Reference on EC 2.7.11.15 - beta-adrenergic-receptor kinase and Organism(s) Bos taurus and UniProt Accession P21146
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Benovic, J.L.
Purification and characterization of beta-adrenergic receptor kinase
Methods Enzymol.
200
351-362
1991
Bos taurus
Benovic, J.L.; DeBlasi, A.; Stone, W.C.; Caron, M.G.; Lefkowitz, R.J.
Beta-adrenergic receptor kinase: primary structure delineates a multigene family
Science
246
235-240
1989
Bos taurus, Bos taurus (P21146)
Chuang, T.T.; Sallese, M.; Ambrosini, G.; Parruti, G.; De Blasi, A.
High expression of beta-adrenergic receptor kinase in human peripheral blood leukocytes. Isoproterenol and platelet activating factor can induce kinase translocation
J. Biol. Chem.
267
6886-6892
1992
Bos taurus, Homo sapiens, Homo sapiens (P25098)
Benovic, J.L.; Onorato, J.J.; Arriza, J.L.; Stone, W.C.; Lohse, M.; Jenkins, N.A.; Gilbert, D.J.; Copeland, N.G.; Caron, M.G.; Lefkowitz, R.J.
Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family
J. Biol. Chem.
266
14939-14946
1991
Bos taurus (P26818), Bos taurus
Parruti, G.; Ambrosini, G.; Sallese, M.; De Blasi, A.
Molecular cloning, functional expression and mRNA analysis of human beta-adrenergic receptor kinase 2
Biochem. Biophys. Res. Commun.
190
475-481
1993
Bos taurus, Homo sapiens (P35626), Homo sapiens
Benovic, J.L.; Mayor, F.; Somers, R.L.; Caron, M.G.; Lefkowitz, R.J.
Light-dependent phosphorylation of rhodopsin by beta-adrenergic receptor kinase
Nature
321
869-872
1986
Bos taurus
Onorato, J.J.; Palczewski, K.; Regan, J.W.; Caron, M.G.; Lefkowitz, R.J.; Benovic, J.L.
Role of acidic amino acids in peptide substrates of the beta-adrenergic receptor kinase and rhodopsin kinase
Biochemistry
30
5118-5125
1991
Bos taurus
Benovic, J.L.; Regan, J.W.; Matsui, H.; Mayor, F.; Cotecchia, S.; Leeb-Lundberg, L.M.F.; Caron, M.G.; Lefkowitz, R.J.
Agonist-dependent phosphorylation of the alpha 2-adrenergic receptor by the beta-adrenergic receptor kinase
J. Biol. Chem.
262
17251-17253
1987
Bos taurus
Benovic, J.L.; Mayor, F.; Staniczewski, C.; Lefkowitz, R.J.; Caron, M.G.
Purification and characterization of the beta-adrenergic receptor kinase
J. Biol. Chem.
262
9026-9032
1987
Bos taurus
Benovic, J.L.; Stone, W.C.; Caron, M.G.; Lefkowitz, R.J.
Inhibition of the beta-adrenergic receptor kinase by polyanions
J. Biol. Chem.
264
6707-6710
1989
Bos taurus
Kwatra, M.M.; Benovic, J.L.; Caron, M.G.; Lefkowitz, R.J.; Hosey, M.M.
Phosphorylation of chick heart muscarinic cholinergic receptors by the beta-adrenergic receptor kinase
Biochemistry
28
4543-4547
1989
Bos taurus
Shlemann, P.; Hekman, M.; Buchen, C.; Elce, J.S.; Lohse, M.J.
Purification and functional characterization of beta-adrenergic receptor kinase expressed in insect cells
FEBS Lett.
324
59-62
1993
Bos taurus, Homo sapiens
Kim, C.M.; Dion, S.B.; Onorato, J.J.; Benovic, J.L.
Expression and characterization of two beta-adrenergic receptor kinase isoforms using the baculovirus expression system
Receptor
3
39-55
1993
Bos taurus
Chen, C.Y.; Dion, S.B.; Kim, C.M.; Benovic, J.L.
Beta-adrenergic receptor kinase. Agonist-dependent receptor binding promotes kinase activation
J. Biol. Chem.
268
7825-7831
1993
Bos taurus
Goldman, P.S.; DeMaggio, A.J.; Hoekstra, M.F.; Goodman, R.H.
The beta-adrenergic receptor kinase interacts with the amino terminus of the G protein beta subunit
Biochem. Biophys. Res. Commun.
240
425-429
1997
Bos taurus
Touhara, K.
Effects of mutations in pleckstrin homology domain on beta-adrenergic receptor kinase activity in intact cells
Biochem. Biophys. Res. Commun.
252
669-674
1998
Bos taurus
Moffett, S.; Rousseau, G.; Lagace, M.; Bouvier, M.
The palmitoylation state of the beta2-adrenergic receptor regulates the synergistic action of cyclic AMP-dependent protein kinase and beta-adrenergic receptor kinase involved in its phosphorylation and desensitization
J. Neurochem.
76
269-279
2001
Bos taurus
Murga, C.; Esteban, N.; Ruiz-Gomez, A.; Mayor, F.Jr.
The basal subcellular distribution of beta-adrenergic receptor kinase is independent of G-protein betagamma subunits
FEBS Lett.
409
24-28
1997
Bos taurus
Mller, S.; Straub, A.; Lohse, M.J.
Selectivity of beta-adrenergic receptor kinase 2 for G protein betagamma subunits
FEBS Lett.
401
25-29
1997
Bos taurus
Touhara, K.
Binding of multiple ligands to pleckstrin homology domain regulates membrane translocation and enzyme activity of beta-adrenergic receptor kinase
FEBS Lett.
417
243-248
1997
Bos taurus
Murga, C.; Ruiz-Gomez, A.; Garcia-Higuera, I.; Kim, C.M.; Benovic, J.L.; Mayor, F.Jr.
High affinity binding of beta-adrenergic receptor kinase to microsomal membranes. Modulation of the activity of bound kinase by heterotrimeric G protein activation
J. Biol. Chem.
271
985-994
1996
Bos taurus
Onorato, J.J.; Gillis, M.E.; Liu, Y.; Benovic, J.L.; Ruoho, A.E.
The beta-adrenergic receptor kinase (GRK2) is regulated by phospholipids
J. Biol. Chem.
270
21346-21353
1995
Bos taurus
Lodowski, D.T.; Barnhill, J.F.; Pitcher, J.A.; Capel, W.D.; Lefkowitz, R.J.; Tesmer, J.J.
Purification, crystallization and preliminary X-ray diffraction studies of a complex between G protein-coupled receptor kinase 2 and Gbeta1gamma2
Acta Crystallogr. Sect. D
59
936-939
2003
Bos taurus
Wang, L.; Liu, S.; Quarles, L.D.; Spurney, R.F.
Targeted overexpression of G protein-coupled receptor kinase-2 in osteoblasts promotes bone loss
Am. J. Physiol.
288
E826-834
2005
Bos taurus
Lodowski, D.T.; Barnhill, J.F.; Pyskadlo, R.M.; Ghirlando, R.; Sterne-Marr, R.; Tesmer, J.J.
The role of Gbetagamma and domain interfaces in the activation of G protein-coupled receptor kinase 2
Biochemistry
44
6958-6970
2005
Bos taurus (P21146)
Ghadessy, R.S.; Willets, J.M.; Kelly, E.
G protein-coupled receptor kinase 6 (GRK6) selectively regulates endogenous secretin receptor responsiveness in NG108-15 cells
Br. J. Pharmacol.
138
660-670
2003
Bos taurus
Luo, Z.; Akita, G.Y.; Date, T.; Treleaven, C.; Vincent, K.A.; Woodcock, D.; Cheng, S.H.; Gregory, R.J.; Jiang, C.
Adenovirus-mediated expression of beta-adrenergic receptor kinase C-terminus reduces intimal hyperplasia and luminal stenosis of arteriovenous polytetrafluoroethylene grafts in pigs
Circulation
111
1679-1684
2005
Bos taurus
Pao, C.S.; Benovic, J.L.
Structure/function analysis of alpha2A-adrenergic receptor interaction with G protein-coupled receptor kinase 2
J. Biol. Chem.
280
11052-11058
2005
Bos taurus
Kim, K.M.; Gainetdinov, R.R.; Laporte, S.A.; Caron, M.G.; Barak, L.S.
G protein-coupled receptor kinase regulates dopamine D3 receptor signaling by modulating the stability of a receptor-filamin-beta-arrestin complex. A case of autoreceptor regulation
J. Biol. Chem.
280
12774-12780
2005
Bos taurus
Wu, J.H.; Goswami, R.; Kim, L.K.; Miller, W.E.; Peppel, K.; Freedman, N.J.
The platelet-derived growth factor receptor-beta phosphorylates and activates G protein-coupled receptor kinase-2. A mechanism for feedback inhibition
J. Biol. Chem.
280
31027-31035
2005
Bos taurus
Kenski, D.M.; Zhang, C.; von Zastrow, M.; Shokat, K.M.
Chemical genetic engineering of G protein-coupled receptor kinase 2
J. Biol. Chem.
280
35051-35061
2005
Bos taurus
Jimenez-Sainz, M.C.; Murga, C.; Kavelaars, A.; Jurado-Pueyo, M.; Krakstad, B.F.; Heijnen, C.J.; Mayor, F.Jr.; Aragay, A.M.
G protein-coupled receptor kinase 2 negatively regulates chemokine signaling at a level downstream from G protein subunits
Mol. Biol. Cell
17
25-31
2006
Bos taurus, Mus musculus
Lodowski, D.T.; Pitcher, J.A.; Capel, W.D.; Lefkowitz, R.J.; Tesmer, J.J.
Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma
Science
300
1256-1262
2003
Bos taurus
Meloni, A.R.; Fralish, G.B.; Kelly, P.; Salahpour, A.; Chen, J.K.; Wechsler-Reya, R.J.; Lefkowitz, R.J.; Caron, M.G.
Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2
Mol. Cell. Biol.
26
7550-7560
2006
Bos taurus
Chen, M.; Sato, P.Y.; Chuprun, J.K.; Peroutka, R.J.; Otis, N.J.; Ibetti, J.; Pan, S.; Sheu, S.S.; Gao, E.; Koch, W.J.
Prodeath signaling of g protein-coupled receptor kinase 2 in cardiac myocytes after ischemic stress occurs via extracellular signal-regulated kinase-dependent heat shock protein 90-mediated mitochondrial targeting
Circ. Res.
112
1121-1134
2013
Bos taurus, Rattus norvegicus
Fernandez, N.; Gottardo, F.L.; Alonso, M.N.; Monczor, F.; Shayo, C.; Davio, C.
Roles of phosphorylation-dependent and -independent mechanisms in the regulation of histamine H2 receptor by G protein-coupled receptor kinase 2
J. Biol. Chem.
286
28697-28706
2011
Bos taurus
Waldschmidt, H.V.; Homan, K.T.; Cruz-Rodriguez, O.; Cato, M.C.; Waninger-Saroni, J.; Larimore, K.M.; Cannavo, A.; Song, J.; Cheung, J.Y.; Kirchhoff, P.D.; Koch, W.J.; Tesmer, J.J.; Larsen, S.D.
Structure-based design, synthesis, and biological evaluation of highly selective and potent G protein-coupled receptor kinase 2 inhibitors
J. Med. Chem.
59
3793-3807
2016
Bos taurus (P21146)
