Literature summary for 3.5.1.23 extracted from

Mahdy, A.E.; Cheng, J.C.; Li, J.; Elojeimy, S.; Meacham, W.D.; Turner, L.S.; Bai, A.; Gault, C.R.; McPherson, A.S.; Garcia, N.; Beckham, T.H.; Saad, A.; Bielawska, A.; Bielawski, J.; Hannun, Y.A.; Keane, T.E.; Taha, M.I.; Hammouda, H.M.; Norris, J.S.; Liu, X.
Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer (2009), Mol. Ther., 17, 430-438.

Search for more literature for 3.5.1.23

Activating Compound

Activating Compound	Comment	Organism	Structure
radiation	-	Homo sapiens

Application

Application	Comment	Organism
medicine	downregulation of acid ceramidase increases sensitivity to radiation	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
LCL385	-	Homo sapiens
siRNA	-	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
lysosome	-	Homo sapiens	5764	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	acid ceramidase deacylates ceramide and yields sphingosine	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
PPC-1 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	acid ceramidase deacylates ceramide and yields sphingosine	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
acid ceramidase	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)