Protein Variants | Comment | Organism |
---|---|---|
Q7K/L331I/L631I | mutant enzyme is highly resistant to autolysis, while retaining the physical properties, specificity, and susceptibility to inhibition of the wild-type enzyme | Human immunodeficiency virus 1 |
General Stability | Organism |
---|---|
wild-type enzyme and proteolysis-resistant mutant enzyme Q7K/L33I/L63I are stabilized at higher ionic strength, 1.0 M NaCl | Human immunodeficiency virus 1 |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Human immunodeficiency virus 1 | - |
- |
- |
pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|
5 | - |
greatest conformational stability at pH 5, wild-type enzyme and proteolysis-resistant mutant enzyme Q7K/L33I/L63I are are more stable at pH 5.0 than at pH 7.0, the mutant enzyme is slightly more stable than the wild-type enzyme | Human immunodeficiency virus 1 |
7 | - |
wild-type enzyme and proteolysis-resistant mutant enzyme Q7K/L33I/L63I are more stable at pH 5.0 than at pH 7.0, the mutant enzyme is slightly more stable than the wild-type enzyme | Human immunodeficiency virus 1 |