Information on EC 1.4.3.4 - monoamine oxidase

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The expected taxonomic range for this enzyme is: Eukaryota

EC NUMBER
COMMENTARY
1.4.3.4
-
RECOMMENDED NAME
GeneOntology No.
monoamine oxidase
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
Deamination
-
-
-
-
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
Arginine and proline metabolism
-
aromatic biogenic amine degradation (bacteria)
-
Biosynthesis of secondary metabolites
-
dopamine degradation
-
Drug metabolism - cytochrome P450
-
Glycine, serine and threonine metabolism
-
Histidine metabolism
-
Isoquinoline alkaloid biosynthesis
-
melatonin degradation II
-
Metabolic pathways
-
noradrenaline and adrenaline degradation
-
phenylalanine degradation IV (mammalian, via side chain)
-
Phenylalanine metabolism
-
putrescine degradation III
-
salidroside biosynthesis
-
serotonin degradation
-
tryptophan degradation VI (via tryptamine)
-
tryptophan degradation X (mammalian, via tryptamine)
-
Tryptophan metabolism
-
Tyrosine metabolism
-
SYSTEMATIC NAME
IUBMB Comments
amine:oxygen oxidoreductase (deaminating)
A mitochondrial outer-membrane flavoprotein (FAD) that catalyses the oxidative deamination of neurotransmitters and biogenic amines [3]. Acts on primary amines, and also on some secondary and tertiary amines. It differs from EC 1.4.3.21, primary-amine oxidase as it can oxidize secondary and tertiary amines but not methylamine. This enzyme is inhibited by acetylenic compounds such as chlorgyline, 1-deprenyl and pargyline but, unlike EC 1.4.3.21 and EC 1.4.3.22 (diamine oxidase), it is not inhibited by semicarbazide.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
adrenaline oxidase
-
-
-
-
amine-oxygen oxidoreductase
-
-
epinephrine oxidase
-
-
-
-
MAO
-
-
-
-
MAO
Coregonus lavaretus ludoga
-
-
MAO
Q6NSN2
-
MAO
Danio rerio Turku
-
-
-
MAO
P27338
-
MAO A
-
-
MAO A
P21398
-
MAO A
-
-
MAO A
Q64133
-
MAO A
-
isoform
MAO B
-
-
MAO B
P56560
-
MAO B
-
isoform
MAO B
-
-
MAO B
Q8BW75
-
MAO B
-
-
MAO type B
P27338
-
MAO-A
Q64133
-
MAO-A
P21397
-
MAO-A
-
-
MAO-A
-
-
MAO-A
-
isoform
MAO-A
P21397
-
MAO-A
P21936
-
MAO-A
Q6Q2J0
-
MAO-B
-
-
MAO-B
-
-
MAO-B
-
-
MAO-B
-
isoform
MAO-B
P21396
-
MAO-B
Q5UL99
-
MAO-B
Rattus norvegicus Wistar
P19643
-
-
MAO-N
P46882
-
MAOA
-
-
MAOA
Rattus norvegicus MAO-A
-
-
-
MAOB
P21397
-
MAOB
P19643
-
monoamine oxidase
-
-
-
-
monoamine oxidase
-
-
monoamine oxidase
P21397, P27338
-
monoamine oxidase
-
-
monoamine oxidase
Q64133
-
monoamine oxidase
-
-
monoamine oxidase A
-
-
monoamine oxidase A
P21398
-
monoamine oxidase A
-
-
monoamine oxidase A
-
-
monoamine oxidase A
-
-
monoamine oxidase A
-
-
monoamine oxidase A
Q64133
-
monoamine oxidase A
-
-
monoamine oxidase A
P21397
-
monoamine oxidase A
-
-
monoamine oxidase A
-
-
monoamine oxidase A
-
isoform
monoamine oxidase B
-
-
monoamine oxidase B
P56560
-
monoamine oxidase B
-
-
monoamine oxidase B
-
-
monoamine oxidase B
-
-
monoamine oxidase B
P21397
-
monoamine oxidase B
-
-
monoamine oxidase B
-
-
monoamine oxidase B
Q8BW75
-
monoamine oxidase B
-
-
monoamine oxidase B
-
-
monoamine oxidase B
-
-
monoamine oxidase B
-
-
monoamine oxidase B
-
-
monoamine oxidase B
-
-
monoamine oxidase B
-
isoform
monoamine oxidase B
P21396
-
monoamine oxidase type B
P27338
-
monoamine oxidase-A
-
-
monoamine oxidase-A
P21397
-
monoamine oxidase-A
-
-
monoamine oxidase-A
P21396
-
monoamine oxidase-B
-
-
monoamine oxidase-B
P27338
-
monoamine oxidase-B
-
-
monoamine oxidaseA
P21397
-
monoamine oxidases A
-
-
monoamine oxidases B
-
-
monoamine-oxidase-A
P21397
-
monoamine:O2 oxidoreductase (deaminating)
-
-
-
-
monoamine:O2 oxidoreductase, deaminating
-
-
monoamine:O2-oxidoreductase deaminating
Coregonus lavaretus ludoga
-
-
semicarbazide-sensitive amine oxidase
-
-
serotonin deaminase
-
-
-
-
tyraminase
-
-
-
-
tyramine oxidase
-
-
-
-
zMAO
-
-
monoaminoxidase B
P27338
-
additional information
-
isoforms differ in inhibitor sensitivity
additional information
-
isoforms differ in inhibitor sensitivity; MAO-A and MAO-B are 2 different isoenzymic forms which differ in substrate specificity, distribution among tissues and their structures
additional information
-
MAO is a novel type of disulfide oxidoreductase
additional information
-
the N-terminal region of the two isoenzymes is not involved in the different specificity of the two isoenzymes for substrates and inhibitors
additional information
-
isoforms differ in inhibitor sensitivity; MAO-A and MAO-B are 2 different isoenzymic forms which differ in substrate specificity, distribution among tissues and their structures
additional information
-
MAO-A and MAO-B are 2 different isoenzymic forms which differ in substrate specificity, distribution among tissues and their structures
additional information
-
isoforms differ in inhibitor sensitivity; MAO-A and MAO-B are 2 different isoenzymic forms which differ in substrate specificity, distribution among tissues and their structures
CAS REGISTRY NUMBER
COMMENTARY
9001-66-5
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
two amine oxidases isolated: the first one corresponds to the copper-dependent enzyme, the second one is an evolutionary prototype form of MAO-A and B
-
-
Manually annotated by BRENDA team
cultivar Miechikara
-
-
Manually annotated by BRENDA team
MAO A and MAO B are encoded by separate genes
-
-
Manually annotated by BRENDA team
Coregonus lavaretus ludoga
-
-
-
Manually annotated by BRENDA team
of Turku strain
-
-
Manually annotated by BRENDA team
Danio rerio Turku
of Turku strain
-
-
Manually annotated by BRENDA team
white leghorn
-
-
Manually annotated by BRENDA team
expressed in Pichia pastoris strain KM71
SwissProt
Manually annotated by BRENDA team
expressed in Saccharomyces cerevisiae
SwissProt
Manually annotated by BRENDA team
isozyme MAO A
-
-
Manually annotated by BRENDA team
isozyme MAO-B
-
-
Manually annotated by BRENDA team
Korean individuals
-
-
Manually annotated by BRENDA team
male children
-
-
Manually annotated by BRENDA team
MAO-A and MAO-B are encoded by separate genes
-
-
Manually annotated by BRENDA team
MAO-B; isozyme MAO B
SwissProt
Manually annotated by BRENDA team
MAOA
SwissProt
Manually annotated by BRENDA team
MAOB
SwissProt
Manually annotated by BRENDA team
recombinant
SwissProt
Manually annotated by BRENDA team
recombinant
SwissProt
Manually annotated by BRENDA team
transgenic C57Bl6 mice inducibly expressing human MAO-B selectively within astrocytes
SwissProt
Manually annotated by BRENDA team
European lamprey
-
-
Manually annotated by BRENDA team
female scrapie-infected hamsters
-
-
Manually annotated by BRENDA team
MAO A and MAO B are encoded by separate genes
-
-
Manually annotated by BRENDA team
Tg8 is a transgenic mouse strain lacking a functional MAO A gene
SwissProt
Manually annotated by BRENDA team
wild-type FVB/N and Tg-CYP2D6 mice
-
-
Manually annotated by BRENDA team
American mink, several isozymes
-
-
Manually annotated by BRENDA team
baboon
-
-
Manually annotated by BRENDA team
; nine-week-old male Wistar rats
SwissProt
Manually annotated by BRENDA team
expressed in Pichia pastoris strain KM71
SwissProt
Manually annotated by BRENDA team
male Sprague-Dawley
SwissProt
Manually annotated by BRENDA team
male Wistar rats
SwissProt
Manually annotated by BRENDA team
MAO A and MAO B are encoded by separate genes
-
-
Manually annotated by BRENDA team
MAO-A; male albino rats, isozyme MAO-A
SwissProt
Manually annotated by BRENDA team
MAO-B; male albino rats, isozyme MAO-B
SwissProt
Manually annotated by BRENDA team
pregnant Sprague-Dawley
-
-
Manually annotated by BRENDA team
Sprague Dawley
SwissProt
Manually annotated by BRENDA team
Wistar
SwissProt
Manually annotated by BRENDA team
Wistar rats, several isozymes
-
-
Manually annotated by BRENDA team
Rattus norvegicus MAO-A
MAO-A
-
-
Manually annotated by BRENDA team
Rattus norvegicus Wistar
Wistar
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
TEMPERATURE RANGE
TEMPERATURE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
additional information
-
-
temperature-dependencies of enzyme activity of purified and lipid-treated enzyme
PDB
SCOP
CATH
ORGANISM
Rhizobium meliloti (strain 1021)