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Literature summary for 3.5.1.23 extracted from

  • Camacho, L.; Meca-Cortes, O.; Abad, J.L.; Garcia, S.; Rubio, N.; Diaz, A.; Celia-Terrassa, T.; Cingolani, F.; Bermudo, R.; Fernandez, P.L.; Blanco, J.; Delgado, A.; Casas, J.; Fabrias, G.; Thomson, T.M.
    Acid ceramidase as a therapeutic target in metastatic prostate cancer (2013), J. Lipid Res., 54, 1207-1220.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene ASAH1, expression analysis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(2E,4E)-N-[(2S,3R)-1,3-dihydroxyoctadecan-2-yl]hexa-2,4-dienamide
-
Homo sapiens
(E)-4-[(2S,3R)-N-1,3-dihydroxyoctadecan-2-ylamino]4-oxo-2-butenoic acid
-
Homo sapiens
(E)-N-[(2S,3R)-1,3-dihydroxyoctadecan-2-yl]but-2-enamide
-
Homo sapiens
N-[(2S 3R)-1,3-dihydroxyoctadecan-2-yl]3-methyl-2-butenamide.
-
Homo sapiens
N-[(2S,3R)-1,3-dihydroxyoctadecan-2-yl]2,2-dibromoacetamide strong inhibition Homo sapiens
N-[(2S,3R)-1,3-dihydroxyoctadecan-2-yl]2-bromoacetamide strong inhibition Homo sapiens
N-[(2S,3R)-1,3-dihydroxyoctadecan-2-yl]2-methylacrylamide strong inhibition Homo sapiens
N-[(2S,3R)-1,3-dihydroxyoctadecan-2-yl]acrylamide
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q13510 gene ASAH1
-

Source Tissue

Source Tissue Comment Organism Textmining
PC-3 cell high enzyme level, increased expression of acid ceramidase in highly metastatic clones derived from PC-3 prostate cancer cells. The highly aggressive and metastatic PC-3/Mc cells display levels of acid ceramidase activity that are 2.5 to 4times higher than those of PC-3/S cells Homo sapiens
-
prostate cancer cell high enzyme level Homo sapiens
-

Synonyms

Synonyms Comment Organism
acid ceramidase
-
Homo sapiens
ASAH1
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4.5
-
assay at Homo sapiens

General Information

General Information Comment Organism
malfunction ASAH1-knockdown PC-3/Mc cells show impairment of ceramide catabolism with increased sphingosine levels, sphingolipid content, overview. ASAH1 knockdown by shRNA inhibits the growth of PC-3/Mc cells under low-density and low-serum conditions and abrogates their anchorage-independent colony-forming potential Homo sapiens
metabolism acid ceramidase catalyzes the hydrolysis of ceramide into sphingosine, in turn a substrate of sphingosine kinases that catalyze its conversion into the mitogenic sphingosine 1-phosphate Homo sapiens