Literature summary for 3.4.23.16 extracted from

El Dine, R.S.; El Halawany, A.M.; Ma, C.M.; Hattori, M.
Inhibition of the dimerization and active site of HIV-1 protease by secondary metabolites from the Vietnamese mushroom Ganoderma colossum (2009), J. Nat. Prod., 72, 2019-2023.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli, commercial preparation	Human immunodeficiency virus 1

Inhibitors

Inhibitors	Comment	Organism	Structure
3-(4,8-dimethyl-3,7-nonadienyl)-(5R)-(2,5-dihydroxyphenyl)-2(5H)-furanone	ganomycin I	Human immunodeficiency virus 1
ganomycin B	competitive inhibition	Human immunodeficiency virus 1
pepstatin A	-	Human immunodeficiency virus 1
schisanlactone A	dimerization inhibitor	Human immunodeficiency virus 1
ursolic acid	dimerization inhibitor	Human immunodeficiency virus 1

Organism

Organism	UniProt	Comment	Textmining
Human immunodeficiency virus 1	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
His-Lys-Ala-Arg-Val-Leu-(p-NO2-Phe)-Glu-Ala-Nle-Ser-NH2 + H2O	-	Human immunodeficiency virus 1	His-Lys-Ala-Arg-Val-Leu + (p-NO2-Phe)-Glu-Ala-Nle-Ser-NH2	-	?

Synonyms

Synonyms	Comment	Organism
HIV-1 protease	-	Human immunodeficiency virus 1

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.004	-	ganomycin B	-	Human immunodeficiency virus 1

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
additional information	-	IC50: 0.001 mg/ml	Human immunodeficiency virus 1	pepstatin A
additional information	-	IC50: 0.001 mg/ml	Human immunodeficiency virus 1	ganomycin B
additional information	-	IC50: 0.005 mg/ml	Human immunodeficiency virus 1	schisanlactone A
additional information	-	IC50: 0.0075 mg/ml	Human immunodeficiency virus 1	3-(4,8-dimethyl-3,7-nonadienyl)-(5R)-(2,5-dihydroxyphenyl)-2(5H)-furanone

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Release 2023.1 (January 2023)