Activating Compound | Comment | Organism | Structure |
---|---|---|---|
alpha2A-adrenergic receptor | epinephrine-activated alpha2A-adrenergic receptor activates GRK2, interaction with GRK2 via the second and third intracellular loop of the receptor, determination of regions required for specific interaction utilizing recombinant GST-tagged wild-type and several mutant alpha2A ARs, residues R225, R226, R218, K320, R322, and K358 are important, overview | Bos taurus |
Cloned (Comment) | Organism |
---|---|
expression of GRK2 in Spodoptera frugiperda Sf9 cells using the baculovirus infection system | Bos taurus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Bos taurus | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + alpha2A-adrenergic receptor | Bos taurus | - |
ADP + phosphorylated alpha2A-adrenergic receptor | - |
? | |
ATP + G protein-coupled receptor | Bos taurus | desensitization of agonist-activated receptor | ADP + phosphorylated G protein-coupled receptor | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | epinephrine-activated alpha2A-adrenergic receptor activates GRK2, interaction with GRK2 via the second and third intracellular loop of the receptor, determination of regions required for specific interaction and phosphorylation activity utilizing recombinant GST-tagged wild-type and several mutant alpha2A ARs, residues R225, R226, R218, K320, R322, and K358 are important, overview | Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
central nervous system | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + alpha2A-adrenergic receptor | - |
Bos taurus | ADP + phosphorylated alpha2A-adrenergic receptor | - |
? | |
ATP + alpha2A-adrenergic receptor | interaction with GRK2 via the second and third intracellular loop of the receptor, determination of regions required for specific interaction and phosphorylation activity utilizing recombinant GST-tagged wild-type and several mutant alpha2A AR substrates, residues R225, R226, R218, K320, R322, and K358 are important, overview | Bos taurus | ADP + phosphorylated alpha2A-adrenergic receptor | - |
? | |
ATP + G protein-coupled receptor | - |
Bos taurus | ADP + phosphorylated G protein-coupled receptor | - |
? | |
ATP + G protein-coupled receptor | desensitization of agonist-activated receptor | Bos taurus | ADP + phosphorylated G protein-coupled receptor | - |
? |
Synonyms | Comment | Organism |
---|---|---|
G protein-coupled receptor kinase 2 | - |
Bos taurus |
GRK2 | - |
Bos taurus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Bos taurus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Bos taurus |