V.; Takagi, Y.; Elias, P.M.; Uchida, Y.
Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis
J. Lipid Res.
47
1063-1070
2006
Homo sapiens (Q5QJU3)
Duan, R.
Sphingomyelinase and ceramidase in the intestinal tract
Eur. J. Lipid Sci. Technol.
109
987-993
2007
Homo sapiens
-
Park, J.; Schuchman, E.H.
Acid ceramidase and human disease
Biochim. Biophys. Acta
1758
2133-2138
2006
Homo sapiens
Ohlsson, L.; Palmberg, C.; Duan, R.D.; Olsson, M.; Bergman, T.; Nilsson, A.
Purification and characterization of human intestinal neutral ceramidase
Biochimie
89
950-960
2007
Homo sapiens
Saad, A.F.; Meacham, W.D.; Bai, A.; Anelli, V.; Elojeimy, S.; Mahdy, A.E.; Turner, L.S.; Cheng, J.; Bielawska, A.; Bielawski, J.; Keane, T.E.; Obeid, L.M.; Hannun, Y.A.; Norris, J.S.; Liu, X.
The functional effects of acid ceramidase overexpression in prostate cancer progression and resistance to chemotherapy
Cancer Biol. Ther.
6
1455-1460
2007
Homo sapiens
Kim, H.L.; Satta, Y.
Population genetic analysis of the N-acylsphingosine amidohydrolase gene associated with mental activity in humans
Genetics
178
1505-1515
2008
Homo sapiens
Shtraizent, N.; Eliyahu, E.; Park, J.H.; He, X.; Shalgi, R.; Schuchman, E.H.
Autoproteolytic cleavage and activation of human acid ceramidase
J. Biol. Chem.
283
11253-11259
2008
Homo sapiens
Sun, W.; Xu, R.; Hu, W.; Jin, J.; Crellin, H.A.; Bielawski, J.; Szulc, Z.M.; Thiers, B.H.; Obeid, L.M.; Mao, C.
Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal keratinocytes
J. Invest. Dermatol.
128
389-397
2008
Homo sapiens (Q13510), Homo sapiens (Q8TDN7), Homo sapiens
Mao, C.; Obeid, L.M.
Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate
Biochim. Biophys. Acta
1781
424-434
2008
Homo sapiens, Homo sapiens (Q5QJU3), Homo sapiens (Q8TDN7), Homo sapiens (Q9NR71), Homo sapiens (Q9NUN7), Mus musculus (Q8R4X1), Mus musculus (Q8VD53), Mus musculus (Q9D099), Mus musculus (Q9JHE3), Mus musculus (Q9WV54), Mus musculus
Lucki, N.; Sewer, M.B.
The cAMP-responsive element binding protein (CREB) regulates the expression of acid ceramidase (ASAH1) in H295R human adrenocortical cells
Biochim. Biophys. Acta
1791
706-713
2009
Homo sapiens
Sun, W.; Hu, W.; Xu, R.; Jin, J.; Szulc, Z.M.; Zhang, G.; Galadari, S.H.; Obeid, L.M.; Mao, C.
Alkaline ceramidase 2 regulates beta1 integrin maturation and cell adhesion
FASEB J.
23
656-666
2009
Homo sapiens
Mahdy, A.E.; Cheng, J.C.; Li, J.; Elojeimy, S.; Meacham, W.D.; Turner, L.S.; Bai, A.; Gault, C.R.; McPherson, A.S.; Garcia, N.; Beckham, T.H.; Saad, A.; Bielawska, A.; Bielawski, J.; Hannun, Y.A.; Keane, T.E.; Taha, M.I.; Hammouda, H.M.; Norris, J.S.; Liu, X.
Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer
Mol. Ther.
17
430-438
2009
Homo sapiens
Claus, R.A.; Dorer, M.J.; Bunck, A.C.; Deigner, H.P.
Inhibition of sphingomyelin hydrolysis: targeting the lipid mediator ceramide as a key regulator of cellular fate
Curr. Med. Chem.
16
1978-2000
2009
Homo sapiens
Liu, X.; Cheng, J.C.; Turner, L.S.; Elojeimy, S.; Beckham, T.H.; Bielawska, A.; Keane, T.E.; Hannun, Y.A.; Norris, J.S.
Acid ceramidase upregulation in prostate cancer: role in tumor development and implications for therapy
Expert Opin. Ther. Targets
13
1449-1458
2009
Homo sapiens
Eliyahu, E.; Shtraizent, N.; Martinuzzi, K.; Barritt, J.; He, X.; Wei, H.; Chaubal, S.; Copperman, A.B.; Schuchman, E.H.
Acid ceramidase improves the quality of oocytes and embryos and the outcome of in vitro fertilization
FASEB J.
24
1229-1238
2010
Homo sapiens
Xu, R.; Sun, W.; Jin, J.; Obeid, L.M.; Mao, C.
Role of alkaline ceramidases in the generation of sphingosine and its phosphate in erythrocytes
FASEB J.
24
2507-2515
2010
Homo sapiens, Mus musculus
Mao, Z.; Sun, W.; Xu, R.; Novgorodov, S.; Szulc, Z.M.; Bielawski, J.; Obeid, L.M.; Mao, C.
Alkaline ceramidase 2 (ACER2) and its product dihydrosphingosine mediate the cytotoxicity of 4-HPR in tumor cells
J. Biol. Chem.
285
29087-29090
2010
Homo sapiens
Hu, W.; Xu, R.; Sun, W.; Szulc, Z.M.; Bielawski, J.; Obeid, L.M.; Mao, C.
Alkaline ceramidase 3 (ACER3) hydrolyzes unsaturated long-chain ceramides, and its down-regulation inhibits both cell proliferation and apoptosis
J. Biol. Chem.
285
7964-7976
2010
Homo sapiens
Sun, W.; Jin, J.; Xu, R.; Hu, W.; Szulc, Z.M.; Bielawski, J.; Obeid, L.M.; Mao, C.
Substrate specificity, membrane topology, and activity regulation of human alkaline ceramidase 2 (ACER2)
J. Biol. Chem.
285
8995-9007
2010
Homo sapiens
ONeill, S.M.; Houck, K.L.; Yun, J.K.; Fox, T.E.; Kester, M.
AP-1 binding transcriptionally regulates human neutral ceramidase
Arch. Biochem. Biophys.
511
31-39
2011
Homo sapiens
Canals, D.; Perry, D.M.; Jenkins, R.W.; Hannun, Y.A.
Drug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases
Br. J. Pharmacol.
163
694-712
2011
Homo sapiens, Homo sapiens (Q13510), Homo sapiens (Q8TDN7), Homo sapiens (Q9NR71)
Park, J.; Yoon, S.
Ceramide, a crucial functional lipid, and its metabolic regulation by acid ceramidase
Food Sci. Biotechnol.
19
859-864
2010
Homo sapiens, Mus musculus
-
Beckham, T.H.; Lu, P.; Cheng, J.C.; Zhao, D.; Turner, L.S.; Zhang, X.; Hoffman, S.; Armeson, K.E.; Liu, A.; Marrison, T.; Hannun, Y.A.; Liu, X.
Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B
Int. J. Cancer
131
2034-2043
2012
Homo sapiens
Jenkins, R.W.; Clarke, C.J.; Canals, D.; Snider, A.J.; Gault, C.R.; Heffernan-Stroud, L.; Wu, B.X.; Simbari, F.; Roddy, P.; Kitatani, K.; Obeid, L.M.; Hannun, Y.A.
Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase
J. Biol. Chem.
286
13292-13303
2011
Homo sapiens
Draper, J.M.; Xia, Z.; Smith, R.A.; Zhuang, Y.; Wang, W.; Smith, C.D.
Discovery and evaluation of inhibitors of human ceramidase
Mol. Cancer Ther.
10
2052-2061
2011
Homo sapiens
Lucki, N.C.; Bandyopadhyay, S.; Wang, E.; Merrill, A.H.; Sewer, M.B.
Acid ceramidase (ASAH1) is a global regulator of steroidogenic capacity and adrenocortical gene expression
Mol. Endocrinol.
26
228-243
2012
Homo sapiens, Homo sapiens (Q13510)
Pizzirani, D.; Bach, A.; Realini, N.; Armirotti, A.; Mengatto, L.; Bauer, I.; Girotto, S.; Pagliuca, C.; De Vivo, M.; Summa, M.; Ribeiro, A.; Piomelli, D.
Benzoxazolone carboxamides: potent and systemically active inhibitors of intracellular acid ceramidase
Angew. Chem. Int. Ed. Engl.
54
485-489
2015
Homo sapiens (Q13510), Mus musculus (Q9WV54)
Morad, S.; Levin, J.; Tan, S.; Fox, T.; Feith, D.; Cabot, M.
Novel off-target effect of tamoxifen - inhibition of acid ceramidase activity in cancer cells
Biochim. Biophys. Acta
1831
1657-1664
2013
Homo sapiens (Q13510)
Ito, M.; Okino, N.; Tani, M.
New insight into the structure, reaction mechanism, and biological functions of neutral ceramidase
Biochim. Biophys. Acta
1841
682-691
2014
Dictyostelium discoideum, Mycobacterium tuberculosis, Oryza sativa, Pseudomonas aeruginosa, Tribolium castaneum, Dermatophilus congolensis, Triticum aestivum (A9YFM2), Aspergillus oryzae (Q5B5D5), Danio rerio (Q5W7F1), Rattus norvegicus (Q91XT9), Mus musculus (Q9JHE3), Homo sapiens (Q9NR71), Drosophila melanogaster (Q9VA70), Laodelphax striatellus (R4N4U2)
Bhabak, K.; Proksch, D.; Redmer, S.; Arenz, C.
Novel fluorescent ceramide derivatives for probing ceramidase substrate specificity
Bioorg. Med. Chem.
20
6154-6161
2012
Homo sapiens (Q13510), Homo sapiens (Q9NR71)
Bhabak, K.; Arenz, C.
Novel amide- and sulfonamide-based aromatic ethanolamines: Effects of various substituents on the inhibition of acid and neutral ceramidases
Bioorg. Med. Chem.
20
6162-6170
2012
Homo sapiens (Q13510), Homo sapiens (Q9NR71)
Bhabak, K.P.; Kleuser, B.; Huwiler, A.; Arenz, C.
Effective inhibition of acid and neutral ceramidases by novel B-13 and LCL-464 analogues
Bioorg. Med. Chem.
21
874-882
2013
Homo sapiens (Q13510), Homo sapiens (Q9NR71)
Bhabak, K.P.; Hauser, A.; Redmer, S.; Banhart, S.; Heuer, D.; Arenz, C.
Development of a novel FRET probe for the real-time determination of ceramidase activity
ChemBioChem
14
1049-1052
2013
Homo sapiens (Q9NR71), Mus musculus (Q9WV54)
Cheng, J.; Bai, A.; Beckham, T.; Tucker Marrison, S.; Yount, C.; Young, K.; Lu, P.; Bartlett, A.; Wu, B.; Keane, B.; Armeson, K.; Marshall, D.; Keane, T.; Smith, M.; Ellen Jones, E.; Drake Jr., R.; Bielawska, A.; Norris, J.; Liu, X.
Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse
J. Clin. Invest.
123
4344-4358
2013
Homo sapiens (Q13510), Homo sapiens
Camacho, L.; Meca-Cortes, O.; Abad, J.L.; Garcia, S.; Rubio, N.; Diaz, A.; Celia-Terrassa, T.; Cingolani, F.; Bermudo, R.; Fernandez, P.L.; Blanco, J.; Delgado, A.; Casas, J.; Fabrias, G.; Thomson, T.M.
Acid ceramidase as a therapeutic target in metastatic prostate cancer
J. Lipid Res.
54
1207-1220
2013
Homo sapiens (Q13510)
Lucki, N.C.; Li, D.; Bandyopadhyay, S.; Wang, E.; Merrill, A.H.; Sewer, M.B.
Acid ceramidase (ASAH1) represses steroidogenic factor 1-dependent gene transcription in H295R human adrenocortical cells by binding to the receptor
Mol. Cell. Biol.
32
4419-4431
2012
Homo sapiens (Q13510), Homo sapiens
Alves, M.; Trionnaire, E.; Ribeiro, I.; Carpentier, S.; Harzer, K.; Levade, T.; Ribeiro, M.
Molecular basis of acid ceramidase deficiency in a neonatal form of Farber disease: identification of the first large deletion in ASAH1 gene
Mol. Genet. Metab.
109
276-281
2013
Homo sapiens (Q13510), Homo sapiens
Beckham, T.H.; Cheng, J.C.; Lu, P.; Marrison, S.T.; Norris, J.S.; Liu, X.
Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signaling
PLoS ONE
8
e76593
2013
Homo sapiens (Q13510), Homo sapiens
Realini, N.; Solorzano, C.; Pagliuca, C.; Pizzirani, D.; Armirotti, A.; Luciani, R.; Costi, M.P.; Bandiera, T.; Piomelli, D.
Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity
Sci. Rep.
3
1035
2013
Homo sapiens (Q13510), Homo sapiens, Rattus norvegicus (Q6P7S1)
Coant, N.; Hannun, Y.A.
Neutral ceramidase advances in mechanisms, cell regulation, and roles in cancer
Adv. Biol. Regul.
71
141-146
2019
Nilaparvata lugens, Amorphophallus muelleri (A0A2D1WBF2), Rattus norvegicus (Q91XT9), Mus musculus (Q9JHE3), Homo sapiens (Q9NR71)
Azuma, M.M.; Balani, P.; Boisvert, H.; Gil, M.; Egashira, K.; Yamaguchi, T.; Hasturk, H.; Duncan, M.; Kawai, T.; Movila, A.
Endogenous acid ceramidase protects epithelial cells from Porphyromonas gingivalis-induced inflammation in vitro
Biochem. Biophys. Res. Commun.
495
2383-2389
2018
Homo sapiens (Q13510), Homo sapiens
Bai, A.; Bielawska, A.; Rahmaniyan, M.; Kraveka, J.M.; Bielawski, J.; Hannun, Y.A.
Dose dependent actions of LCL521 on acid ceramidase and key sphingolipid metabolites
Bioorg. Med. Chem.
26
6067-6075
2018
Homo sapiens (Q13510)
Baduva, K.; Buechter, L.; Kreyenkamp, K.; Westphal, L.; Wilker, B.; Kohnen, M.; Schuchman, E.H.; Edwards, M.J.; Becker, K.A.; Gulbins, E.; Carpinteiro, A.
Signalling effects induced by acid ceramidase in human epithelial or leukemic cell lines
Cell. Physiol. Biochem.
52
1092-1102
2019
Homo sapiens (Q13510), Homo sapiens
Ferraz, M.J.; Marques, A.R.; Appelman, M.D.; Verhoek, M.; Strijland, A.; Mirzaian, M.; Scheij, S.; Ouairy, C.M.; Lahav, D.; Wisse, P.; Overkleeft, H.S.; Boot, R.G.; Aerts, J.M.
Lysosomal glycosphingolipid catabolism by acid ceramidase formation of glycosphingoid bases during deficiency of glycosidases
FEBS Lett.
590
716-725
2016
Homo sapiens (Q13510), Homo sapiens, Mus musculus (Q9WV54)
Ordonez, Y.F.; Abad, J.L.; Aseeri, M.; Casas, J.; Garcia, V.; Casasampere, M.; Schuchman, E.H.; Levade, T.; Delgado, A.; Triola, G.; Fabrias, G.
Activity-based imaging of acid ceramidase in living cells
J. Am. Chem. Soc.
141
7736-7742
2019
Homo sapiens (Q13510)
Sakamoto, W.; Coant, N.; Canals, D.; Obeid, L.M.; Hannun, Y.A.
Functions of neutral ceramidase in the Golgi apparatus
J. Lipid Res.
59
2116-2125
2018
Homo sapiens (Q9NR71)
Tan, S.F.; Dunton, W.; Liu, X.; Fox, T.E.; Morad, S.A.F.; Desai, D.; Doi, K.; Conaway, M.R.; Amin, S.; Claxton, D.F.; Wang, H.G.; Kester, M.; Cabot, M.C.; Feith, D.J.; Loughran, T.P.
Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-kappaB-dependent P-glycoprotein upregulation
J. Lipid Res.
60
1078-1086
2019
Homo sapiens (Q13510), Homo sapiens
Gebai, A.; Gorelik, A.; Li, Z.; Illes, K.; Nagar, B.
Structural basis for the activation of acid ceramidase
Nat. Commun.
9
1621
2018
Homo sapiens (Q9NUN7)
Vasiliauskaite-Brooks, I.; Healey, R.D.; Rochaix, P.; Saint-Paul, J.; Sounier, R.; Grison, C.; Waltrich-Augusto, T.; Fortier, M.; Hoh, F.; Saied, E.M.; Arenz, C.; Basu, S.; Leyrat, C.; Granier, S.
Structure of a human intramembrane ceramidase explains enzymatic dysfunction found in leukodystrophy
Nat. Commun.
9
5437
2018
Homo sapiens (Q9NUN7), Homo sapiens
Vasiliauskaite-Brooks, I.; Sounier, R.; Rochaix, P.; Bellot, G.; Fortier, M.; Hoh, F.; De Colibus, L.; Bechara, C.; Saied, E.M.; Arenz, C.; Leyrat, C.; Granier, S.
Structural insights into adiponectin receptors suggest ceramidase activity
Nature
544
120-123
2017
Homo sapiens (Q86V24)
Leclerc, J.; Garandeau, D.; Pandiani, C.; Gaudel, C.; Bille, K.; Nottet, N.; Garcia, V.; Colosetti, P.; Pagnotta, S.; Bahadoran, P.; Tondeur, G.; Mograbi, B.; Dalle, S.; Caramel, J.; Levade, T.; Ballotti, R.; Andrieu-Abadie, N.; Bertolotto, C.
Lysosomal acid ceramidase ASAH1 controls the transition between invasive and proliferative phenotype in melanoma cells
Oncogene
38
1282-1295
2019
Homo sapiens (Q13510), Homo sapiens
Doan, N.B.; Nguyen, H.S.; Al-Gizawiy, M.M.; Mueller, W.M.; Sabbadini, R.A.; Rand, S.D.; Connelly, J.M.; Chitambar, C.R.; Schmainda, K.M.; Mirza, S.P.
Acid ceramidase confers radioresistance to glioblastoma cells
Oncol. Rep.
38
1932-1940
2017
Homo sapiens (Q13510)
Malinina, L.; Brown, R.E.
Catalytic mechanism of eukaryotic neutral ceramidase
Structure
23
1371-1372
2015
Homo sapiens (Q9NR71), Homo sapiens
