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Literature summary for 3.5.1.23 extracted from

  • Cheng, J.; Bai, A.; Beckham, T.; Tucker Marrison, S.; Yount, C.; Young, K.; Lu, P.; Bartlett, A.; Wu, B.; Keane, B.; Armeson, K.; Marshall, D.; Keane, T.; Smith, M.; Ellen Jones, E.; Drake Jr., R.; Bielawska, A.; Norris, J.; Liu, X.
    Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse (2013), J. Clin. Invest., 123, 4344-4358.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
radiation-induced acid ceramidase gene transactivation by activator protein 1 binding on the proximal promoter is sensitive to inhibition of de novo ceramide biosynthesis, as demonstrated by promoter reporter and ChIP-qPCR analyses Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
LCL521 a lysosomotropic prodrug inhibitor of acid ceramidase, inhibition in vivo leads to decreased cell viability Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q13510
-
-

Source Tissue

Source Tissue Comment Organism Textmining
22Rv1 cell
-
Homo sapiens
-
DU-145 cell
-
Homo sapiens
-
PPC-1 cell
-
Homo sapiens
-
prostate cancer cell line
-
Homo sapiens
-
WPMY-1 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-hexanoyl-sphingosine + H2O
-
Homo sapiens hexanoate + sphingosine
-
?

Synonyms

Synonyms Comment Organism
acid ceramidase
-
Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4.5
-
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens ionizing radiation selectively upregulates acid ceramidase in prostate cancer PCa cells, no induction of neutral and alkaline ceraamidases. Radiation-induced acid ceramidase gene transactivation by activator protein 1 binding on the proximal promoter is sensitive to inhibition of de novo ceramide biosynthesis, as demonstrated by promoter reporter and ChIP-qPCR analyses up

General Information

General Information Comment Organism
physiological function the influence of sphingolipids, such as ceramide and its metabolite sphingosine 1-phosphate, on signal transduction pathways under cell stress is important to survival adaptation responses. A protective feedback mechanism mitigates the apoptotic effect of ionizing radiation-induced ceramide generation. c-Jun-regulated acid veramidase mediates PCa cell radioresistance and relapse in vitro and in vivo Homo sapiens