Information on EC 3.4.23.16 - HIV-1 retropepsin

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The expected taxonomic range for this enzyme is: Human immunodeficiency virus 1

EC NUMBER
COMMENTARY hide
3.4.23.16
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RECOMMENDED NAME
GeneOntology No.
HIV-1 retropepsin
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
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CAS REGISTRY NUMBER
COMMENTARY hide
144114-21-6
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Automatic Mining of ENzyme DAta
animal
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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1181486 A+, 1214699 A+, 1214715 A+, 1214719 A+, 1214779 A+, 1214786 A+, 1214796 A+, 1214825 A+, 1214867 A+, 1214882 A+, 1214898 A+, 1214937 A+, 1214946 A+, 1214957 A+, 1214967 A+, 1214979 A+, 1214998 A+, 1215006 A+, 1215060 A+, 1215086 A+, 1215091 A+, 1215092 A+, 1215094 A+, 1215117 A+, 1215124 A+, 1215126 A+, 1215151 A+, 1215163 A+, 1215169 A+, 1215173 A+, 1215178 A+, 1215188 A+, 1215212 A+, 1215230 A+, 1215239 A+, 1215242 A+, 1215250 A+, 1215251 A+, 1215276 A+, 1215278 A+, 1215315 A+, 1215324 A+, 1215354 A+, 1215362 A+, 1215366 A+, 1215417 A+, 1215418 A+, 1215438 A+, 1215448 A+, 1215463 A+, 1215465 A+, 1215472 A+, 1215483 A+, 1215513 A+, 1215533 A+, 1215537 A+, 1215588 A+, 1215667 A+, 1215675 A+, 1215712 A+, 1215717 A+, 1215726 A+, 1215750 A+, 1215771 A+, 1215774 A+, 1215781 A+, 1215816 A+, 1215822 A+, 1215850 A+, 1270264 A+, 1271037 A+, 1271116 A+, 1271123 A+, 1271446 A+, 1272039 A+, 1272800 A+, 1273391 A+, 1273644 A+, 1274205 A+, 1274786 A+, 1275864 A+, 1276054 A+, 1276720 A+, 1277133 A+, 1277891 A+, 1279332 A+, 1279816 A+, 1281488 A+, 1282606 A+, 1282739 A+, 1537755 A+, 1555496 A+, 1560377 A+, 1560487 A+, 1561072 A+, 1562994 A+, 1563079 A+, 1564585 A+, 1564664 A+, 1564866 A+, 1565010 A+, 1958569 A+, 2006402 A+, 2006471 A+, 2065587 A+, 2065593 A+, 2065606 A+, 2065611 A+, 2065613 A+, 2065619 A+, 2065627 A+, 2065643 A+, 2065644 A+, 2065647 A+, 2065664 A+, 2105650 A+, 2105782 A+, 2106261 A+, 2107756 A+, 2218653 A+, 2252397 A+, 2421167 A+, 2422385 A+, 2423516 A+, 2424213 A+, 2424383 A+, 2425471 A+, 2469568 A+, 2502836 A+, 2570026 A+, 2618699 A+, 2650782 A+, 2658519 A+, 2692614 A+, 2877132 A+, 2877133 A+, 2999041 A+, 3015931 A+, 3025983 A+, 3093559 A+, 3093571 A+, 3093573 A+, 3093580 A+, 3093585 A+, 3093604 A+, 3093607 A+, 3093617 A+, 3093618 A+, 3093634 A+, 3093635 A+, 3093638 A+, 3093668 A+, 647859 A+, 698234 A+, 701086 A+, 707378 A+, 717185 A+, 734565 A+, 739560 A+, 743219 A+, 743357 A+, 745388 A+, 745409 A+, 745504 A+, 745882 A+, 746013 A+, 746172 A+, 746201 A+, 746305 A+, 746774 A+, 746926 A+, 747000 A+, 747024 A+, 747191 A+, 747332 A+, 747337 A+, 747505 A+, 747536 A+, 747577 A+, 747739 A+, 747762 A+, 747839 A+, 747924 A+, 748002 A+, 748150 A+, 748190 A+, 748259 A+, 748296 A+, 748371 A+, 748391 A+, 748558 A+, 748559 A+, 749135 A+, 749799 A+, 749850 A+, 750019 A+, 750182 A+, 750567 A+, 751034 A+, 751457 A+, 751460 A+, 823121 A+, 875426 A+, 877550 A+, 881011 A+, 902247 A+, 902878 A+, 902992 A+, 903157 A+, 903345 A+, 903429 A+, 961218 A+, 961385 A+, 961809 A+, 983798 A+, 1135881 A+++, 1214740 A+++, 1214926 A+++, 1214980 A+++, 1215007 A+++, 1215095 A+++, 1215114 A+++, 1215149 A+++, 1215168 A+++, 1215256 A+++, 1215304 A+++, 1215311 A+++, 1215343 A+++, 1215394 A+++, 743204 A+++, 746663 A+++, 903584 A+++, 904019 A+++, 979874 A+++
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Automatic Mining of ENzyme DAta
strain HXB2, produced in Escherichia coli
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Manually annotated by BRENDA team
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
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inactivation of HIV-1 protease significantly increases the protease-specific humoral immune responses in mice
physiological function
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the enzyme is required for virus replication
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-aminobenzoyl-Thr-Ile-Nle-p-nitro-Phe-Gln-Arg-NH2 + H2O
2-aminobenzoyl-Thr-Ile-Nle + p-nitro-Phe-Gln-Arg-NH2
show the reaction diagram
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?
2-aminobenzoyl-TI-Nle-Phe(NO2)-ER + H2O
2-aminobenzoyl-Thr-Ile-Nle + Phe(NO2)-Glu-Arg
show the reaction diagram
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?
2-aminobenzoyl-TI-Nle-Phe(NO2)-QR + H2O
2-aminobenzoyl-Thr-Ile-Nle + Phe(NO2)-Gln-Arg
show the reaction diagram
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?
2-aminobenzoyl-TI-Nle-Phe(NO2)-QR-NH2 + H2O
2-aminobenzoyl-Thr-Ile-Nle + Phe(NO2)-Gln-Arg-NH2
show the reaction diagram
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the enzyme reacts with the substrate to give an initial enzyme-substrate complex that isomerizes to a kinetically competent intermediate EX
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?
4-(4-(dimethylamino)phenylazo)benzoyl-SQNYPIVQ-5-((2-aminoethyl)amino)naphthalene-1-sulfonic acid + H2O
?
show the reaction diagram
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?
Abz-Ala-Arg-Val-Nle-(p-nitro)Phe-Phe-Glu-Ala-Nle-NH2 + H2O
Abz-Ala-Arg-Val-Nle + (p-nitro)Phe-Phe-Glu-Ala-Nle-NH2
show the reaction diagram
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?
Abz-Arg-Val-Nle-(p-nitro)Phe-Phe-Glu-Ala-Nle-NH2 + H2O
Abz-Arg-Val-Nle + (p-nitro)Phe-Phe-Glu-Ala-Nle-NH2
show the reaction diagram
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?
Abz-KARV-Nle-Phe(NO2)-EA-Nle-NH2 + H2O
Abz-KARV-Nle + Phe(NO2)-EA-Nle-NH2
show the reaction diagram
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?
Abz-Lys-Ala-Arg-Val-Nle-(p-nitro)Phe-Phe-Glu-Ala-Nle-NH2 + H2O
Abz-Lys-Ala-Arg-Val-Nle + (p-nitro)Phe-Phe-Glu-Ala-Nle-NH2
show the reaction diagram
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?
Abz-Thr-Ile-Nle-(p-nitro)Phe-Gln-Arg-NH2 + H2O
Abz-Thr-Ile-Nle + (p-nitro)Phe-Gln-Arg-NH2
show the reaction diagram
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?
Abz-Thr-Ile-Nle-4-nitro-Phe-Gln-Arg-NH2 + H2O
Abz-Thr-Ile-Nle + 4-nitro-Phe-Gln-Arg-NH2
show the reaction diagram
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the fluorogenic peptide substrate
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?
Abz-Thr-Ile-Nle-Phe(NO2)-Gln-Arg + H2O
Abz-Thr-Ile-Nle + Phe(NO2)-Gln-Arg
show the reaction diagram
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?
Abz-Thr-Nle-Phe(NO2)-QR-NH2 + H2O
Abz-Thr-Ile-Nle + Phe(NO2)-Gln-Arg-NH2
show the reaction diagram
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?
Ac-ARALAE-NH2 + H2O
Ac-ARAL + AE-NH2
show the reaction diagram
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?
Ac-ATIMMQR-NH2 + H2O
Ac-ATIM + MQR-NH2
show the reaction diagram
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?
Ac-HGWILAEHGD-NH2 + H2O
Ac-HGWIL + AEHGD-NH2
show the reaction diagram
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?
Ac-KASQ(p-nitrophenylalanine)PPV-NH2 + H2O
Ac-KASQ + (4-nitro)FPPV-NH2
show the reaction diagram
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?
Ac-RASQNYPVV-NH2 + H2O
Ac-RASQNY + PVV-NH2
show the reaction diagram
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?
Ac-RKILFLDG-NH2 + H2O
Ac-RKIL + FLDG-NH2
show the reaction diagram
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?
Ac-SQNYFLDG-NH2 + H2O
Ac-SQNY + FLDG-NH2
show the reaction diagram
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?
Ac-SQNYPIV-NH2 + H2O
Ac-SQNY + PIV-NH2
show the reaction diagram
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?
Ac-SQNYPVV-NH2 + H2O
Ac-SQNY + PVV-NH2
show the reaction diagram
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?
Ac-SQNYPVVR + H2O
Ac-SQNY + PVVR
show the reaction diagram
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?
Ac-SQSYPVV-NH2 + H2O
Ac-SQSY + PVV-NH2
show the reaction diagram
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?
Ac-TIMMQR-NH2 + H2O
Ac-TIM + MQR-NH2
show the reaction diagram
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?
Ac-VSQNYPIV-NH2 + H2O
Ac-VSQNY + PIV-NH2
show the reaction diagram
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?
Ac-YRARVFFVRAAK-biotin + H2O
?
show the reaction diagram
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?
AETFYVDG + H2O
?
show the reaction diagram
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?
AETFYVDGAA + H2O
AETF + YVDGAA
show the reaction diagram
Arg-Glu(EDANS)-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln Lys-(DABCYL)-Arg + H2O
?
show the reaction diagram
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?
Arg-Glu(EDANS)-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Lys(DABCYL)-Arg + H2O
?
show the reaction diagram
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?
Arg-Glu-[5-[(2'-aminoethyl)-amino]naphthalenesulfonyl]-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Lys-[4-[[4'-(dimethylamino)phenyl]azo]-benzoyl]-Arg + H2O
?
show the reaction diagram
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?
Arg-Pro-Gly-Asn-Phe-Leu-Gln-Ser-Arg-Pro + H2O
?
show the reaction diagram
decameric p1-p6 peptide
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?
ARVLAEAM + H2O
ARVL + AEAM
show the reaction diagram
ATHDVY-Phe(NO2)-VRKA + H2O
ATHDVY + Phe(NO2)-VRKA
show the reaction diagram
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?
ATHNVY-Phe(NO2)-VRKA + H2O
ATHNVY + Phe(NO2)-VRKA
show the reaction diagram
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?
ATHQVY-Phe(NO2)-VRKA + H2O
ATHQVY + Phe(NO2)-VRKA
show the reaction diagram
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?
ATHRVY-Phe(NO2)-VRKA + H2O
ATHRVY + Phe(NO2)-VRKA
show the reaction diagram
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?
ATHVVY-Phe(NO2)-VRKA + H2O
ATHVVY + Phe(NO2)-VRKA
show the reaction diagram
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?
ATHYVY-Phe(NO2)-VRKA + H2O
ATHYVY + Phe(NO2)-VRKA
show the reaction diagram
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?
ATIMMQRG + H2O
ATIM + MQRG
show the reaction diagram
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?
B-chain of oxidized insulin + H2O
?
show the reaction diagram
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?
beta-secretase + H2O
truncated beta-secretase protein + peptide E25-F39
show the reaction diagram
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expression of beta-secretase in mammalian host cells leads to full-length pro-form and the processed enzyme missing the first 24 amino acids and beginning with residue E25. Protease treatment of the mixture results in complete cleavage of the F39-V40 bond
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?
beta-secretase precursor protein + H2O
truncated beta-secretase protein + peptide T1-F39
show the reaction diagram
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expression of beta-secretase in mammalian host cells leads to full-length pro-form and the processed enzyme missing the first 24 amino acids and beginning with residue E25. Protease treatment of the mixture results in complete cleavage of the F39-V40 bond
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?
capsid-p2 protein + H2O
?
show the reaction diagram
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?
CTLNFPISP + H2O
CTLNF + PISP
show the reaction diagram
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?
DABCYL-(gamma-Abu)-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS + H2O
?
show the reaction diagram
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?
DTV(I)33EEMS + H2O
DTV(I)33 + EEMS
show the reaction diagram
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?
DTV(L)33EEMS + H2O
DTV(L)33 + EEMS
show the reaction diagram
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?
DTV(V)33EEMS + H2O
DTV(V)33 + EEMS
show the reaction diagram
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?
DTV(V)33EKMS + H2O
DTV(V)33 + EKMS
show the reaction diagram
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?
eIF4GI + H2O
?
show the reaction diagram
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perhaps cleavage of eIF4G is an event that contributes to a more efficient translation of the genomic HIV-1 mRNA, proteolysis of eIF4GI inhibits protein synthesis directed by capped mRNAs but allows internal ribosome entry site-driven translation, purified enzyme cleaves at positions 678-679, 681-682 and 1086-1087, separating the three domains of the initiation factor
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?
GAETFYVDGAA + H2O
GAETF + YVDGAA
show the reaction diagram
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-
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?
Gag polyprotein + H2O
?
show the reaction diagram
Gag precursor protein + H2O
?
show the reaction diagram
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five different cleavage sites, the p2-NC-site is the first, the CA/p2 the last one in sequential processing of the precursor
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?
Gag protein + H2O
?
show the reaction diagram
Gag-Pol polyprotein + H2O
?
show the reaction diagram
GagPol polyprotein + H2O
?
show the reaction diagram
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?
H-Lys-Ala-Arg-Val-Tyr-Phe(4-NO2)-Glu-Ala-Nle-NH2 + H2O
Lys-Ala-Arg-Val-Tyr + Phe(4-NO2)-Glu-Ala-Nle-NH2
show the reaction diagram
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?
His-Lys-Ala-Arg-Val-Leu-(4-nitro)Phe-Glu-Ala-Nle-Ser-amide + H2O
His-Lys-Ala-Arg-Val-Leu + (4-nitro)Phe-Glu-Ala-Nle-Ser-amide
show the reaction diagram
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-
-
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?
His-Lys-Ala-Arg-Val-Leu-(p-NO2-Phe)-Glu-Ala-Nle-Ser-NH2 + H2O
His-Lys-Ala-Arg-Val-Leu + (p-NO2-Phe)-Glu-Ala-Nle-Ser-NH2
show the reaction diagram
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-
-
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?
His-Lys-Ala-Arg-Val-Leu-(pNO2-Phe)-Glu-Ala-Ile-Ser-NH2 + H2O
His-Lys-Ala-Arg-Val-Leu + (pNO2-Phe)-Glu-Ala-Ile-Ser-NH2
show the reaction diagram
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-
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?
His-Lys-Ala-Arg-Val-Leu-(pNO2-Phe)-Glu-Ala-Nle-Ser-NH2 + H2O
?
show the reaction diagram
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-
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?
HIV-1 Gag-Pol polyprotein + H2O
?
show the reaction diagram
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site-specific proteolytic cleavage, protein precursors and peptides derived thereof
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?
HIV-2 Gag-Pol poylprotein + H2O
?
show the reaction diagram
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site-specific proteolytic cleavage, protein precursors and peptides derived thereof
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?
HKARVLAEAMS + H2O
HKARVL + AEAMS
show the reaction diagram
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-
-
?
IPFAAAQQRK + H2O
IPFAA + AQQRK
show the reaction diagram
the protein contains a HIV-2 cleavage site
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?
IRKILFLDG + H2O
IRKIL + FLDG
show the reaction diagram
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-
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?
KAQNYPIA-Nle + H2O
KAQNY + PIA-Nle
show the reaction diagram
-
-
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?
KAQNYPIV-Nle + H2O
KAQNY + PIV-Nle
show the reaction diagram
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-
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?
KARA-Nle-Phe(NO2)-EA-Nle + H2O
KARA-Nle + Phe(NO2)-EA-Nle
show the reaction diagram
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-
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?
KARI-Nle-Phe(NO2)-EA-Nle + H2O
KARI-Nle + Phe(NO2)-EA-Nle
show the reaction diagram
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-
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?
KARL-Nle-Phe(NO2)-EA-Nle + H2O
KARL-Nle + Phe(NO2)-EA-Nle
show the reaction diagram
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?
KARLMAEALK + H2O
KARLM + AEALK
show the reaction diagram
the protein contains a HIV-2 cleavage site
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?
KARN-Nle-Phe(NO2)-EA-Nle + H2O
KARN-Nle + Phe(NO2)-EA-Nle
show the reaction diagram
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?
KARNYPA-Nle + H2O
KARNY + PA-Nle
show the reaction diagram
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-
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?
KARNYPE-Nle + H2O
KARNY + PE-Nle
show the reaction diagram
-
-
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?
KARNYPI-Nle + H2O
KARNY + PI-Nle
show the reaction diagram
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-
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?
KARNYPN-Nle + H2O
KARNY + PN-Nle
show the reaction diagram
-
-
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?
KARNYPQ-Nle + H2O
KARNY + PQ-Nle
show the reaction diagram
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-
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?
KARNYPV-Nle + H2O
KARNY + PV-Nle
show the reaction diagram
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?
KARV-Nle-Phe(NO2)-AA-Nle + H2O
KARV-Nle + Phe(NO2)-AA-Nle
show the reaction diagram
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-
-
?
KARV-Nle-Phe(NO2)-EA-Nle + H2O
KARV-Nle + Phe(NO2)-EA-Nle
show the reaction diagram
KARV-Nle-Phe(NO2)-EA-Nle-NH2 + H2O
KARV-Nle + Phe(NO2)-EA-Nle-NH2
show the reaction diagram
KARV-Nle-Phe(NO2)-IA-Nle + H2O
KARV-Nle + Phe(NO2)-IA-Nle
show the reaction diagram
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-
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?
KARV-Nle-Phe(NO2)-NA-Nle + H2O
KARV-Nle + Phe(NO2)-NA-Nle
show the reaction diagram
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-
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?
KARV-Nle-Phe(NO2)-QA-Nle + H2O
KARV-Nle + Phe(NO2)-QA-Nle
show the reaction diagram
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-
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?
KARV-Nle-Phe(NO2)-TA-Nle + H2O
KARV-Nle + Phe(NO2)-TA-Nle
show the reaction diagram
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?
KARV-Nle-Phe(NO2)-VA-Nle + H2O
KARV-Nle + Phe(NO2)-VA-Nle
show the reaction diagram
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?
KARVL-Phe(NO2)-EAM + H2O
KARVL + Phe(NO2)-EAM
show the reaction diagram
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-
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?
KARVLAEAMS + H2O
KARVL + AEAMS
show the reaction diagram
KARVMPhe(NO2)-EA-Nle + H2O
KARVM + Phe(NO2)-EA-Nle
show the reaction diagram
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-
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?
KARVYPhe(NO2)-EA-Nle + H2O
KARVY + Phe(NO2)-EA-Nle
show the reaction diagram
-
-
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?
KGRPGNFLQSRP + H2O
KGRPGNF + LQSRP
show the reaction diagram
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-
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?
KLRPGNFLQSRP + H2O
KLRPGNF + LQSRP
show the reaction diagram
Lys-Ala-Arg-Val-Leu-4-nitro-Phe-Glu-Ala-Nle-Gly + H2O
Lys-Ala-Arg-Val-Leu + 4-nitro-Phe-Glu-Ala-Nle-Gly
show the reaction diagram
Lys-Ala-Arg-Val-Leu-Ala-Glu-Ala-Met + H2O
?
show the reaction diagram
-
in the protease-substrate complex the highest fluctuations correspond to the 17- and 39-turns and the substrate motion is anticorrelated with the 39-turn. The active site residues and the flap tips move in phase with the peptide
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?
Lys-Ala-Arg-Val-Leu-Phe(NO2)-Glu-Ala-Met + H2O
Lys-Ala-Arg-Val-Leu + Phe(NO2)-Glu-Ala-Met
show the reaction diagram
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-
-
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?
Lys-Ala-Arg-Val-Nle-(4-nitrophenylalanine)-Glu-Ala-Nle-NH2 + H2O
Lys-Ala-Arg-Val-Nle + (4-nitrophenylalanine)-Glu-Ala-Nle-NH2
show the reaction diagram
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-
-
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?
Lys-Ala-Arg-Val-Nle-(p-nitro-Phe)-Glu-Ala-Nle-amide + H2O
Lys-Ala-Arg-Val-Nle + (p-nitro-Phe)-Glu-Ala-Nle-amide
show the reaction diagram
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-
-
-
?
Lys-Ala-Arg-Val-Nle-4-nitro-Phe-Glu-Ala-Nle-amide + H2O
Lys-Ala-Arg-Val-Nle + 4-nitro-Phe-Glu-Ala-Nle-amide
show the reaction diagram
Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-Gly + H2O
Lys-Ala-Arg-Val-Nle + Phe(4-NO2)-Glu-Ala-Nle-Gly
show the reaction diagram
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-
-
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?
Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-NH2 + H2O
Lys-Ala-Arg-Val-Nle + Phe(4-NO2)-Glu-Ala-Nle-NH2
show the reaction diagram
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-
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?
Lys-Ala-Arg-Val-Tyr-p-nitro-Phe-Glu-Ala-Ile-NH2 + H2O
?
show the reaction diagram
-
-
-
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?
matrix-capsid protein + H2O
?
show the reaction diagram
-
-
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?
Moloney murine sarcoma virus-derived gag protein + H2O
?
show the reaction diagram
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-
-
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?
N-dansyl-SQNYPIV + H2O
?
show the reaction diagram
-
-
-
-
?
nucleocapsid protein + H2O
?
show the reaction diagram
nucleocapsid-p1 protein + H2O
?
show the reaction diagram
-
-
-
-
?
p1-p6 protein + H2O
?
show the reaction diagram
-
-
-
-
?
p2-nucleocapsid protein + H2O
?
show the reaction diagram
-
-
-
-
?
PAFVLAEAMR + H2O
PAFVL + AEAMR
show the reaction diagram
-
-
-
?
PARVLAEAMR + H2O
PARVL + AEAMR
show the reaction diagram
-
-
-
?
PARVLFEAMR + H2O
PARVL + FEAMR
show the reaction diagram
-
-
-
?
PARVLIEAMR + H2O
PARVL + IEAMR
show the reaction diagram
-
-
-
?
PARVLLEAMR + H2O
PARVL + LEAMR
show the reaction diagram
-
-
-
?
PARVLMEAMR + H2O
PARVL + MEAMR
show the reaction diagram
-
-
-
?
PARVLVEAMR + H2O
PARVL + VEAMR
show the reaction diagram
-
-
-
?
PFAVSLAMTMRR + H2O
PFAVS + LAMTMRR
show the reaction diagram
-
-
-
?
PGAVSLAMTMRR + H2O
PGAVS + LAMTMRR
show the reaction diagram
-
-
-
?
PGNFLESR + H2O
PGNF + LESR
show the reaction diagram
-
-
-
?
PHAVSLAMTMRR + H2O
PHAVS + LAMTMRR
show the reaction diagram
-
-
-
?
PLAVSLAMTMRR + H2O
PLAVS + LAMTMRR
show the reaction diagram
-
-
-
?
PNAVSLAMTMRR + H2O
PNAVS + LAMTMRR
show the reaction diagram
-
-
-
?
Pol polyprotein + H2O
?
show the reaction diagram
-
substrate sites, overview
-
-
?
Poly(A)-binding protein + H2O
?
show the reaction diagram
-
-
-
-
?
PPAGSLAMTMRR + H2O
PPAGS + LAMTMRR
show the reaction diagram
-
-
-
?
PPAHSLAMTMRR + H2O
PPAHS + LAMTMRR
show the reaction diagram
-
-
-
?
PPALSLAMTMRR + H2O
PPALS + LAMTMRR
show the reaction diagram
-
-
-
?
PPASSLAMTMRR + H2O
PPASS + LAMTMRR
show the reaction diagram
-
-
-
?
PPAVALAMTMRR + H2O
PPAVA + LAMTMRR
show the reaction diagram
-
-
-
?
PPAVELAMTMRR + H2O
PPAVE + LAMTMRR
show the reaction diagram
-
-
-
?
PPAVGLAMTMRR + H2O
PPAVG + LAMTMRR
show the reaction diagram
-
-
-
?
PPAVHLAMTMRR + H2O
PPAVH + LAMTMRR
show the reaction diagram
-
-
-
?
PPAVLLAMTMRR + H2O
PPAVL + LAMTMRR
show the reaction diagram
-
-
-
?
PPAVRLAMTMRR + H2O
PPAVR + LAMTMRR
show the reaction diagram
-
-
-
?
PPAVSEAMTMRR + H2O
PPAVS + EAMTMRR
show the reaction diagram
-
-
-
?
PPAVSFAMTMRR + H2O
PPAVS + FAMTMRR
show the reaction diagram
-
-
-
?
PPAVSGAMTMRR + H2O
PPAVS + GAMTMRR
show the reaction diagram
-
-
-
?
PPAVSLALTMRR + H2O
PPAVS + LALTMRR
show the reaction diagram
-
-
-
?
PPAVSLAMTMRR + H2O
PPAVS + LAMTMRR
show the reaction diagram
PPAVSLANTMRR + H2O
PPAVS + LANTMRR
show the reaction diagram
-
-
-
?
PPAVSLAYTMRR + H2O
PPAVS + LAYTMRR
show the reaction diagram
-
-
-
?
PPAVSLGMTMRR + H2O
PPAVS + LGMTMRR
show the reaction diagram
-
-
-
?
PPAVSLHMTMRR + H2O
PPAVS + LHMTMRR
show the reaction diagram
-
-
-
?
PPAVSLLMTMRR + H2O
PPAVS + LLMTMRR
show the reaction diagram
-
-
-
?
PPAVSLSMTMRR + H2O
PPAVS + LSMTMRR
show the reaction diagram
-
-
-
?
PPAVSQAMTMRR + H2O
PPAVS + QAMTMRR
show the reaction diagram
-
-
-
?
PPAVSRAMTMRR + H2O
PPAVS + RAMTMRR
show the reaction diagram
-
-
-
?
PPAVWLAMTMRR + H2O
PPAVW + LAMTMRR
show the reaction diagram
-
-
-
?
PPAWSLAMTMRR + H2O
PPAWS + LAMTMRR
show the reaction diagram
-
-
-
?
PPDVSLAMTMRR + H2O
PPDVS + LAMTMRR
show the reaction diagram
-
-
-
?
PPFVSLAMTMRR + H2O
PPFVS + LAMTMRR
show the reaction diagram
-
-
-
?
PPGVSLAMTMRR + H2O
PPGVS + LAMTMRR
show the reaction diagram
-
-
-
?
PPHVSLAMTMRR + H2O
PPHVS + LAMTMRR
show the reaction diagram
-
-
-
?
PPNVSLAMTMRR + H2O
PPNVS + LAMTMRR
show the reaction diagram
-
-
-
?
PPPVSLAMTMRR + H2O
PPPVS + LAMTMRR
show the reaction diagram
-
-
-
?
PPRVSLAMTMRR + H2O
PPRVS + LAMTMRR
show the reaction diagram
-
-
-
?
PQITLLLLLKWKRP + H2O
PQITLLLLL + WKRP
show the reaction diagram
-
-
-
?
PQITLLLLLWQRP + H2O
PQITLLLLL + WQRP
show the reaction diagram
-
-
-
?
reverse transcriptase-RNaseH protein + H2O
?
show the reaction diagram
-
-
-
-
?
REYDQI(I)63IEVS + H2O
REYDQI(I)63 + IEVS
show the reaction diagram
-
-
-
?
REYDQI(L)63IEVS + H2O
REYDQI(L)63 + IEVS
show the reaction diagram
-
-
-
?
REYDQI(L)63IKVS + H2O
REYDQI(L)63 + IKVS
show the reaction diagram
-
-
-
?
RKILFLDG + H2O
RKIL + FLDG
show the reaction diagram
-
-
-
?
RNaseH-integrase protein + H2O
?
show the reaction diagram
-
-
-
-
?
RQGTVSFNFPQITL + H2O
RQGTVSFNF + PQITL
show the reaction diagram
SANYPIV + H2O
SANY + PIV
show the reaction diagram
-
-
-
?
SCNYPIV + H2O
SCNY + PIV
show the reaction diagram
-
-
-
?
SDNYPIV + H2O
SDNY + PIV
show the reaction diagram
-
-
-
?
SENYPIV + H2O
SENY + PIV
show the reaction diagram
-
-
-
?
SFNFPQIT + H2O
SFNF + PQIT
show the reaction diagram
-
-
-
?
SFNYPIV + H2O
SFNY + PIV
show the reaction diagram
-
-
-
?
SGNYPIV + H2O
SGNY + PIV
show the reaction diagram
-
-
-
?
SHNYPIV + H2O
SHNY + PIV
show the reaction diagram
-
-
-
?
SINYPIV + H2O
SINY + PIV
show the reaction diagram
-
-
-
?
SKNYPIV + H2O
SKNY + PIV
show the reaction diagram
-
-
-
?
SLNYPIV + H2O
SLNY + PIV
show the reaction diagram
-
-
-
?
SMNYPIV + H2O
SMNY + PIV
show the reaction diagram
-
-
-
?
SNNYPIV + H2O
SNNY + PIV
show the reaction diagram
-
-
-
?
SQAYPIV + H2O
SQAY + PIV
show the reaction diagram
-
-
-
?
SQCYPIV + H2O
SQCY + PIV
show the reaction diagram
-
-
-
?
SQDYPIV + H2O
SQDY + PIV
show the reaction diagram
-
-
-
?
SQEYPIV + H2O
SQEY + PIV
show the reaction diagram
-
-
-
?
SQNFPIV + H2O
SQNF + PIV
show the reaction diagram
-
-
-
?
SQNLPIV + H2O
SQNL + PIV
show the reaction diagram
-
-
-
?
SQNMPIV + H2O
SQNM + PIV
show the reaction diagram
-
-
-
?
SQNWPIV + H2O
SQNW + PIV
show the reaction diagram
-
-
-
?
SQNYAIV + H2O
SQNY + AIV
show the reaction diagram
-
-
-
?
SQNYFIV + H2O
SQNY + FIV
show the reaction diagram
-
-
-
?
SQNYIIV + H2O
SQNY + IIV
show the reaction diagram
-
-
-
?
SQNYLIV + H2O
SQNY + LIV
show the reaction diagram
-
-
-
?
SQNYMIV + H2O
SQNY + MIV
show the reaction diagram
-
-
-
?
SQNYPAV + H2O
SQNY + PAV
show the reaction diagram
-
-
-
?
SQNYPIV + H2O
SQNY + PIV
show the reaction diagram
SQNYPIVQ + H2O
SQNY + PIVQ
show the reaction diagram
-
-
-
?
SQNYPLV + H2O
SQNY + PLV
show the reaction diagram
-
-
-
?
SQNYVIV + H2O
SQNY + VIV
show the reaction diagram
-
-
-
?
SQNYWIV + H2O
SQNY + WIV
show the reaction diagram
-
-
-
?
SQNYYIV + H2O
SQNY + YIV
show the reaction diagram
-
-
-
?
SQVYPIV + H2O
SQVY + PIV
show the reaction diagram
-
-
-
?
SRNYPIV + H2O
SRNY + PIV
show the reaction diagram
-
-
-
?
SSNYPIV + H2O
SSNY + PIV
show the reaction diagram
-
-
-
?
STNYPIV + H2O
STNY + PIV
show the reaction diagram
-
-
-
?
SWNYPIV + H2O
SWNY + PIV
show the reaction diagram
-
-
-
?
SYNYPIV + H2O
SYNY + PIV
show the reaction diagram
-
-
-
?
TATIMMQRGN + H2O
TATIM + MQRGN
show the reaction diagram
TFQA(p-nitrophenylalanine)PLREA + H2O
?
show the reaction diagram
-
-
-
-
?
TLNFPISP + H2O
TLNF + PISP
show the reaction diagram
-
-
-
?
TLNFPISPKK + H2O
TLNF + PISPKK
show the reaction diagram
-
-
-
-
?
translation initiation factor eIF4GI + H2O
?
show the reaction diagram
-
-
-
-
?
Val-Ser-Gln-Ala-Tyr-Pro-Ile-Val-Gln + H2O
Val-Ser-Gln-Ala-Tyr + Pro-Ile-Val-Gln
show the reaction diagram
-
-
-
?
Val-Ser-Gln-Asn-(2-naphthylalanine)-Pro-Ile-Val + H2O
?
show the reaction diagram
-
-
-
-
?
Val-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln + H2O
Val-Ser-Gln-Asn-Tyr + Pro-Ile-Val-Gln
show the reaction diagram
-
-
-
?
Val-Ser-Gln-Cys-Tyr-Pro-Ile-Val-Gln + H2O
Val-Ser-Gln-Cys-Tyr + Pro-Ile-Val-Gln
show the reaction diagram
-
-
-
?
Val-Ser-Gln-Gly-Tyr-Pro-Ile-Val-Gln + H2O
Val-Ser-Gln-Gly-Tyr + Pro-Ile-Val-Gln
show the reaction diagram
-
-
-
?
Val-Ser-Gln-Ile-Tyr-Pro-Ile-Val-Gln + H2O
Val-Ser-Gln-Ile-Tyr + Pro-Ile-Val-Gln
show the reaction diagram
-
-
-
?
Val-Ser-Gln-Leu-Tyr-Pro-Ile-Val-Gln + H2O
Val-Ser-Gln-Leu-Tyr + Pro-Ile-Val-Gln
show the reaction diagram
-
-
-
?
Val-Ser-Gln-Phe-Tyr-Pro-Ile-Val-Gln + H2O
Val-Ser-Gln-Phe-Tyr + Pro-Ile-Val-Gln
show the reaction diagram
-
-
-
?
Val-Ser-Gln-Thr-Tyr-Pro-Ile-Val-Gln + H2O
Val-Ser-Gln-Thr-Tyr + Pro-Ile-Val-Gln
show the reaction diagram
-
-
-
?
Val-Ser-Gln-Val-Tyr-Pro-Ile-Val-Gln + H2O
Val-Ser-Gln-Val-Tyr + Pro-Ile-Val-Gln
show the reaction diagram
-
-
-
?
VAQNYPIVQ + H2O
VAQNY + PIVQ
show the reaction diagram
-
-
-
?
VDQNYPIVQ + H2O
VDQNY + PIVQ
show the reaction diagram
-
-
-
?
VFQNYPIVQ + H2O
VFQNY + PIVQ
show the reaction diagram
-
-
-
?
VGQNYPIVQ + H2O
VGQNY + PIVQ
show the reaction diagram
-
-
-
?
VIQNYPIVQ + H2O
VIQNY + PIVQ
show the reaction diagram
-
-
-
?
VKQNYPIVQ + H2O
VKQNY + PIVQ
show the reaction diagram
-
-
-
?
VLQNYPIVQ + H2O
VLQNY + PIVQ
show the reaction diagram
VMQNYPIVQ + H2O
VMQNY + PIVQ
show the reaction diagram
-
-
-
?
VNQNYPIVQ + H2O
VNQNY + PIVQ
show the reaction diagram
-
-
-
?
VPQNYPIVQ + H2O
VPQNY + PIVQ
show the reaction diagram
-
-
-
?
VRQNYPIVQ + H2O
VRQNY + PIVQ
show the reaction diagram
-
-
-
?
VSFNFPQITKK + H2O
VSFNF + PQITKK
show the reaction diagram
-
-
-
?
VSFNFPQITL + H2O
VSFNF + PQITL
show the reaction diagram
-
-
?
VSQLYPIVQ + H2O
VSQLY + PIVQ
show the reaction diagram
the protein contains a HIV-1 cleavage site
-
-
?
VSQNYPIDQ + H2O
VSQNY + PIDQ
show the reaction diagram
-
-
-
?
VSQNYPIV + H2O
VSQNY + PIV
show the reaction diagram
-
-
-
?
VSQNYPIVQ + H2O
VSQNY + PIVQ
show the reaction diagram
VSQVYPIVQ + H2O
VSQVY + PIVQ
show the reaction diagram
the protein contains a HIV-1 cleavage site
-
-
?
VTQNYPIVQ + H2O
VTQNY + PIVQ
show the reaction diagram
-
-
-
?
VVQNYPIVQ + H2O
VVQNY + PIVQ
show the reaction diagram
YVSQNFPIVQNR + H2O
YVSQNF + PIVQNR
show the reaction diagram
-
synthetic peptide substrate based on the Ma/Ca cleavage site of HIV-1 Gag
-
-
?
elF4GI + H2O
additional information
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
eIF4GI + H2O
?
show the reaction diagram
-
perhaps cleavage of eIF4G is an event that contributes to a more efficient translation of the genomic HIV-1 mRNA, proteolysis of eIF4GI inhibits protein synthesis directed by capped mRNAs but allows internal ribosome entry site-driven translation, purified enzyme cleaves at positions 678-679, 681-682 and 1086-1087, separating the three domains of the initiation factor
-
-
?
Gag polyprotein + H2O
?
show the reaction diagram
Gag protein + H2O
?
show the reaction diagram
-
proteolytic cleavage in the host cell cytoplasm
-
-
?
Gag-Pol polyprotein + H2O
?
show the reaction diagram
GagPol polyprotein + H2O
?
show the reaction diagram
-
-
-
-
?
nucleocapsid protein + H2O
?
show the reaction diagram
-
-
-
-
?
Pol polyprotein + H2O
?
show the reaction diagram
-
substrate sites, overview
-
-
?
Poly(A)-binding protein + H2O
?
show the reaction diagram
-
-
-
-
?
translation initiation factor eIF4GI + H2O
?
show the reaction diagram
-
-
-
-
?
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Na+
-
role of Na+ ions in stabilizing the active site
NaCl
-
the protease works more efficiently at high salt concentrations, 2 M NaCl, than at lower salt concentrations
additional information
-
the activity of the enzyme is dependent on the ionic strength of the reaction mixture, rather than on the binding of a specific ion to an enzymatic site
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
((S)-1-(N'-(3',5'-difluoro-biphenyl-4-ylmethyl)-N'-[(S)-3-hydroxy-3-((1S,2R)-2-hydroxyindan-1-ylcarbamoyl)-4-phenyl-butyl]-hydrazinocarbonyl)-2,2-dimethyl-propyl)-carbamic acid methyl ester
-
-
((S)-1-(N'-(4'-acetylamino-biphenyl-4-ylmethyl)-N'-[(S)-3-hydroxy-3-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-4-phenyl-butyl]-hydrazinocarbonyl)-2,2-dimethylpropyl)-carbamic acid methyl ester
-
-
((S)-1-(N'-(4-benzo[1,3]dioxol-5-yl-benzyl)-N'-[(S)-3-hydroxy-3-((1S,2R)-2-hydroxyindan-1-ylcarbamoyl)-4-phenyl-butyl]-hydrazinocarbonyl)-2,2-dimethyl-propyl)-carbamic acid methyl ester
-
-
((S)-1-(N'-benzyl-N'-[(S)-3-hydroxy-3-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-4-phenyl-butyl]-hydrazinocarbonyl)-2,2-dimethyl-propyl)-carbamic acid methyl ester
-
-
((S)-1-(N'-[(S)-3-hydroxy-3-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-4-phenyl-butyl]-N'-phenethyl-hydrazinocarbonyl)-2,2-dimethyl-propyl)-carbamic acid methyl ester
-
-
((S)-1-(N'-[(S)-3-hydroxy-3-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-4-phenyl-butyl]-N'-[4-(1-methyl-1H-pyrazol-4-yl)-benzyl]-hydrazinocarbonyl)-2,2-dimethyl-propyl)-carbamic acid methyl ester
-
-
((S)-1-(N'-[4-(3,5-dimethyl-isoxazol-4-yl)-benzyl]-N'-[(S)-3-hydroxy-3-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-4-phenyl-butyl]-hydrazinocarbonyl)-2,2-dimethylpropyl)-carbamic acid methyl ester
-
-
((S)-1-[N'-(4-bromo-benzyl)-N'-[(S)-3-hydroxy-3-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-4-phenyl-butyl]-hydrazinocarbonyl]-2,2-dimethyl-propyl)-carbamic acid methyl ester
-
-
((S)-1-[N'-biphenyl-4-ylmethyl-N'-[(S)-3-hydroxy-3-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-4-phenyl-butyl]-hydrazinocarbonyl]-2,2-dimethyl-propyl)-carbamic acid methyl ester
-
-
((S)-1-[N'-[(S)-3-Hydroxy-3-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-4-phenyl-butyl]-N'-(4-pyridin-2-yl-benzyl)-hydrazinocarbonyl]-2,2-dimethyl-propyl)-carbamic acid methyl ester
-
-
((S)-1-[N'-[(S)-3-hydroxy-3-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-4-phenyl-butyl]-N'-(4-pyridin-3-yl-benzyl)-hydrazinocarbonyl]-2,2-dimethyl-propyl)-carbamic acid methyl ester
-
-
((S)-1-[N'-[(S)-3-hydroxy-3-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-4-phenyl-butyl]-N'-(4-pyridin-4-yl-benzyl)-hydrazinocarbonyl]-2,2-dimethyl-propyl)-carbamic acid methyl ester
-
-
(1-Benzyl-3-benzylcarbamoyl-3,3-difluoro-2-oxo-propyl)-carbamic acid benzyl ester
-
-
(1S)-1-[1-[(1S)-1-[1-[(1S)-1-[1-[(1S)-1-(1-[(2S)-1-[(2-ammonioethyl)amino]-1-oxo-3-phenylpropan-2-yl]-1H-1,2,3-triazol-4-yl)-2-phenylethyl]-1H-1,2,3-triazol-4-yl]-2-phenylethyl]-1H-1,2,3-triazol-4-yl]-2-phenylethyl]-1H-1,2,3-triazol-4-yl]-2-phenylethanamine
-
-
(1S)-1-[1-[(1S)-1-[1-[(1S)-1-[1-[(1S)-1-[1-[(2S)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl]-1H-1,2,3-triazol-4-yl]-2-phenylethyl]-1H-1,2,3-triazol-4-yl]-2-phenylethyl]-1H-1,2,3-triazol-4-yl]-2-phenylethyl]-1H-1,2,3-triazol-4-yl]-2-phenylethanaminium
-
-
(1S)-2-methyl-1-[1-[(1S)-1-[1-[(1S)-1-[1-[(1S)-2-methyl-1-[1-[(1R)-1-phenylethyl]-1H-1,2,3-triazol-4-yl]propyl]-1H-1,2,3-triazol-4-yl]-2-phenylethyl]-1H-1,2,3-triazol-4-yl]-2-phenylethyl]-1H-1,2,3-triazol-4-yl]propan-1-amine
-
-
(1S)-2-methyl-1-[1-[(1S)-2-methyl-1-[1-[(1S)-1-[1-[(1S)-2-methyl-1-[1-[(1R)-1-phenylethyl]-1H-1,2,3-triazol-4-yl]propyl]-1H-1,2,3-triazol-4-yl]-2-phenylethyl]-1H-1,2,3-triazol-4-yl]propyl]-1H-1,2,3-triazol-4-yl]propan-1-amine
-
-
(1S)-2-methyl-1-[1-[(1S)-2-phenyl-1-[1-[(1S)-2-phenyl-1-[1-[(1R)-1-phenylethyl]-1H-1,2,3-triazol-4-yl]ethyl]-1H-1,2,3-triazol-4-yl]ethyl]-1H-1,2,3-triazol-4-yl]propan-1-aminium
-
-
(1S)-2-phenyl-1-[1-[(1S)-2-phenyl-1-[1-[(1S)-2-phenyl-1-[1-[(1R)-1-phenylethyl]-1H-1,2,3-triazol-4-yl]ethyl]-1H-1,2,3-triazol-4-yl]ethyl]-1H-1,2,3-triazol-4-yl]ethanaminium
-
-
(1S)-2-phenyl-1-[1-[(1S)-2-phenyl-1-[1-[(1S)-2-phenyl-1-[1-[(1S)-2-phenyl-1-[1-[(1R)-1-phenylethyl]-1H-1,2,3-triazol-4-yl]ethyl]-1H-1,2,3-triazol-4-yl]ethyl]-1H-1,2,3-triazol-4-yl]ethyl]-1H-1,2,3-triazol-4-yl]ethanamine
-
-
(2E)-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[(thiophen-2-ylmethyl)[(2,4,5-trifluorophenyl)sulfonyl]amino]propyl]-4,4,4-trifluoro-3-methylbut-2-enamide
-
broad specificity against a clinically relevant panel of drug-resistant HIV-1 protease variants
(2E)-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[(thiophen-2-ylmethyl)[(2,4,5-trifluorophenyl)sulfonyl]amino]propyl]-4-oxopent-2-enamide
-
-
(2E)-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(5-methylisoxazol-4-yl)sulfonyl](thiophen-2-ylmethyl)amino]propyl]-4,4,4-trifluoro-3-methylbut-2-enamide
-
-
(2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(1R,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-oxopentyl]-N-tert-butyl-4-(pyridin-3-ylmethyl)piperazine-2-carboxamide
-
-
(2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(2R,5S)-2-hydroxy-5-methylcyclopentyl]amino]-5-oxopentyl]-N-tert-butyl-4-(3-pyridin-3-ylpropanoyl)piperazine-2-carboxamide
-
-
(2S)-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]propyl]-2-hydroxy-3-methylbutanamide
-
-
(2S)-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl](pentyl)amino]propyl]-2-hydroxy-3-methylbutanamide
-
-
(2S)-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino]propyl]-2-hydroxy-3-methylbutanamide
-
-
(2S)-N-[(1S,2R)-3-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-1-benzyl-2-hydroxypropyl]-2-hydroxy-3-methylbutanamide
-
-
(2S)-N-[(1S,2R)-3-[(1,3-benzothiazol-6-ylsulfonyl)(pentyl)amino]-1-benzyl-2-hydroxypropyl]-2,3-dimethylbutanamide
-
-
(2S)-N-[(1S,2R)-3-[(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino]-1-benzyl-2-hydroxypropyl]-2-hydroxy-3-methylbutanamide
-
broad specificity against a clinically relevant panel of drug-resistant HIV-1 protease variants
(2S)-N-[(1S,2R,3S,4S)-1-benzyl-2,3-dihydroxy-4-[[(2S)-3-methyl-2-[[methyl(pyridin-2-ylmethyl)carbamoyl]amino]butanoyl]amino]-5-phenylpentyl]-3-methyl-2-[[methyl(pyridin-2-ylmethyl)carbamoyl]amino]butanamide
-
-
(2S)-N-[(1S,2S,4S)-1-benzyl-2-hydroxy-4-[[(2S)-3-methyl-2-[[methyl(pyridin-2-ylmethyl)carbamoyl]amino]butanoyl]amino]-5-phenylpentyl]-3-methyl-2-[[methyl(pyridin-2-ylmethyl)carbamoyl]amino]butanamide
-
-
(2S)-N-[(2S,3R)-4-[(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino]-3-hydroxy-1-phenylbutan-2-yl]-2-hydroxy-3-methylbutanamide
-
-
(2S)-N-[(4S,7S,10S,11R,12R,13S)-10-benzyl-11,12-dihydroxy-4-(naphthalen-1-ylmethyl)-2,2-dioxido-5,8-dioxo-14-phenyl-7-(propan-2-yl)-2l6-thia-3,6,9-triazatetradecan-13-yl]-3-methyl-2-[[(2S)-2-[(methylsulfonyl)amino]-3-(naphthalen-1-yl)propanoyl]amino]butanamide)
-
-
(2S,2'S)-N,N'-[(2R,3R)-2,3-dihydroxybutane-1,4-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-3-methylbutanamide)
-
-
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-1,6-bis(1,3-benzodioxol-5-yl)-3,4-dihydroxyhexane-2,5-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-3-methylbutanamide)
-
-
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-1,6-bis(2,4-dimethoxyphenyl)-3,4-dihydroxyhexane-2,5-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-3-methylbutanamide)
-
-
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-bis(4-hydroxyphenyl)hexane-2,5-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-3-methylbutanamide)
-
-
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-3-methylbutanamide)
-
-
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(2-[[(2S)-2-benzyl-3-(tert-butylsulfonyl)propanoyl]amino]-3-methylbutanamide)
-
-
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(2-[[(2S)-2-hydroxy-3-phenylpropanoyl]amino]-3-methylbutanamide)
-
-
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(4-methoxybenzyl)propanoyl]amino]-3-methylbutanamide)
-
-
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-3,3-dimethylbutanamide)
-
-
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-3-methylbutanamide)
-
-
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]pentanamide)
-
-
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(2-[[3-(tert-butylsulfonyl)propanoyl]amino]-3-methylbutanamide)
-
-
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(3-methyl-2-[[(naphthalen-1-yloxy)acetyl]amino]butanamide)
-
-
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(3-methyl-2-[[3-(pyridin-4-ylsulfonyl)propanoyl]amino]butanamide)
-
-
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(3-methyl-2-[[methyl(pyridin-2-ylmethyl)carbamoyl]amino]butanamide)
-
-
(2S,2'S)-N,N'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis[2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-3-(1H-imidazol-4-yl)propanamide]
-
-
(2S,2'S)-N,N'-[(2S,3S,4S,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(3-methyl-2-[[methyl(pyridin-2-ylmethyl)carbamoyl]amino]butanamide)
-
-
(2S,2'S)-N,N'-[(3S,4R,5R,6S)-4,5-dihydroxy-1,8-di(pyridin-4-yl)octane-3,6-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-3-methylbutanamide)
-
-
(2S,2'S)-N,N'-[(3S,4R,5R,6S)-4,5-dihydroxy-1,8-diphenyloctane-3,6-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-3-methylbutanamide)
-
-
(2S,2'S)-N,N'-[(6S,7R,8R,9S)-7,8-dihydroxytetradecane-6,9-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]-3-methylbutanamide)
-
-
(2S,2'S)-N1,N1'-[(2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl]bis(2-[[(2S)-3-(tert-butylsulfonyl)-2-(naphthalen-1-ylmethyl)propanoyl]amino]butanediamide)
-
-
(2S,3S,4S,5S)-2,5-bis[N-[N-[[N-methyl-N-(2-pyridinylmethyl)amino]carbonyl]valinyl] amino]-1,6-dicyclohexylhexane-3,4-diol
-
compound has an improved response to V82A mutant enzyme
(2S,3S,4S,5S)-2,5-bis[N-[N-[[N-methyl-N-(2-pyridinylmethyl)amino]carbonyl]valinyl] amino]-1,6-diphenylhexane-3,4-diol
-
-
(2S,3S,4S,5S)-2,5-bis[N-[N-[[N-methyl-N-(2-pyridinylmethyl)amino]carbonyl]valinyl] amino]-6-cyclohexyl-1-phenylhexane-3,4-diol
-
compound has an improved response to V82A mutant enzyme
(2S,4S)-2-[(1R)-2-(benzylamino)-2-oxo-1-[(phenylacetyl)amino]ethyl]-N-[(1S)-1-hydroxy-2-phenylethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide
-
-
(2S,4S)-N-[(1R,2R)-4-[(1H-benzimidazol-2-ylmethyl)amino]-1-benzyl-2-hydroxy-4-oxobutyl]-2-[(1R)-1-(benzylcarbamoyl)-3-oxo-4-phenylbutyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide
-
-
(2Z)-4,4,4-trifluoro-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[(thiophen-2-ylmethyl)[(2,4,5-trifluorophenyl)sulfonyl]amino]butan-2-yl]-3-methylbut-2-enamide
-
-
(3aR,4R,7aS)-hexahydro-4H-furo[2,3-b]pyran-4-yl [(2S,3R)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}-1-phenylbutan-2-yl]carbamate
-
-
(3aR,5r,6aS)-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-5-yl [(2S,3S)-4-[(4R)-5,5-dimethyl-4-[(2-methylbenzyl)carbamoyl]-1,3-thiazolidin-3-yl]-3-hydroxy-4-oxo-1-phenylbutan-2-yl]carbamate
-
-
(3aR,7aR)-octahydro-1-benzofuran-4-yl [(2S,3R)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}-1-phenylbutan-2-yl]carbamate
-
-
(3aR,7aR)-octahydro-1H-inden-4-yl [(2S,3R)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}-1-phenylbutan-2-yl]carbamate
-
-
(3aS,4S,7aR)-hexahydro-4H-furo[2,3-b]pyran-4-yl [(2S,3R)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}-1-phenylbutan-2-yl]carbamate
-
-
(3aS,4S,7aR)-hexahydro-4H-furo[2,3-b]pyran-4-yl [(2S,3R)-4-{[(4-aminophenyl)sulfonyl](2-methylpropyl)amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate
-
-
(3aS,4S,7aR)-hexahydro-4H-furo[2,3-b]pyran-4-yl {(2S,3R)-3-hydroxy-4-[{[4-(hydroxymethyl)phenyl]sulfonyl}(2-methylpropyl)amino]-1-phenylbutan-2-yl}carbamate
-
-
(3aS,5R,6aR)-hexahydro-2H-cyclopenta[b]furan-5-yl [(2S,3S)-4-[(4R)-5,5-dimethyl-4-[(2-methylbenzyl)carbamoyl]-1,3-thiazolidin-3-yl]-3-hydroxy-4-oxo-1-phenylbutan-2-yl]carbamate
-
-
(3aS,5R,6aR)-hexahydro-2H-cyclopenta[b]furan-5-yl-(2S,3R)-3-hydroxy-4-(4-methoxy-N-(((R)-5-oxopyrrolidin-2-yl)methyl)phenylsulfonamido)-1-phenylbutan-2-ylcarbamate
-
-
(3aS,5R,6aR)-hexahydro-2H-cyclopenta[b]furan-5-yl-(2S,3R)-3-hydroxy-4-(4-methoxy-N-(((S)-5-oxopyrrolidin-2-yl)methyl)phenylsulfonamido)-1-phenylbutan-2-ylcarbamate
-
-
(3aS,5R,6aR)-hexahydro-2H-cyclopenta[b]furan-5-yl-(2S,3R)-4-(4-amino-N-(((R)-5-oxopyrrolidin-2-yl)methyl)phenylsulfonamido)-3-hydroxy-1-phenylbutan-2-ylcarbamate
-
-
(3aS,5R,7aR)-hexahydro-4H-furo[2,3-b]pyran-5-yl [(2S,3R)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}-1-phenylbutan-2-yl]carbamate
-
-
(3R)-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]propyl]-3-hydroxypentanamide
-
-
(3R)-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl](pentyl)amino]propyl]-3-hydroxypentanamide
-
-
(3R)-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino]propyl]-3-hydroxypentanamide
-
-
(3R)-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[[(5-methylisoxazol-4-yl)sulfonyl](thiophen-2-ylmethyl)amino]propyl]-3-methylpent-4-enamide
-
-
(3R)-N-[(1S,2R)-3-[(1,3-benzothiazol-6-ylsulfonyl)(2-methylpropyl)amino]-1-benzyl-2-hydroxypropyl]-3-hydroxypentanamide
-
-
(3R)-N-[(1S,2R)-3-[(1,3-benzothiazol-6-ylsulfonyl)(pentyl)amino]-1-benzyl-2-hydroxypropyl]-3-hydroxypentanamide
-
-
(3R)-N-[(1S,2R)-3-[(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino]-1-benzyl-2-hydroxypropyl]-3-hydroxypentanamide
-
-
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-3-hydroxy-4-(13-methoxy-1,1-dioxido-3,4,5,6,7,8,9,10-octahydro-2H-11,1,2-benzoxathiazacyclotridecin-2-yl)-1-phenylbutan-2-yl]carbamate
-
GRL-246
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-3-hydroxy-4-[(2-methylpropyl)([1-[2-(piperidin-1-yl)ethyl]-1H-benzimidazol-6-yl]sulfonyl)amino]-1-phenylbutan-2-yl]carbamate
-
-
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-3-hydroxy-4-[(7Z)-12-methoxy-1,1-dioxido-4,5,6,9-tetrahydro-10,1,2-benzoxathiazacyclododecin-2(3H)-yl]-1-phenylbutan-2-yl]carbamate
-
GRL-396
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-3-hydroxy-4-[(7Z)-13-methoxy-1,1-dioxido-3,4,5,6,9,10-hexahydro-2H-11,1,2-benzoxathiazacyclotridecin-2-yl]-1-phenylbutan-2-yl]carbamate
-
GRL-216, blocks dimerization
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-3-hydroxy-4-[(7Z)-14-methoxy-1,1-dioxido-4,5,6,9,10,11-hexahydro-12,1,2-benzoxathiazacyclotetradecin-2(3H)-yl]-1-phenylbutan-2-yl]carbamate
-
GRL-286, blocks dimerization
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-4-[(4R)-5,5-dimethyl-4-[(2-methylbenzyl)carbamoyl]-1,3-thiazolidin-3-yl]-3-hydroxy-1-phenylbutan-2-yl]carbamate
-
-
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3S)-3-hydroxy-4-[(4R)-4-[[4-(hydroxymethyl)-2-methylbenzyl]carbamoyl]-5,5-dimethyl-1,3-thiazolidin-3-yl]-4-oxo-1-phenylbutan-2-yl]carbamate
-
-
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3S)-4-[(4R)-4-[(4-amino-2-methylbenzyl)carbamoyl]-5,5-dimethyl-1,3-thiazolidin-3-yl]-3-hydroxy-4-oxo-1-phenylbutan-2-yl]carbamate
-
-
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3S)-4-[(4R)-5,5-dimethyl-4-[(2-methylbenzyl)carbamoyl]-1,3-thiazolidin-3-yl]-3-hydroxy-4-oxo-1-phenylbutan-2-yl]carbamate
-
-
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl(2S,3R)-3-hydroxy-4-(4-methoxy-N-(((S)-5-oxopyrrolidin-2-yl)methyl)phenylsulfonamido)-1-phenylbutan-2-yl-carbamate
-
-
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl(2S,3R)-4-(4-amino-N-(((S)-5-oxopyrrolidin-2-yl)methyl)phenylsulfonamido)-3-hydroxy-1-phenylbutan-2-ylcarbamate
-
-
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl-(2S,3R)-3-hydroxy-4-(4-methoxy-N-(((R)-2-oxooxazolidin-4-yl)methyl)phenylsulfonamido)-1-phenylbutan-2-ylcarbamate
-
-
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl-(2S,3R)-3-hydroxy-4-(4-methoxy-N-(((R)-5-oxopyrrolidin-2-yl)methyl)phenylsulfonamido)-1-phenylbutan-2-ylcarbamate
-
-
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl-(2S,3R)-3-hydroxy-4-(4-methoxy-N-(((S)-2-oxooxazolidin-4-yl)methyl)phenylsulfonamido)-1-phenylbutan-2-ylcarbamate
-
-
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl-(2S,3R)-4-(4-amino-N-(((R)-2-oxooxazolidin-4-yl)methyl)phenylsulfonamido)-3-hydroxy-1-phenylbutan-2-ylcarbamate
-
-
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl-(2S,3R)-4-(4-amino-N-(((R)-5-oxopyrrolidin-2-yl)methyl)phenylsulfonamido)-3-hydroxy-1-phenylbutan-2-ylcarbamate
-
-
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl-(2S,3R)-4-(4-amino-N-(((S)-2-oxooxazolidin-4-yl)methyl)phenylsulfonamido)-3-hydroxy-1-phenylbutan-2-ylcarbamate
-
-
(3R,4aR,8aR)-N-tert-butyl-2-[(2R,3R)-2-hydroxy-3-[[(3-hydroxy-2-methylphenyl)carbonyl]amino]-4-(phenylsulfanyl)butyl]decahydroisoquinoline-3-carboxamide
-
-
(3R,4aR,8aR)-N-tert-butyl-2-[(R)-2-hydroxy-3-(N-(2-phenylethyl)-4-aminophenylsulfonamido)propyl]decahydroisoquinoline-3-carboxamide
-
-
(3R,4aR,8aR)-N-tert-butyl-2-[(R)-2-hydroxy-3-(N-isobutyl-3-aminophenylsulfonamido)propyl]decahydroisoquinoline-3-carboxamide
-
-
(3R,4aR,8aR)-N-tert-butyl-2-[(R)-2-hydroxy-3-(N-isobutyl-4-aminophenylsulfonamido)propyl]decahydroisoquinoline-3-carboxamide
-
-
(3R,4aR,8aR)-N-tert-butyl-2-[(R)-2-hydroxy-3-(N-propyl-4-aminophenylsulfonamido)propyl]decahydroisoquinoline-3-carboxamide
-
-
(3R,4S,5S,6S)-2,7-dibenzyl-3,6-bis(phenoxymethyl)-1,2,7-thiadiazepane-4,5-diol 1,1-dioxide
-
-
(3R,6S,9S,10R,11R,12S,15S,18R)-3,9,12,18-tetrabenzyl-10,11-dihydroxy-4,7,14,17-tetraoxo-6,15-di(propan-2-yl)-5,8,13,16-tetraazaicosane-1,20-dioic acid
-
-
(3S)-tetrahydrofuran-3-yl [(2S,3R)-4-[(4R)-5,5-dimethyl-4-[(2-methylbenzyl)carbamoyl]-1,3-thiazolidin-3-yl]-3-hydroxy-1-phenylbutan-2-yl]carbamate
-
-
(3S)-tetrahydrofuran-3-yl [(2S,3S)-4-[(4R)-5,5-dimethyl-4-[(2-methylbenzyl)carbamoyl]-1,3-thiazolidin-3-yl]-3-hydroxy-4-oxo-1-phenylbutan-2-yl]carbamate
-
-
(3S,4aS,8aS)-2-((2R,3S)-4-(benzo[b]thiophen-2-yl)-2-hydroxy-3-(3-hydroxy-2-methylbenzamido)butyl)-N-tert-butyldecahydroisoquinoline-3-carboxamide
-
-
(3S,4aS,8aS)-N-tert-butyl-2-((2R,3R)-2-hydroxy-3-(3-hydroxy-2-methylbenzamido)-3-(4-phenylthiophen-2-yl)propyl)decahydroisoquinoline-3-carboxamide
-
-
(3S,4aS,8aS)-N-tert-butyl-2-((2R,3S)-2-hydroxy-3-(3-hydroxy-2-methylbenzamido)-4-(4-phenylthiophen-2-yl)butyl)decahydroisoquinoline-3-carboxamide
-
-
(3S,4aS,8aS)-N-tert-butyl-2-((2R,3S)-2-hydroxy-3-(3-hydroxy-2-methylbenzamido)-4-(thiophen-2-yl)butyl)decahydroisoquinoline-3-carboxamide
-
-
(3S,4aS,8aS)-N-tert-butyl-2-[(2R,3S)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(thiophen-2-yl)butyl]decahydroisoquinoline-3-carboxamide
-
-
(3S,4S)-3-((benzyl[(2-bromo-4,5-dimethoxyphenyl)carbonyl]amino)methyl)-4-(([2-(2,4-dichlorophenyl)ethyl](4-phenylbutanoyl)amino)methyl)pyrrolidinium
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IC50 is 0.0198 mM, binding structure analysis, modelling
(3S,4S)-3-((benzyl[(2-bromo-4,5-dimethoxyphenyl)carbonyl]amino)methyl)-4-(([2-(2,4-dichlorophenyl)ethyl][3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanoyl]amino)methyl)pyrrolidinium
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IC50 is 0.0221 mM, binding structure analysis, modelling
(4-[4-hydroxy-2-oxo-3-[(2-phenylethyl)sulfanyl]-2H-pyran-6-yl]phenoxy)acetic acid
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(4aR,7aS)-octahydrocyclopenta[b]pyran-4-yl [(2S,3R)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}-1-phenylbutan-2-yl]carbamate
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(4aS,7aR)-hexahydro-2H-furo[3,4-b]pyran-4-yl [(2S,3R)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}-1-phenylbutan-2-yl]carbamate
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(4R)-3-[(2S,3S)-2-hydroxy-3-[[(3-hydroxy-2-methylphenyl)carbonyl]amino]-4-phenylbutanoyl]-5,5-dimethyl-N-(2-methylbenzyl)-1,3-thiazolidine-4-carboxamide
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(4R)-4-([[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamoyl]oxy)-L-prolinamide
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(4R)-4-([[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamoyl]oxy)-N-(2,5-dimethoxyphenyl)-L-prolinamide
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(4R)-4-([[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamoyl]oxy)-N-(2-methoxyphenyl)-L-prolinamide
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(4R)-4-([[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamoyl]oxy)-N-(3,4,5-trimethoxyphenyl)-L-prolinamide
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(4R)-4-([[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamoyl]oxy)-N-(3-methoxyphenyl)-L-prolinamide
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(4R)-4-([[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamoyl]oxy)-N-(4-methoxyphenyl)-L-prolinamide
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(4R)-4-([[(2S,3R)-4-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamoyl]oxy)-N-(4-methylphenyl)-L-prolinamide