Cloned (Comment) | Organism |
---|---|
gene ASAH1, expression analysis | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2E,4E)-N-[(2S,3R)-1,3-dihydroxyoctadecan-2-yl]hexa-2,4-dienamide | - |
Homo sapiens | |
(E)-4-[(2S,3R)-N-1,3-dihydroxyoctadecan-2-ylamino]4-oxo-2-butenoic acid | - |
Homo sapiens | |
(E)-N-[(2S,3R)-1,3-dihydroxyoctadecan-2-yl]but-2-enamide | - |
Homo sapiens | |
N-[(2S 3R)-1,3-dihydroxyoctadecan-2-yl]3-methyl-2-butenamide. | - |
Homo sapiens | |
N-[(2S,3R)-1,3-dihydroxyoctadecan-2-yl]2,2-dibromoacetamide | strong inhibition | Homo sapiens | |
N-[(2S,3R)-1,3-dihydroxyoctadecan-2-yl]2-bromoacetamide | strong inhibition | Homo sapiens | |
N-[(2S,3R)-1,3-dihydroxyoctadecan-2-yl]2-methylacrylamide | strong inhibition | Homo sapiens | |
N-[(2S,3R)-1,3-dihydroxyoctadecan-2-yl]acrylamide | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q13510 | gene ASAH1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
PC-3 cell | high enzyme level, increased expression of acid ceramidase in highly metastatic clones derived from PC-3 prostate cancer cells. The highly aggressive and metastatic PC-3/Mc cells display levels of acid ceramidase activity that are 2.5 to 4times higher than those of PC-3/S cells | Homo sapiens | - |
prostate cancer cell | high enzyme level | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
acid ceramidase | - |
Homo sapiens |
ASAH1 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
4.5 | - |
assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | ASAH1-knockdown PC-3/Mc cells show impairment of ceramide catabolism with increased sphingosine levels, sphingolipid content, overview. ASAH1 knockdown by shRNA inhibits the growth of PC-3/Mc cells under low-density and low-serum conditions and abrogates their anchorage-independent colony-forming potential | Homo sapiens |
metabolism | acid ceramidase catalyzes the hydrolysis of ceramide into sphingosine, in turn a substrate of sphingosine kinases that catalyze its conversion into the mitogenic sphingosine 1-phosphate | Homo sapiens |