Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-hydroxyisoquinoline-1,3-dione | inhibits cleavage of R1.1 RNA, IC50: 0.014 mM for Mg2+-supported reaction, 0.008 mM for Mn2+-suppoeted reaction, noncompetitive inhibition | Escherichia coli |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | divalent metal required, Mg2+ is the preffered species, evidennce for involvement of two Mg2+ ions in phosphodiester hydrolysis | Escherichia coli | |
Mn2+ | divalent metal required, Mn2+ can replace Mg2+ in activation | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
double-stranded RNA + H2O | R1.1 RNA | Escherichia coli | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
RNase III | - |
Escherichia coli |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.014 | - |
inhibits cleavage of R1.1 RNA, IC50: 0.014 mM for Mg2+-supported reaction, 0.008 mM for Mn2+-suppoeted reaction, noncompetitive inhibition | Escherichia coli | 2-hydroxyisoquinoline-1,3-dione |