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Literature summary for 2.7.11.15 extracted from

  • Chen, M.; Sato, P.Y.; Chuprun, J.K.; Peroutka, R.J.; Otis, N.J.; Ibetti, J.; Pan, S.; Sheu, S.S.; Gao, E.; Koch, W.J.
    Prodeath signaling of g protein-coupled receptor kinase 2 in cardiac myocytes after ischemic stress occurs via extracellular signal-regulated kinase-dependent heat shock protein 90-mediated mitochondrial targeting (2013), Circ. Res., 112, 1121-1134.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
carboxyl-terminus is expressed as a Flag-tagged betaARKct (GRK2 amino acids 495-689) in HeLa and HEK293 cells Bos taurus

Protein Variants

Protein Variants Comment Organism
DELTA495-689 carboxyl-terminus is expressed as a Flag-tagged betaARKct (GRK2 amino acids 495-689) in HeLa and HEK293 cells Bos taurus
S670A cells overexpressing the S670A-GRK2 mutant have less H2O2-induced death as determined by the terminal deoxynucleotidyl transferase dUTP nick end labeling assay. In cells expressing mutant GRK2, the amount of cell death is significantly reduced by 36.4%. Mutant displays significantly less Hsp90 binding in myocytes after oxidative stress compared with wild-type GRK2. Nonphosphorylated mutant S670A is not localized to mitochondria after oxidative stress Bos taurus
S670D mutant shows the highest level of interaction with Hsp90 compared to wild-type and mutant S670A Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion after myocardial ischemic and oxidative stress there is increased mitochondrial GRK2 translocation Rattus norvegicus 5739
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mitochondrion after myocardial ischemic and oxidative stress there is increased mitochondrial GRK2 translocation Bos taurus 5739
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Bos taurus carboxyl-terminus of GRK2 interacts with Hsp90. Reactive oxygen species (ROS)-mediated mitochrondrial localisation of GRK2 is dependent on Hsp90 binding ?
-
?
additional information Rattus norvegicus GRK2 interacts with Hsp90. Reactive oxygen species (ROS)-mediated mitochrondrial localisation of GRK2 is dependent on Hsp90 binding ?
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein
-
Rattus norvegicus
phosphoprotein phosphorylated at Ser670 Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
myocyte
-
Rattus norvegicus
-
myocyte
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Bos taurus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information carboxyl-terminus of GRK2 interacts with Hsp90. Reactive oxygen species (ROS)-mediated mitochrondrial localisation of GRK2 is dependent on Hsp90 binding Bos taurus ?
-
?
additional information GRK2 interacts with Hsp90. Reactive oxygen species (ROS)-mediated mitochrondrial localisation of GRK2 is dependent on Hsp90 binding Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
bARKct
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Rattus norvegicus
bARKct
-
Bos taurus
carboxyl-terminus of beta-adrenergic receptor kinase
-
Rattus norvegicus
carboxyl-terminus of beta-adrenergic receptor kinase
-
Bos taurus
GRK2
-
Rattus norvegicus
GRK2
-
Bos taurus