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Literature summary for 3.4.23.16 extracted from

  • Miura, T.; Brockman, M.A.; Brumme, Z.L.; Brumme, C.J.; Pereyra, F.; Trocha, A.; Block, B.L.; Schneidewind, A.; Allen, T.M.; Heckerman, D.; Walker, B.D.
    HLA-associated alterations in replication capacity of chimeric NL4-3 viruses carrying gag-protease from elite controllers of human immunodeficiency virus type 1 (2009), J. Virol., 83, 140-149.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine construction of chimeric viruses using patient-derived gag-protease sequences amplified from plasma HIV RNA and inserted into an NL4-3 backbone. The chimeric viruses generated from elite controllers display lower replication capacity than viruses from chronic progressors. Human leukocyte antigen system allele HLA-B*57 is associated with lower replication capacity than other alleles in both elite controllers and chronic progressor groups. Chimeric viruses from allele B*57 elite controllers demonstrate lower replication capacity than viruses from allele B*57 chronic progressors. Cytotoxic T-lymphocyte selection pressure on gag-protease alters virus replication capacity, and HIV-specific cytotoxic T-lymphocytes inducing escape mutations with fitness costs in this region may be important for strict viremia control in elite controllers of HIV Human immunodeficiency virus 1

Cloned(Commentary)

Cloned (Comment) Organism
amplified from blood plasma HIV RNA Human immunodeficiency virus 1

Protein Variants

Protein Variants Comment Organism
additional information construction of chimeric viruses using patient-derived gag-protease sequences amplified from plasma HIV RNA and inserted into an NL4-3 backbone. The chimeric viruses generated from elite controllers display lower replication capacity than viruses from chronic progressors. Human leukocyte antigen system allele HLA-B*57 is associated with lower replication capacity than other alleles in both elite controllers and chronic progressor groups. Chimeric viruses from allele B*57 elite controllers demonstrate lower replication capacity than viruses from allele B*57 chronic progressors. Cytotoxic T-lymphocyte selection pressure on gag-protease alters virus replication capacity, and HIV-specific cytotoxic T-lymphocytes inducing escape mutations with fitness costs in this region may be important for strict viremia control in elite controllers of HIV Human immunodeficiency virus 1

Organism

Organism UniProt Comment Textmining
Human immunodeficiency virus 1
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