Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Carbachol | requirement, agonist, muscarinic cholinergic receptor as substrate | Bos taurus | |
isoproterenol | requirement, beta-agonist, beta-adrenergic receptor as substrate | Bos taurus | |
additional information | agonists induce specific conformational changes allowing phosphorylation | Bos taurus | |
Oxytremorine | requirement, agonist, muscarinic cholinergic receptor as substrate | Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
atropine | receptor antagonist | Bos taurus | |
heparin | 0.001 mM, complete inhibition of muscarinic cholinergic receptor phosphorylation | Bos taurus | |
McN-A343 | weak, partial antagonist | Bos taurus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | requirement | Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + beta-adrenergic receptor | Bos taurus | agonist-occupied form of the receptor | ADP + phospho-beta-adrenergic receptor | - |
? | |
ATP + beta-adrenergic receptor | Bos taurus | involved in homologous desensitization of beta-adrenergic receptor | ADP + phospho-beta-adrenergic receptor | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | cerebral cortex | Bos taurus | - |
cerebral cortex | - |
Bos taurus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.05 | 0.08 | pH 7.5, 30°C | Bos taurus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + alpha2-adrenergic receptor | - |
Bos taurus | ADP + phospho-alpha2-adrenergic receptor | - |
? | |
ATP + beta-adrenergic receptor | beta2-adrenergic receptor | Bos taurus | ADP + phospho-beta-adrenergic receptor | - |
? | |
ATP + beta-adrenergic receptor | specifically phosphorylates the agonist-occupied form of the receptor | Bos taurus | ADP + phospho-beta-adrenergic receptor | - |
? | |
ATP + beta-adrenergic receptor | at a similar rate as muscarinic cholinergic receptor | Bos taurus | ADP + phospho-beta-adrenergic receptor | - |
? | |
ATP + beta-adrenergic receptor | agonist-occupied form of the receptor | Bos taurus | ADP + phospho-beta-adrenergic receptor | - |
? | |
ATP + beta-adrenergic receptor | involved in homologous desensitization of beta-adrenergic receptor | Bos taurus | ADP + phospho-beta-adrenergic receptor | - |
? | |
ATP + muscarinic cholinergic receptor | in vitro as good as beta-adrenergic receptor, phosphorylation depends on the presence of a muscarinic agonist ligand, not merely receptor occupancy, the agonist induces a conformational change, which allows phosphorylation, phosphorylation sites: 70% Ser- and 30% Thr-residues, incorporation of 3-4 mol phosphate/mol receptor | Bos taurus | ADP + phospho-muscarinic cholinergic receptor | - |
? | |
ATP + muscarinic cholinergic receptor | from chick heart | Bos taurus | ADP + phospho-muscarinic cholinergic receptor | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Bos taurus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Bos taurus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00015 | - |
heparin | - |
Bos taurus |