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Literature summary for 3.4.23.16 extracted from
- Closing of the flaps of HIV-1 protease induced by substrate binding: a model of a flap closing mechanism in retroviral aspartic proteases (2006), Biochemistry, 45, 6606-6614.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GagPol polyprotein + H2O | Human immunodeficiency virus 1 | - |
? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Human immunodeficiency virus 1 | - |
i.e. HIV-1 | - |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro | flap closing and conformational change mechanism induced by substrate binding in HIV-1 aspartic protease, flap conformations in the active site during the catalytic cycle, molecular dynamic simulations, overview | Human immunodeficiency virus 1 |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GagPol polyprotein + H2O | - |
Human immunodeficiency virus 1 | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HIV-1 protease | - |
Human immunodeficiency virus 1 |
| PR | - |
Human immunodeficiency virus 1 |
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Release 2023.1 (January 2023)
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