Information on EC 3.1.26.3 - ribonuclease III

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
3.1.26.3
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RECOMMENDED NAME
GeneOntology No.
ribonuclease III
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
Endonucleolytic cleavage to 5'-phosphomonoester
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric diester
hydrolysis of phosphoric ester
CAS REGISTRY NUMBER
COMMENTARY hide
78413-14-6
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
K12
SwissProt
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
Escherichia coli MG1655rnc
gene rnc
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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UniProt
Manually annotated by BRENDA team
gne rnc
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
Paramecium bursaria Chlorella virus-1
i.e. PBCV-1, gene a464r
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Manually annotated by BRENDA team
RBIV
UniProt
Manually annotated by BRENDA team
RBIV
UniProt
Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
serovar Typhimurium strain SL1344
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-
Manually annotated by BRENDA team
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-
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Manually annotated by BRENDA team
gene mc
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Manually annotated by BRENDA team
M1 serotype
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Manually annotated by BRENDA team
M1 serotype
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-
Manually annotated by BRENDA team
gene rnc
UniProt
Manually annotated by BRENDA team
gene rnc
UniProt
Manually annotated by BRENDA team
M145
UniProt
Manually annotated by BRENDA team
synthetic construct
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
malfunction
metabolism
physiological function
additional information
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
25S pre-rRNA + H2O
25S rRNA
show the reaction diagram
35S pre-rRNA + H2O
mature 35S rRNA
show the reaction diagram
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double-stranded RNA regions in the 3'external transcribed spacer capped by terminal AGNN tetraloops determine the cleavage specificity
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-
?
515 bp dsRNA + H2O
?
show the reaction diagram
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Dicer-2 substrate is synthetic 515 bp dsRNA
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?
Aa-[16S[micro-hp]RNA] + H2O
?
show the reaction diagram
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structures of the Aquifex pre-16S and pre-23S rRNA processing stems and corresponding hairpin substrates, overview
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-
?
double-stranded RNA + H2O
5'-phosphooligonucleotides
show the reaction diagram
double-stranded RNA + H2O
?
show the reaction diagram
ds-rRNA + H2O
mature ds-rRNA
show the reaction diagram
dsDNA + H2O
?
show the reaction diagram
dsRNA + H2O
?
show the reaction diagram
dsRNA + H2O
mature RNA
show the reaction diagram
dsRNA + H2O
processed RNA
show the reaction diagram
hairpin RNA R1.1 + H2O
?
show the reaction diagram
-
RNase III(E38A) cleaves at the primary site and remains bound to the RNA, thereby preventing cleavage at the secondary site
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?
mature 23S rRNA
23S pre-rRNA + H2O
show the reaction diagram
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-
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?
mRNA + H2O
mature mRNA
show the reaction diagram
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specific processing of several hairpin nemis+, i.e. Neisseria miniature insertion sequences, mini transcripts, enzyme/substrate interaction, substrate specificity, overview
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?
mRNA transcripts + H2O
5'-phosphooligonucleotides
show the reaction diagram
poly(A)-poly(U) + H2O
5'-phosphooligonucleotides
show the reaction diagram
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-
-
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?
poly(I C) + H2O
5'-phosphooligonucleotides
show the reaction diagram
-
-
-
-
?
pre-16S rRNA + H2O
mature 16S rRNA
show the reaction diagram
-
-
-
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?
pre-23S rRNA + H2O
mature 23S rRNA
show the reaction diagram
pre-5S rRNA + H2O
mature 5S rRNA
show the reaction diagram
-
-
-
-
?
pre-mRNA + H2O
mature mRNA
show the reaction diagram
pre-rRNA + H2O
mature rRNA
show the reaction diagram
pre-snoRNA + H2O
mature snoRNA
show the reaction diagram
pre-snRNA + H2O
mature snRNA
show the reaction diagram
premicro-RNA + H2O
mature micro-RNA
show the reaction diagram
synthetic construct
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RNase III treatment causes a preferential loss of RNA in the 50- to 100-nt region. After RNase III treatment, the ratio of pre- to mature micro-RNA is reduced for micro-RNAs such as hsa-let-7b and hsa-let-7g, in both conditioned medium and mesenchymal stem cells due to a decrease in premicro-RNA level coupled with a concomitant increase in mature micro-RNA level
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?
R1.1 RNA + H2O
2 fragment of R1.1 RNA
show the reaction diagram
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substrate is enzymatically synthesized based on the R1.1 processing signal, which is encoded in the phage T7 genetic early region between genes 1.0 and 1.1, 1 cleavage site
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?
R1.1 RNA + H2O
2 fragments of R1.1 RNA
show the reaction diagram
R1.1 RNA + H2O
?
show the reaction diagram
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?
R1.1 RNA + H2O
fragments of R1.1 RNA
show the reaction diagram
R1.1 RNA derivatives + H2O
fragments of R1.1 RNA
show the reaction diagram
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based on the R1.1 processing signal, which is encoded in the phage T7 genetic early region between genes 1.0 and 1.1, derivative R1.1[CL3B] is not cleaved and its binding to the enzyme leads to uncoupling of substrate recognition and cleavage
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?
ribosomal RNA + H2O
smaller precursor rRNA
show the reaction diagram
RNA precursor + H2O
mature RNA
show the reaction diagram
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phage lambda RNA, enzyme is involved in translation control
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?
RNA substituted with guanosine 5'-O-(1-thiotriphosphate) + H2O
5'-phosphooligonucleotides containing guanosine 5'-O-(1-thiotriphosphate)
show the reaction diagram
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cleavage specifity is not altered by modified RNA
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?
single-stranded RNA + H2O
5'-phosphooligonucleotides
show the reaction diagram
synthetic 25S rRNA 3' ETS cleavage site containing RNA + H2O
?
show the reaction diagram
-
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?
tRNA + H2O
5'-phosphooligonucleotides
show the reaction diagram
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
25S pre-rRNA + H2O
25S rRNA
show the reaction diagram
-
processing
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?
double-stranded RNA + H2O
5'-phosphooligonucleotides
show the reaction diagram
ds-rRNA + H2O
mature ds-rRNA
show the reaction diagram
dsRNA + H2O
?
show the reaction diagram
-
cleavage to short RNA pieces
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?
dsRNA + H2O
mature RNA
show the reaction diagram
dsRNA + H2O
processed RNA
show the reaction diagram
-
-
-
-
?
pre-16S rRNA + H2O
mature 16S rRNA
show the reaction diagram
-
-
-
-
?
pre-23S rRNA + H2O
mature 23S rRNA
show the reaction diagram
-
-
-
-
?
pre-5S rRNA + H2O
mature 5S rRNA
show the reaction diagram
-
-
-
-
?
pre-mRNA + H2O
mature mRNA
show the reaction diagram
-
enzyme regulates gene expression by controlling mRNA translation and stability
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?
pre-rRNA + H2O
mature rRNA
show the reaction diagram
pre-snoRNA + H2O
mature snoRNA
show the reaction diagram
pre-snRNA + H2O
mature snRNA
show the reaction diagram
additional information
?
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