Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ac-RASQNY | product inhibition with Ac-SQNYPVV as substrate | Human immunodeficiency virus 1 | |
Ac-RKIL | product inhibition with Ac-RKILFLDG-NH2 as substrate | Human immunodeficiency virus 1 | |
Ac-SQNY | product inhibition with Ac-RASQNYPVV or Ac-SQNYFLDG-NH2 as substrate | Human immunodeficiency virus 1 | |
Phe-Leu-Asp-Gly | product inhibition with Ac-RKILFLDG-NH2 as substrate | Human immunodeficiency virus 1 | |
Phe-Leu-Asp-Gly-NH2 | product inhibition with Ac-SQNYFLDG-NH2 as substrate | Human immunodeficiency virus 1 |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.012 | - |
Ac-HGWILAEHGD-NH2 | pH 6.0, 37°C | Human immunodeficiency virus 1 | |
0.66 | - |
Ac-SQNYFLDG-NH2 | pH 6.0, 37°C | Human immunodeficiency virus 1 | |
1.5 | - |
Ac-SQSYPVV-NH2 | pH 6.0, 37°C | Human immunodeficiency virus 1 | |
2.1 | - |
Ac-RKILFLDG-NH2 | pH 6.0, 37°C | Human immunodeficiency virus 1 | |
3.9 | - |
Ac-RASQNYPVV-NH2 | pH 6.0, 37°C | Human immunodeficiency virus 1 | |
5.5 | - |
Ac-SQNYPVV-NH2 | pH 6.0, 37°C | Human immunodeficiency virus 1 |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | the activity of the enzyme is dependent on the ionic strength of the reaction mixture, rather than on the binding of a specific ion to an enzymatic site | Human immunodeficiency virus 1 |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Human immunodeficiency virus 1 | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro | the kinetic mechanism of HIV-1 protease is random, in which products bind to form both binary and ternary enzyme-product complexes, depending on the substrate used | Human immunodeficiency virus 1 |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Ac-HGWILAEHGD-NH2 + H2O | - |
Human immunodeficiency virus 1 | Ac-HGWIL + AEHGD-NH2 | - |
? | |
Ac-RASQNYPVV-NH2 + H2O | - |
Human immunodeficiency virus 1 | Ac-RASQNY + PVV-NH2 | - |
? | |
Ac-RKILFLDG-NH2 + H2O | - |
Human immunodeficiency virus 1 | Ac-RKIL + FLDG-NH2 | - |
? | |
Ac-SQNYFLDG-NH2 + H2O | - |
Human immunodeficiency virus 1 | Ac-SQNY + FLDG-NH2 | - |
? | |
Ac-SQNYPVV-NH2 + H2O | - |
Human immunodeficiency virus 1 | Ac-SQNY + PVV-NH2 | - |
? | |
Ac-SQSYPVV-NH2 + H2O | - |
Human immunodeficiency virus 1 | Ac-SQSY + PVV-NH2 | - |
? |