Activating Compound | Comment | Organism | Structure |
---|---|---|---|
beta-arrestin2 | mediates GRK activity, forms a signaling complex with filamin and dopamine D3 receptor, interactions, overview | Bos taurus |
Cloned (Comment) | Organism |
---|---|
overexpression of GRK2 in HEK-293 cells and in COS-7 cells, co-expression with FLAG-tagged dopamine D3 receptor, and filamin A and/or beta-arrestin, recombinant beta-arrestin is accumulated in the plasma membrane in presence of GRK2 and absence of agonist | Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
quinpirole | inhibits GRK2 and GRK3 | Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + dopamine D3 receptor | Bos taurus | the receptor is activated by GRK2 and GRK3 phosphorylation involving beta-arrestins, GRK-mediated regulation of receptor-filamin complex stability and receptor-G protein signaling potential, GRK2 reduces the dopamine D3 receptor signaling, overview | ADP + phosphorylated dopamine D3 receptor | - |
? | |
additional information | Bos taurus | dopamine D3 receptor binds to G proteins, the coupling is regulated by the filamin expression level | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + dopamine D3 receptor | - |
Bos taurus | ADP + phosphorylated dopamine D3 receptor | - |
? | |
ATP + dopamine D3 receptor | the receptor is activated by GRK2 and GRK3 phosphorylation involving beta-arrestins, GRK-mediated regulation of receptor-filamin complex stability and receptor-G protein signaling potential, GRK2 reduces the dopamine D3 receptor signaling, overview | Bos taurus | ADP + phosphorylated dopamine D3 receptor | - |
? | |
additional information | dopamine D3 receptor binds to G proteins, the coupling is regulated by the filamin expression level | Bos taurus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
G protein-coupled receptor kinase 2 | - |
Bos taurus |
G protein-coupled receptor kinase 3 | - |
Bos taurus |
GRK2 | - |
Bos taurus |
GRK3 | - |
Bos taurus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Bos taurus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Bos taurus |