Activating Compound | Comment | Organism | Structure |
---|---|---|---|
G protein | GRK2 binds G protein beta1gamma2 subunits, binding structure, overview | Bos taurus |
Cloned (Comment) | Organism |
---|---|
co-overexpression of GRK2 and G protein beta1gamma2 subunits in Spodoptera frugiperda Sf9 cells using the baculovirus infection system | Bos taurus |
Crystallization (Comment) | Organism |
---|---|
purified recombinant GRK2 in complex with purified recombinant G protein beta1gamma2 subunits, X-ray diffraction structure determination and analysis at 2.5 A resolution, modeling | Bos taurus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | associated, GRK2 in complex with G protein beta1gamma2 subunits | Bos taurus | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Bos taurus | phosphorylation of heptahelical receptors by GRK2 is a universal regulatory mehanism leading to desensitization of G protein signaling and to the activation of alternative signaling pathways | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP + [beta-adrenergic receptor] = ADP + phospho-[beta-adrenergic receptor] | substrate and activator binding site structure, active site structure, structure-function relationship, overview | Bos taurus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | phosphorylation of heptahelical receptors by GRK2 is a universal regulatory mehanism leading to desensitization of G protein signaling and to the activation of alternative signaling pathways | Bos taurus | ? | - |
? | |
additional information | the enzyme contains regulatory sites for Ca2+/calmodulin, protein kinase C, and clathrin | Bos taurus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | GRK2 consists of 3 modular domains: a predominantly N-terminal RGS homology domain, a central protein kinase domain, and a C-terminal pleckstrin homology domain, domain functions, overview | Bos taurus |
Synonyms | Comment | Organism |
---|---|---|
G protein-coupled receptor kinase 2 | - |
Bos taurus |
GRK2 | - |
Bos taurus |
guanine nucleotide-binding protein-coupled receptor kinase | - |
Bos taurus |