Any feedback?
Literature summary for 2.7.11.15 extracted from
- High expression of beta-adrenergic receptor kinase in human peripheral blood leukocytes. Isoproterenol and platelet activating factor can induce kinase translocation (1992), J. Biol. Chem., 267, 6886-6892.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| isoproterenol | requirement, beta-agonist, beta-adrenergic receptor as substrate | Homo sapiens |  |
| isoproterenol | requirement, beta-agonist, beta-adrenergic receptor as substrate | Bos taurus | |
| platelet activating factor | requirement, agonist, beta-adrenergic receptor as substrate | Homo sapiens | |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| cDNA encoding beta-ARK 1 is cloned and sequenced, very similar sequences of bovine and human kinases | Homo sapiens |
| cloning and sequencing | Homo sapiens |
| very similar cDNA sequences of bovine and human kinases | Bos taurus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| heparin | - |
Bos taurus | |
| heparin | rhodopsin phosphorylation, in a dose-dependent manner | Homo sapiens | |
| additional information | - |
Bos taurus | |
| additional information | not inhibited by protein kinase A inhibitor PKI; not inhibited by staurosporine | Homo sapiens | |
| Protein kinase C inhibitor H7 | weak | Bos taurus | |
| Protein kinase C inhibitor H7 | weak | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Bos taurus | 5829 | - |
| cytosol | cytosolic enzyme, isoproterenol and platelet-activating factor induce translocation of beta-ARK from cytosol to membrane | Homo sapiens | 5829 | - |
| membrane | - |
Bos taurus | 16020 | - |
| membrane | isoproterenol and platelet-activating factor induce translocation of beta-ARK from cytosol to membrane | Homo sapiens | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | requirement | Homo sapiens | |
| Mg2+ | requirement | Bos taurus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + beta-adrenergic receptor | Homo sapiens | presumably modulates some receptor-mediated immune functions | ADP + phospho-beta-adrenergic receptor | - |
? | |
| ATP + beta-adrenergic receptor | Homo sapiens | agonist-occupied form of the receptor | ADP + phospho-beta-adrenergic receptor | - |
? | |
| ATP + beta-adrenergic receptor | Bos taurus | agonist-occupied form of the receptor | ADP + phospho-beta-adrenergic receptor | - |
? | |
| ATP + beta-adrenergic receptor | Homo sapiens | involved in homologous desensitization of beta-adrenergic receptor | ADP + phospho-beta-adrenergic receptor | - |
? | |
| ATP + beta-adrenergic receptor | Bos taurus | involved in homologous desensitization of beta-adrenergic receptor | ADP + phospho-beta-adrenergic receptor | - |
? | |
| additional information | Homo sapiens | role for beta ARK in modulating some receptor-mediated immune functions | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
enzyme exists in 2 subtypes: beta-ARK 1 and beta-ARK 2 | - |
| Homo sapiens | - |
major isoform beta-ARK 1 | - |
| Homo sapiens | - |
enzyme exists in 2 subtypes: beta-ARK1 and 2 | - |
| Homo sapiens | P25098 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | moderate expression of beta-ARK 1 | Homo sapiens | - |
| HL-60 cell | high expression of beta-ARK 1 | Homo sapiens | - |
| IMR-32 cell | beta-ARK 1 | Homo sapiens | - |
| JURKAT cell | high expression of beta-ARK 1 | Homo sapiens | - |
| leukemia cell | myeloid and lymphoid leukemia cell lines, high expression of beta-ARK 1 | Homo sapiens | - |
| leukocyte | - |
Bos taurus | - |
| leukocyte | peripheral blood leukocytes | Homo sapiens | - |
| leukocyte | mononuclear, peripheral blood leukocytes, high expression | Homo sapiens | - |
| leukocyte | beta-ARK 1 | Homo sapiens | - |
| MOLT-4 cell | high expression of beta-ARK 1 | Homo sapiens | - |
| additional information | - |
Bos taurus | - |
| additional information | tissue distribution of beta-ARK 1 | Homo sapiens | - |
| U-937 cell | high expression of beta-ARK 1 | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + beta-adrenergic receptor | specifically phosphorylates the agonist-occupied form of the receptor | Homo sapiens | ADP + phospho-beta-adrenergic receptor | - |
? | |
| ATP + beta-adrenergic receptor | specifically phosphorylates the agonist-occupied form of the receptor | Bos taurus | ADP + phospho-beta-adrenergic receptor | - |
? | |
| ATP + beta-adrenergic receptor | presumably modulates some receptor-mediated immune functions | Homo sapiens | ADP + phospho-beta-adrenergic receptor | - |
? | |
| ATP + beta-adrenergic receptor | agonist-occupied form of the receptor | Homo sapiens | ADP + phospho-beta-adrenergic receptor | - |
? | |
| ATP + beta-adrenergic receptor | agonist-occupied form of the receptor | Bos taurus | ADP + phospho-beta-adrenergic receptor | - |
? | |
| ATP + beta-adrenergic receptor | involved in homologous desensitization of beta-adrenergic receptor | Homo sapiens | ADP + phospho-beta-adrenergic receptor | - |
? | |
| ATP + beta-adrenergic receptor | involved in homologous desensitization of beta-adrenergic receptor | Bos taurus | ADP + phospho-beta-adrenergic receptor | - |
? | |
| ATP + platelet-activating factor receptor | PAF receptor acts as substrate | Homo sapiens | ADP + phospho-platelet-activating factor receptor | - |
? | |
| ATP + rhodopsin | light-dependent, actual substrate: light-bleached rhodopsin | Homo sapiens | ADP + phosphorhodopsin | - |
? | |
| ATP + rhodopsin | light-dependent, actual substrate: light-bleached rhodopsin | Bos taurus | ADP + phosphorhodopsin | - |
? | |
| ATP + rhodopsin | in form of bovine rod outer segments | Homo sapiens | ADP + phosphorhodopsin | - |
? | |
| ATP + rhodopsin | in form of bovine rod outer segments | Bos taurus | ADP + phosphorhodopsin | - |
? | |
| additional information | role for beta ARK in modulating some receptor-mediated immune functions | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ark | - |
Homo sapiens |
| beta-adrenergic receptor kinase 1 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Homo sapiens |
| 30 | - |
assay at | Bos taurus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
| 7.4 | - |
assay at | Bos taurus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
| ATP | - |
Bos taurus | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
