reaction mechanism of C-H bond cleavage, overview. MAO oxidation of benzylamines and phenethylamines exhibit large deuterium kinetic isotope effects showing, in most instances, that C-H bond cleavage is rate limiting in catalysis
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amine:oxygen oxidoreductase (deaminating)
A mitochondrial outer-membrane flavoprotein (FAD) that catalyses the oxidative deamination of neurotransmitters and biogenic amines . Acts on primary amines, and also on some secondary and tertiary amines. It differs from EC 18.104.22.168, primary-amine oxidase as it can oxidize secondary and tertiary amines but not methylamine. This enzyme is inhibited by acetylenic compounds such as chlorgyline, 1-deprenyl and pargyline but, unlike EC 22.214.171.124 and EC 126.96.36.199 (diamine oxidase), it is not inhibited by semicarbazide.