Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,6-dimethylphenoxyacetyl-Phe-PSI(S,R,S)[OH]-Phe-2,6-dimethylphenoxyacetyl | IC50: 25 nM | Human immunodeficiency virus 1 | |
2,6-dimethylphenoxyacetyl-Phe-PSI(S,S,S)[OH]-Phe-2,6-dimethylphenoxyacetyl | IC50: 28 nM | Human immunodeficiency virus 1 | |
2-hydroxyphenoxyacetyl-Phe-PSI(S,R,S)[OH]-Phe-2-hydroxyphenoxyacetyl | IC50: 0.009 mM | Human immunodeficiency virus 1 | |
2-hydroxyphenoxyacetyl-Phe-PSI(S,S,S)[OH]-Phe-2-hydroxyphenoxyacetyl | IC50: 0.007 mM | Human immunodeficiency virus 1 | |
4-acetylphenoxyacetyl-Phe-PSI(S,R,S)[OH]-Phe-4-acetylphenoxyacetyl | IC50: 0.023 mM | Human immunodeficiency virus 1 | |
4-acetylphenoxyacetyl-Phe-PSI(S,S,S)[OH]-Phe-4-acetylphenoxyacetyl | IC50: 0.019 mM | Human immunodeficiency virus 1 | |
4-formylphenoxyacetyl-Phe-PSI(S,R,S)[OH]-Phe-4-acetylphenoxyacetyl | IC50: 0.08 mM | Human immunodeficiency virus 1 | |
4-formylphenoxyacetyl-Phe-PSI(S,S,S)[OH]-Phe-4-acetylphenoxyacetyl | IC50: 0.068 mM | Human immunodeficiency virus 1 | |
indinavir | IC50: 1.3 nM | Human immunodeficiency virus 1 | |
Kyn-(D-alpha-(2-thienyl)glycine)-Phe-PSI(S,R,S)[OH]-Phe-2,6-dimethylphenoxyacetyl | IC50: 3 nM | Human immunodeficiency virus 1 | |
Kyn-Thr-Phe-PSI(S,R,S)[OH]-Phe-2,6-dimethylphenoxyacetyl | IC50: 4 nM | Human immunodeficiency virus 1 | |
Kyn-Val-Phe-PSI(S,R,S)[OH]-Phe-2,6-dimethylphenoxyacetyl | IC50: 3 nM | Human immunodeficiency virus 1 | |
Kyn-Val-Phe-PSI(S,R,S)[OH]-Phe-Val-Kyn | IC50: 4 nM | Human immunodeficiency virus 1 | |
Kyn-Val-Phe-PSI(S,S,S)[OH]-Phe-2,6-dimethylphenoxyacetyl | IC50: 3 nM | Human immunodeficiency virus 1 | |
nelfinavir | IC50: 1.9 nM | Human immunodeficiency virus 1 | |
phenoxyacetyl-Phe-PSI(S,R,S)[OH]-Phe-phenoxyacetyl | IC50: 0.017 mM | Human immunodeficiency virus 1 | |
phenoxyacetyl-Phe-PSI(S,S,S)[OH]-Phe-phenoxyacetyl | IC50: 0.005 mM | Human immunodeficiency virus 1 | |
ritonavir | IC50: 3 nM | Human immunodeficiency virus 1 |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Human immunodeficiency virus 1 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Abz-Thr-Nle-Phe(NO2)-QR-NH2 + H2O | - |
Human immunodeficiency virus 1 | Abz-Thr-Ile-Nle + Phe(NO2)-Gln-Arg-NH2 | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000013 | - |
IC50: 1.3 nM | Human immunodeficiency virus 1 | indinavir | |
0.0000019 | - |
IC50: 1.9 nM | Human immunodeficiency virus 1 | nelfinavir | |
0.000003 | - |
IC50: 3 nM | Human immunodeficiency virus 1 | ritonavir | |
0.000003 | - |
IC50: 3 nM | Human immunodeficiency virus 1 | Kyn-(D-alpha-(2-thienyl)glycine)-Phe-PSI(S,R,S)[OH]-Phe-2,6-dimethylphenoxyacetyl | |
0.000003 | - |
IC50: 3 nM | Human immunodeficiency virus 1 | Kyn-Val-Phe-PSI(S,R,S)[OH]-Phe-2,6-dimethylphenoxyacetyl | |
0.000003 | - |
IC50: 3 nM | Human immunodeficiency virus 1 | Kyn-Val-Phe-PSI(S,S,S)[OH]-Phe-2,6-dimethylphenoxyacetyl | |
0.000004 | - |
IC50: 4 nM | Human immunodeficiency virus 1 | Kyn-Thr-Phe-PSI(S,R,S)[OH]-Phe-2,6-dimethylphenoxyacetyl | |
0.000004 | - |
IC50: 4 nM | Human immunodeficiency virus 1 | Kyn-Val-Phe-PSI(S,R,S)[OH]-Phe-Val-Kyn | |
0.000025 | - |
IC50: 25 nM | Human immunodeficiency virus 1 | 2,6-dimethylphenoxyacetyl-Phe-PSI(S,R,S)[OH]-Phe-2,6-dimethylphenoxyacetyl | |
0.000028 | - |
IC50: 28 nM | Human immunodeficiency virus 1 | 2,6-dimethylphenoxyacetyl-Phe-PSI(S,S,S)[OH]-Phe-2,6-dimethylphenoxyacetyl | |
0.005 | - |
IC50: 0.005 mM | Human immunodeficiency virus 1 | phenoxyacetyl-Phe-PSI(S,S,S)[OH]-Phe-phenoxyacetyl | |
0.007 | - |
IC50: 0.007 mM | Human immunodeficiency virus 1 | 2-hydroxyphenoxyacetyl-Phe-PSI(S,S,S)[OH]-Phe-2-hydroxyphenoxyacetyl | |
0.009 | - |
IC50: 0.009 mM | Human immunodeficiency virus 1 | 2-hydroxyphenoxyacetyl-Phe-PSI(S,R,S)[OH]-Phe-2-hydroxyphenoxyacetyl | |
0.017 | - |
IC50: 0.017 mM | Human immunodeficiency virus 1 | phenoxyacetyl-Phe-PSI(S,R,S)[OH]-Phe-phenoxyacetyl | |
0.019 | - |
IC50: 0.019 mM | Human immunodeficiency virus 1 | 4-acetylphenoxyacetyl-Phe-PSI(S,S,S)[OH]-Phe-4-acetylphenoxyacetyl | |
0.023 | - |
IC50: 0.023 mM | Human immunodeficiency virus 1 | 4-acetylphenoxyacetyl-Phe-PSI(S,R,S)[OH]-Phe-4-acetylphenoxyacetyl | |
0.068 | - |
IC50: 0.068 mM | Human immunodeficiency virus 1 | 4-formylphenoxyacetyl-Phe-PSI(S,S,S)[OH]-Phe-4-acetylphenoxyacetyl | |
0.08 | - |
IC50: 0.08 mM | Human immunodeficiency virus 1 | 4-formylphenoxyacetyl-Phe-PSI(S,R,S)[OH]-Phe-4-acetylphenoxyacetyl |