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Literature summary for 3.4.23.16 extracted from

  • Hong, L.; Zhang, C.; Hartsuck, J.A.; Foundling, S.; Tang, J.
    X-ray crystallographic studies of the structure-function relationships of HIV-1 protease (1998), Adv. Exp. Med. Biol., 436, 59-63.
    View publication on PubMed
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Application

Application Comment Organism
medicine the enzyme is responsible for the processing of gag and gag-pol polyprotein precursors to produce structural proteins and enzymes for the mature virus. Hence it is essential for the maturation and infectivity of the virus and is thus a major target for the development of inhibitor drugs Human immunodeficiency virus 1

Crystallization (Commentary)

Crystallization (Comment) Organism
X-ray crystallographic structures of two mutant HIV-1 proteases, G48H and A28S, in complex with a peptidic inhibitor U-89360E Human immunodeficiency virus 1

Inhibitors

Inhibitors Comment Organism Structure
U-89360E
-
 Human immunodeficiency virus 1

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Human immunodeficiency virus 1 the enzyme is responsible for the processing of gag and gag-pol polyprotein precursors to produce structural proteins and enzymes for the mature virus ?
-
 ?

Organism

Organism UniProt Comment Textmining
Human immunodeficiency virus 1
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is responsible for the processing of gag and gag-pol polyprotein precursors to produce structural proteins and enzymes for the mature virus Human immunodeficiency virus 1 ?
-
 ?